Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity

Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity

In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of mutagens, driving viral populations to extinction. Extinction catastrophe can be experimentally induced by promutagenic...

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Bibliographic Details
Main Authors: Ikbel Hadj Hassine, Manel Ben M’hadheb, Luis Menéndez-Arias
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
lethal mutagenesis
error catastrophe
nucleoside analogs
ribavirin
favipiravir
molnupiravir
Online Access:https://www.mdpi.com/1999-4915/14/4/841

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