The roads to ferroptosis under homeostatic versus pathological conditions
The calcium-independent phospholipase iPLA2β has been identified as a transcriptional target of the tumor suppressor TP53 (or p53). Unlike GPX4 (glutathione peroxidase 4), iPLA2β is not required for normal homeostasis but critical for ferroptosis during stress responses. Our results implicate iPLA2β...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-09-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.1970477 |
| _version_ | 1827809325997883392 |
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| author | Vincent Chen Chu Bo Wei Gu |
| author_facet | Vincent Chen Chu Bo Wei Gu |
| author_sort | Vincent Chen |
| collection | DOAJ |
| description | The calcium-independent phospholipase iPLA2β has been identified as a transcriptional target of the tumor suppressor TP53 (or p53). Unlike GPX4 (glutathione peroxidase 4), iPLA2β is not required for normal homeostasis but critical for ferroptosis during stress responses. Our results implicate iPLA2β as an essential regulator in a noncanonical ferroptosis pathway. |
| first_indexed | 2024-03-11T22:39:37Z |
| format | Article |
| id | doaj.art-3365c6faa33842e282e2c46de0cec989 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:37Z |
| publishDate | 2021-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-3365c6faa33842e282e2c46de0cec9892023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-09-018510.1080/23723556.2021.19704771970477The roads to ferroptosis under homeostatic versus pathological conditionsVincent Chen0Chu Bo1Wei Gu2Columbia UniversityColumbia UniversityColumbia UniversityThe calcium-independent phospholipase iPLA2β has been identified as a transcriptional target of the tumor suppressor TP53 (or p53). Unlike GPX4 (glutathione peroxidase 4), iPLA2β is not required for normal homeostasis but critical for ferroptosis during stress responses. Our results implicate iPLA2β as an essential regulator in a noncanonical ferroptosis pathway.http://dx.doi.org/10.1080/23723556.2021.1970477ferroptosisipla2βp53lipid peroxidation |
| spellingShingle | Vincent Chen Chu Bo Wei Gu The roads to ferroptosis under homeostatic versus pathological conditions Molecular & Cellular Oncology ferroptosis ipla2β p53 lipid peroxidation |
| title | The roads to ferroptosis under homeostatic versus pathological conditions |
| title_full | The roads to ferroptosis under homeostatic versus pathological conditions |
| title_fullStr | The roads to ferroptosis under homeostatic versus pathological conditions |
| title_full_unstemmed | The roads to ferroptosis under homeostatic versus pathological conditions |
| title_short | The roads to ferroptosis under homeostatic versus pathological conditions |
| title_sort | roads to ferroptosis under homeostatic versus pathological conditions |
| topic | ferroptosis ipla2β p53 lipid peroxidation |
| url | http://dx.doi.org/10.1080/23723556.2021.1970477 |
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