Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer
The study of chemicals extracted from natural sources should be encouraged due to the significant number of cancer deaths each year and the financial burden imposed by this disease on society. The causes of almost all cancers involve a combination of lifestyle, environmental factors, and genetic and...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-05-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224003810 |
| _version_ | 1797235592303476736 |
|---|---|
| author | Kazi Rejvee Ahmed Md. Masudur Rahman Md. Nahidul Islam Md. Maharub Hossain Fahim Md Ataur Rahman Bonglee Kim |
| author_facet | Kazi Rejvee Ahmed Md. Masudur Rahman Md. Nahidul Islam Md. Maharub Hossain Fahim Md Ataur Rahman Bonglee Kim |
| author_sort | Kazi Rejvee Ahmed |
| collection | DOAJ |
| description | The study of chemicals extracted from natural sources should be encouraged due to the significant number of cancer deaths each year and the financial burden imposed by this disease on society. The causes of almost all cancers involve a combination of lifestyle, environmental factors, and genetic and inherited factors. Modern medicine researchers are increasingly interested in traditional phytochemicals as they hold potential for new bioactive compounds with medical applications. Recent publications have provided evidence of the antitumor properties of phytochemicals, a key component of traditional Chinese medicine, thereby opening new avenues for their use in modern medicine. Various studies have demonstrated a strong correlation between apoptosis and autophagy, two critical mechanisms involved in cancer formation and regulation, indicating diverse forms of crosstalk between them. Phytochemicals have the ability to activate both pro-apoptotic and pro-autophagic pathways. Therefore, understanding how phytochemicals influence the relationship between apoptosis and autophagy is crucial for developing a new cancer treatment strategy that targets these molecular mechanisms. This review aims to explore natural phytochemicals that have demonstrated anticancer effects, focusing on their role in regulating the crosstalk between apoptosis and autophagy, which contributes to uncontrolled tumor cell growth. Additionally, the review highlights the limitations and challenges of current research methodologies while suggesting potential avenues for future research in this field. |
| first_indexed | 2024-04-24T16:50:24Z |
| format | Article |
| id | doaj.art-3363b54a9c7f4a04a22d365b6b609586 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-24T16:50:24Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-3363b54a9c7f4a04a22d365b6b6095862024-03-29T05:49:34ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-05-01174116497Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancerKazi Rejvee Ahmed0Md. Masudur Rahman1Md. Nahidul Islam2Md. Maharub Hossain Fahim3Md Ataur Rahman4Bonglee Kim5Department of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, South Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, South KoreaDepartment of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, BangladeshDepartment of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, BangladeshDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, South KoreaDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, United StatesDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, South Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, South Korea; Corresponding author at: Department of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, South Korea.The study of chemicals extracted from natural sources should be encouraged due to the significant number of cancer deaths each year and the financial burden imposed by this disease on society. The causes of almost all cancers involve a combination of lifestyle, environmental factors, and genetic and inherited factors. Modern medicine researchers are increasingly interested in traditional phytochemicals as they hold potential for new bioactive compounds with medical applications. Recent publications have provided evidence of the antitumor properties of phytochemicals, a key component of traditional Chinese medicine, thereby opening new avenues for their use in modern medicine. Various studies have demonstrated a strong correlation between apoptosis and autophagy, two critical mechanisms involved in cancer formation and regulation, indicating diverse forms of crosstalk between them. Phytochemicals have the ability to activate both pro-apoptotic and pro-autophagic pathways. Therefore, understanding how phytochemicals influence the relationship between apoptosis and autophagy is crucial for developing a new cancer treatment strategy that targets these molecular mechanisms. This review aims to explore natural phytochemicals that have demonstrated anticancer effects, focusing on their role in regulating the crosstalk between apoptosis and autophagy, which contributes to uncontrolled tumor cell growth. Additionally, the review highlights the limitations and challenges of current research methodologies while suggesting potential avenues for future research in this field.http://www.sciencedirect.com/science/article/pii/S0753332224003810AntioxidantsPhytochemicalsAutophagyApoptosisCancer |
| spellingShingle | Kazi Rejvee Ahmed Md. Masudur Rahman Md. Nahidul Islam Md. Maharub Hossain Fahim Md Ataur Rahman Bonglee Kim Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer Biomedicine & Pharmacotherapy Antioxidants Phytochemicals Autophagy Apoptosis Cancer |
| title | Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer |
| title_full | Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer |
| title_fullStr | Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer |
| title_full_unstemmed | Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer |
| title_short | Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer |
| title_sort | antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer |
| topic | Antioxidants Phytochemicals Autophagy Apoptosis Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224003810 |
| work_keys_str_mv | AT kazirejveeahmed antioxidantsactivitiesofphytochemicalsperspectivemodulationofautophagyandapoptosistotreatingcancer AT mdmasudurrahman antioxidantsactivitiesofphytochemicalsperspectivemodulationofautophagyandapoptosistotreatingcancer AT mdnahidulislam antioxidantsactivitiesofphytochemicalsperspectivemodulationofautophagyandapoptosistotreatingcancer AT mdmaharubhossainfahim antioxidantsactivitiesofphytochemicalsperspectivemodulationofautophagyandapoptosistotreatingcancer AT mdataurrahman antioxidantsactivitiesofphytochemicalsperspectivemodulationofautophagyandapoptosistotreatingcancer AT bongleekim antioxidantsactivitiesofphytochemicalsperspectivemodulationofautophagyandapoptosistotreatingcancer |