A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides?
Background: This was a meta-analysis and systematic review to determine the global prevalence of the mitochondrially encoded 12S RNA (MT-RNR1) genetic mutation in order to assess the need for neonatal screening prior to aminoglycoside therapy. Materials and Methods: A comprehensive search of MEDLINE...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | African Journal of Paediatric Surgery |
| Subjects: | |
| Online Access: | http://www.afrjpaedsurg.org/article.asp?issn=0189-6725;year=2015;volume=12;issue=2;spage=105;epage=113;aulast=Ibekwe |
| _version_ | 1818403056653434880 |
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| author | Titus S Ibekwe Sanjiv K Bhimrao Brian D Westerberg Frederick K Kozak |
| author_facet | Titus S Ibekwe Sanjiv K Bhimrao Brian D Westerberg Frederick K Kozak |
| author_sort | Titus S Ibekwe |
| collection | DOAJ |
| description | Background: This was a meta-analysis and systematic review to determine the global prevalence of the mitochondrially encoded 12S RNA (MT-RNR1) genetic mutation in order to assess the need for neonatal screening prior to aminoglycoside therapy. Materials and Methods: A comprehensive search of MEDLINE, EMBASE, Ovid, Database of Abstracts of Reviews of Effect, Cochrane Library, Clinical Evidence and Cochrane Central Register of Trials was performed including cross-referencing independently by 2 assessors. Selections were restricted to human studies in English. Meta-analysis was done with MetaXL 2013. Results: Forty-five papers out of 295 met the criteria. Pooled prevalence in the general population for MT-RNR1 gene mutations (A1555G, C1494T, A7445G) was 2% (1-4%) at 99%. Conclusion: Routine screening for MT-RNR1 mutations in the general population prior to treatment with aminoglycosides appear desirable but poorly supported by the weak level of evidence available in the literature. Routine screening in high-risk (Chinese and Spanish) populations appear justified. |
| first_indexed | 2024-12-14T08:18:11Z |
| format | Article |
| id | doaj.art-33648eee8a024081b56335ad096e58fd |
| institution | Directory Open Access Journal |
| issn | 0189-6725 0974-5998 |
| language | English |
| last_indexed | 2024-12-14T08:18:11Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | African Journal of Paediatric Surgery |
| spelling | doaj.art-33648eee8a024081b56335ad096e58fd2022-12-21T23:09:52ZengWolters Kluwer Medknow PublicationsAfrican Journal of Paediatric Surgery0189-67250974-59982015-01-0112210511310.4103/0189-6725.160342A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides?Titus S IbekweSanjiv K BhimraoBrian D WesterbergFrederick K KozakBackground: This was a meta-analysis and systematic review to determine the global prevalence of the mitochondrially encoded 12S RNA (MT-RNR1) genetic mutation in order to assess the need for neonatal screening prior to aminoglycoside therapy. Materials and Methods: A comprehensive search of MEDLINE, EMBASE, Ovid, Database of Abstracts of Reviews of Effect, Cochrane Library, Clinical Evidence and Cochrane Central Register of Trials was performed including cross-referencing independently by 2 assessors. Selections were restricted to human studies in English. Meta-analysis was done with MetaXL 2013. Results: Forty-five papers out of 295 met the criteria. Pooled prevalence in the general population for MT-RNR1 gene mutations (A1555G, C1494T, A7445G) was 2% (1-4%) at 99%. Conclusion: Routine screening for MT-RNR1 mutations in the general population prior to treatment with aminoglycosides appear desirable but poorly supported by the weak level of evidence available in the literature. Routine screening in high-risk (Chinese and Spanish) populations appear justified.http://www.afrjpaedsurg.org/article.asp?issn=0189-6725;year=2015;volume=12;issue=2;spage=105;epage=113;aulast=IbekweAminoglycosidemitochondrial geneticsmutationribosomal ribonucleic acidsensorineural hearing loss |
| spellingShingle | Titus S Ibekwe Sanjiv K Bhimrao Brian D Westerberg Frederick K Kozak A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides? African Journal of Paediatric Surgery Aminoglycoside mitochondrial genetics mutation ribosomal ribonucleic acid sensorineural hearing loss |
| title | A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides? |
| title_full | A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides? |
| title_fullStr | A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides? |
| title_full_unstemmed | A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides? |
| title_short | A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides? |
| title_sort | meta analysis and systematic review of the prevalence of mitochondrially encoded 12s rna in the general population is there a role for screening neonates requiring aminoglycosides |
| topic | Aminoglycoside mitochondrial genetics mutation ribosomal ribonucleic acid sensorineural hearing loss |
| url | http://www.afrjpaedsurg.org/article.asp?issn=0189-6725;year=2015;volume=12;issue=2;spage=105;epage=113;aulast=Ibekwe |
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