Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug
<p>Abstract</p> <p>The P123/ACP nanocomposite with sizes less than 100 nm consisting of triblock copolymer P123 and amorphous calcium phosphate (ACP) has been prepared by using an aqueous solution containing CaCl<sub>2</sub>, (NH<sub>4</sub>)<sub>3<...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2010-01-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1007/s11671-010-9558-5 |
| _version_ | 1797762444879200256 |
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| author | Cao Shao-Wen Zhu Ying-Jie Wu Jin Wang Ke-Wei Tang Qi-Li |
| author_facet | Cao Shao-Wen Zhu Ying-Jie Wu Jin Wang Ke-Wei Tang Qi-Li |
| author_sort | Cao Shao-Wen |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The P123/ACP nanocomposite with sizes less than 100 nm consisting of triblock copolymer P123 and amorphous calcium phosphate (ACP) has been prepared by using an aqueous solution containing CaCl<sub>2</sub>, (NH<sub>4</sub>)<sub>3</sub>PO<sub>4</sub>, and P123 at room temperature. The P123/ACP nanocomposite is used as the nanocarrier for hydrophobic drug ibuprofen, based on the combined advantages of both amphiphilic block copolymer and calcium phosphate delivery system. The P123/ACP nanocomposite has a much higher ibuprofen loading capacity (148 mg/g) than the single-phase calcium phosphate nanostructures. The drug release percentage of the P123/ACP nanocomposite in simulated body fluid reaches about 100% in a period of 156 h, which is much slower than that of single-phase calcium phosphate nanostructures. It is expected that the P123/ACP nanocomposite is promising for the application in the controlled delivery of hydrophobic drugs.</p> |
| first_indexed | 2024-03-12T19:27:27Z |
| format | Article |
| id | doaj.art-336384860ee9455faefaa4e2884d0644 |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T19:27:27Z |
| publishDate | 2010-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-336384860ee9455faefaa4e2884d06442023-08-02T04:47:10ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2010-01-0154781785Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic DrugCao Shao-WenZhu Ying-JieWu JinWang Ke-WeiTang Qi-Li<p>Abstract</p> <p>The P123/ACP nanocomposite with sizes less than 100 nm consisting of triblock copolymer P123 and amorphous calcium phosphate (ACP) has been prepared by using an aqueous solution containing CaCl<sub>2</sub>, (NH<sub>4</sub>)<sub>3</sub>PO<sub>4</sub>, and P123 at room temperature. The P123/ACP nanocomposite is used as the nanocarrier for hydrophobic drug ibuprofen, based on the combined advantages of both amphiphilic block copolymer and calcium phosphate delivery system. The P123/ACP nanocomposite has a much higher ibuprofen loading capacity (148 mg/g) than the single-phase calcium phosphate nanostructures. The drug release percentage of the P123/ACP nanocomposite in simulated body fluid reaches about 100% in a period of 156 h, which is much slower than that of single-phase calcium phosphate nanostructures. It is expected that the P123/ACP nanocomposite is promising for the application in the controlled delivery of hydrophobic drugs.</p>http://dx.doi.org/10.1007/s11671-010-9558-5NanocompositeP123Calcium phosphateHydrophobic drugSustained release |
| spellingShingle | Cao Shao-Wen Zhu Ying-Jie Wu Jin Wang Ke-Wei Tang Qi-Li Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug Nanoscale Research Letters Nanocomposite P123 Calcium phosphate Hydrophobic drug Sustained release |
| title | Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug |
| title_full | Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug |
| title_fullStr | Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug |
| title_full_unstemmed | Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug |
| title_short | Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug |
| title_sort | preparation and sustained release property of triblock copolymer calcium phosphate nanocomposite as nanocarrier for hydrophobic drug |
| topic | Nanocomposite P123 Calcium phosphate Hydrophobic drug Sustained release |
| url | http://dx.doi.org/10.1007/s11671-010-9558-5 |
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