A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum

A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum

ABSTRACT Caseous necrosis is a hallmark of tuberculosis (TB) pathology and creates a niche for drug-tolerant persisters within the host. Cavitary TB and high bacterial burden in caseum require longer treatment duration. An in vitro model that recapitulates the major features of Mycobacterium tubercu...

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Bibliographic Details
Main Authors: Jansy P. Sarathy, Min Xie, Richard M. Jones, Adrienne Chang, Paulina Osiecki, Danielle Weiner, Wen-Shan Tsao, Maureen Dougher, Landry Blanc, Nader Fotouhi, Laura E. Via, Clifton E. Barry, Iwijn De Vlaminck, David R. Sherman, Véronique A. Dartois
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
caseum
nonreplicating Mycobacterium tuberculosis
persister
tuberculosis
vulnerable target
Online Access:https://journals.asm.org/doi/10.1128/mbio.00598-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00598-23

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