Neurogenesis as a Tool for Spinal Cord Injury
Spinal cord injury is a devastating medical condition with no effective treatment. One approach to SCI treatment may be provided by stem cells (SCs). Studies have mainly focused on the transplantation of exogenous SCs, but the induction of endogenous SCs has also been considered as an alternative. W...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/7/3728 |
| _version_ | 1797438986178789376 |
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| author | Katerina Havelikova Barbora Smejkalova Pavla Jendelova |
| author_facet | Katerina Havelikova Barbora Smejkalova Pavla Jendelova |
| author_sort | Katerina Havelikova |
| collection | DOAJ |
| description | Spinal cord injury is a devastating medical condition with no effective treatment. One approach to SCI treatment may be provided by stem cells (SCs). Studies have mainly focused on the transplantation of exogenous SCs, but the induction of endogenous SCs has also been considered as an alternative. While the differentiation potential of neural stem cells in the brain neurogenic regions has been known for decades, there are ongoing debates regarding the multipotent differentiation potential of the ependymal cells of the central canal in the spinal cord (SCECs). Following spinal cord insult, SCECs start to proliferate and differentiate mostly into astrocytes and partly into oligodendrocytes, but not into neurons. However, there are several approaches concerning how to increase neurogenesis in the injured spinal cord, which are discussed in this review. The potential treatment approaches include drug administration, the reduction of neuroinflammation, neuromodulation with physical factors and in vivo reprogramming. |
| first_indexed | 2024-03-09T11:46:19Z |
| format | Article |
| id | doaj.art-3366c22f07354308982c50785065fc8f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:46:19Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3366c22f07354308982c50785065fc8f2023-11-30T23:21:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237372810.3390/ijms23073728Neurogenesis as a Tool for Spinal Cord InjuryKaterina Havelikova0Barbora Smejkalova1Pavla Jendelova2Institute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech RepublicInstitute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech RepublicInstitute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech RepublicSpinal cord injury is a devastating medical condition with no effective treatment. One approach to SCI treatment may be provided by stem cells (SCs). Studies have mainly focused on the transplantation of exogenous SCs, but the induction of endogenous SCs has also been considered as an alternative. While the differentiation potential of neural stem cells in the brain neurogenic regions has been known for decades, there are ongoing debates regarding the multipotent differentiation potential of the ependymal cells of the central canal in the spinal cord (SCECs). Following spinal cord insult, SCECs start to proliferate and differentiate mostly into astrocytes and partly into oligodendrocytes, but not into neurons. However, there are several approaches concerning how to increase neurogenesis in the injured spinal cord, which are discussed in this review. The potential treatment approaches include drug administration, the reduction of neuroinflammation, neuromodulation with physical factors and in vivo reprogramming.https://www.mdpi.com/1422-0067/23/7/3728neurogenesisspinal cord injuryependymal stem cellsastrocytesreprogrammingspinal canal |
| spellingShingle | Katerina Havelikova Barbora Smejkalova Pavla Jendelova Neurogenesis as a Tool for Spinal Cord Injury International Journal of Molecular Sciences neurogenesis spinal cord injury ependymal stem cells astrocytes reprogramming spinal canal |
| title | Neurogenesis as a Tool for Spinal Cord Injury |
| title_full | Neurogenesis as a Tool for Spinal Cord Injury |
| title_fullStr | Neurogenesis as a Tool for Spinal Cord Injury |
| title_full_unstemmed | Neurogenesis as a Tool for Spinal Cord Injury |
| title_short | Neurogenesis as a Tool for Spinal Cord Injury |
| title_sort | neurogenesis as a tool for spinal cord injury |
| topic | neurogenesis spinal cord injury ependymal stem cells astrocytes reprogramming spinal canal |
| url | https://www.mdpi.com/1422-0067/23/7/3728 |
| work_keys_str_mv | AT katerinahavelikova neurogenesisasatoolforspinalcordinjury AT barborasmejkalova neurogenesisasatoolforspinalcordinjury AT pavlajendelova neurogenesisasatoolforspinalcordinjury |