A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides?

A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides?

Background: This was a meta-analysis and systematic review to determine the global prevalence of the mitochondrially encoded 12S RNA (MT-RNR1) genetic mutation in order to assess the need for neonatal screening prior to aminoglycoside therapy. Materials and Methods: A comprehensive search of MEDLINE...

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Bibliographic Details
Main Authors: Titus S Ibekwe, Sanjiv K Bhimrao, Brian D Westerberg, Frederick K Kozak
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:African Journal of Paediatric Surgery
Subjects:
Aminoglycoside
mitochondrial genetics
mutation
ribosomal ribonucleic acid
sensorineural hearing loss
Online Access:http://www.afrjpaedsurg.org/article.asp?issn=0189-6725;year=2015;volume=12;issue=2;spage=105;epage=113;aulast=Ibekwe

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