Vitamin D on early stages of diabetic kidney disease: A cross-sectional study in patients with type 1 diabetes mellitus.
Context: Genetic and environmental factors are involved in the pathogenesis of type 1 diabetes mellitus (T1DM), and vitamin D deficiency appears as a candidate to risk factor for developing diabetic kidney disease (DKD). Objective: The purpose of study was to evaluate the existence of an association...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-12-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00149/full |
| _version_ | 1818007118605713408 |
|---|---|
| author | João Soares Felício Rafael Luz Franciane de Melo Fabrício Resende Alana de Oliveira Amanda Soares Peixoto João Felício Neto Carolina Tavares Carvalho Denisson da Silva Márcia dos Santos Natércia de Queiroz Manuela de Lemos Elizabeth Yamada Karem Felício |
| author_facet | João Soares Felício Rafael Luz Franciane de Melo Fabrício Resende Alana de Oliveira Amanda Soares Peixoto João Felício Neto Carolina Tavares Carvalho Denisson da Silva Márcia dos Santos Natércia de Queiroz Manuela de Lemos Elizabeth Yamada Karem Felício |
| author_sort | João Soares Felício |
| collection | DOAJ |
| description | Context: Genetic and environmental factors are involved in the pathogenesis of type 1 diabetes mellitus (T1DM), and vitamin D deficiency appears as a candidate to risk factor for developing diabetic kidney disease (DKD). Objective: The purpose of study was to evaluate the existence of an association between low levels of vitamin D and the presence and degree of DKD in T1DM. Patients and methods: We performed a cross-sectional study, between November 2014 and December 2015. Levels of 25(OH)D and albuminuria were analyzed in 37 patients with T1DM and normal glomerular filtration rate. Thirty- six subjects were evaluated as a control group. Results: Patients with T1DM and hypovitaminosis D had higher levels of albuminuria compared to those with normal vitamin D levels (albuminuria (log10) = 1.92 vs 1.44; p <0.05). When we have separated the group of patients according to stage of DKD in patients with normo, micro and macroalbuminuria, there are lower levels of 25(OH)D in the last when compared to the first two groups (26.7 ± 6.2, 24.8 ± 7,0 and 15.9 ± 7.6 ng/ml; p <0.05, respectively). In T1DM group, we have found correlations between vitamin D levels and both albuminuria and DKD stages (r= -0.5, p <0.01 and r= -0.4; p <0.05, respectively). A simple linear regression model, with albuminuria as the dependent variable and vitamin D as an independent variable, showed r2= 0.2 and p <0.01. Conclusions: Our data suggest an association between reduced levels of vitamin D and the presence and severity of DKD. |
| first_indexed | 2024-04-14T05:10:42Z |
| format | Article |
| id | doaj.art-3366a455790d4194b22abb0f4f868e5e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-14T05:10:42Z |
| publishDate | 2016-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3366a455790d4194b22abb0f4f868e5e2022-12-22T02:10:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922016-12-01710.3389/fendo.2016.00149232852Vitamin D on early stages of diabetic kidney disease: A cross-sectional study in patients with type 1 diabetes mellitus.João Soares Felício0Rafael Luz1Franciane de Melo2Fabrício Resende3Alana de Oliveira4Amanda Soares Peixoto5João Felício Neto6Carolina Tavares Carvalho7Denisson da Silva8Márcia dos Santos9Natércia de Queiroz10Manuela de Lemos11Elizabeth Yamada12Karem Felício13University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology DivisionContext: Genetic and environmental factors are involved in the pathogenesis of type 1 diabetes mellitus (T1DM), and vitamin D deficiency appears as a candidate to risk factor for developing diabetic kidney disease (DKD). Objective: The purpose of study was to evaluate the existence of an association between low levels of vitamin D and the presence and degree of DKD in T1DM. Patients and methods: We performed a cross-sectional study, between November 2014 and December 2015. Levels of 25(OH)D and albuminuria were analyzed in 37 patients with T1DM and normal glomerular filtration rate. Thirty- six subjects were evaluated as a control group. Results: Patients with T1DM and hypovitaminosis D had higher levels of albuminuria compared to those with normal vitamin D levels (albuminuria (log10) = 1.92 vs 1.44; p <0.05). When we have separated the group of patients according to stage of DKD in patients with normo, micro and macroalbuminuria, there are lower levels of 25(OH)D in the last when compared to the first two groups (26.7 ± 6.2, 24.8 ± 7,0 and 15.9 ± 7.6 ng/ml; p <0.05, respectively). In T1DM group, we have found correlations between vitamin D levels and both albuminuria and DKD stages (r= -0.5, p <0.01 and r= -0.4; p <0.05, respectively). A simple linear regression model, with albuminuria as the dependent variable and vitamin D as an independent variable, showed r2= 0.2 and p <0.01. Conclusions: Our data suggest an association between reduced levels of vitamin D and the presence and severity of DKD.http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00149/fullAlbuminuriaVitamin Dtype 1 diabetes mellitus25(OH)DDiabetic kidney disease |
| spellingShingle | João Soares Felício Rafael Luz Franciane de Melo Fabrício Resende Alana de Oliveira Amanda Soares Peixoto João Felício Neto Carolina Tavares Carvalho Denisson da Silva Márcia dos Santos Natércia de Queiroz Manuela de Lemos Elizabeth Yamada Karem Felício Vitamin D on early stages of diabetic kidney disease: A cross-sectional study in patients with type 1 diabetes mellitus. Frontiers in Endocrinology Albuminuria Vitamin D type 1 diabetes mellitus 25(OH)D Diabetic kidney disease |
| title | Vitamin D on early stages of diabetic kidney disease: A cross-sectional study in patients with type 1 diabetes mellitus. |
| title_full | Vitamin D on early stages of diabetic kidney disease: A cross-sectional study in patients with type 1 diabetes mellitus. |
| title_fullStr | Vitamin D on early stages of diabetic kidney disease: A cross-sectional study in patients with type 1 diabetes mellitus. |
| title_full_unstemmed | Vitamin D on early stages of diabetic kidney disease: A cross-sectional study in patients with type 1 diabetes mellitus. |
| title_short | Vitamin D on early stages of diabetic kidney disease: A cross-sectional study in patients with type 1 diabetes mellitus. |
| title_sort | vitamin d on early stages of diabetic kidney disease a cross sectional study in patients with type 1 diabetes mellitus |
| topic | Albuminuria Vitamin D type 1 diabetes mellitus 25(OH)D Diabetic kidney disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00149/full |
| work_keys_str_mv | AT joaosoaresfelicio vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT rafaelluz vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT francianedemelo vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT fabricioresende vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT alanadeoliveira vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT amandasoarespeixoto vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT joaofelicioneto vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT carolinatavarescarvalho vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT denissondasilva vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT marciadossantos vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT naterciadequeiroz vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT manueladelemos vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT elizabethyamada vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus AT karemfelicio vitamindonearlystagesofdiabetickidneydiseaseacrosssectionalstudyinpatientswithtype1diabetesmellitus |