HYMENOPTERA ALLERGENS: FROM VENOM TO VENOME
In Western Europe hymenoptera venom allergy primarily relates to venoms of the honeybee and the common yellow jacket. In contrast to other allergen sources, only a few major components of hymenoptera venoms had been characterized until recently. Improved expression systems and proteomic detection s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00077/full |
| _version_ | 1818203033160384512 |
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| author | Edzard eSpillner Simon eBlank Thilo eJakob |
| author_facet | Edzard eSpillner Simon eBlank Thilo eJakob |
| author_sort | Edzard eSpillner |
| collection | DOAJ |
| description | In Western Europe hymenoptera venom allergy primarily relates to venoms of the honeybee and the common yellow jacket. In contrast to other allergen sources, only a few major components of hymenoptera venoms had been characterized until recently. Improved expression systems and proteomic detection strategies have allowed the identification and characterization of a wide range of additional allergens. The field of hymenoptera venom allergy research has moved rapidly from focusing on venom extract and single major allergens to a molecular understanding of the entire venome as a system of unique and characteristic components. <br/>An increasing number of such components has been identified, characterized regarding function and assessed for allergenic potential. Moreover, advanced expression strategies for recombinant production of venom allergens allow selective modification of molecules and provide insight into different types of IgE reactivities and sensitization patterns. The obtained information contributes to an increased diagnostic precision in hymenoptera venom allergy and may serve for monitoring, reevaluation and improvement of current therapeutic strategies.<br/> |
| first_indexed | 2024-12-12T03:18:54Z |
| format | Article |
| id | doaj.art-3368c654b8e845faa8f68db792c11ff8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T03:18:54Z |
| publishDate | 2014-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3368c654b8e845faa8f68db792c11ff82022-12-22T00:40:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-02-01510.3389/fimmu.2014.0007775903HYMENOPTERA ALLERGENS: FROM VENOM TO VENOMEEdzard eSpillner0Simon eBlank1Thilo eJakob2Aarhus UniversityCenter of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, GermanyUniversity of FreiburgIn Western Europe hymenoptera venom allergy primarily relates to venoms of the honeybee and the common yellow jacket. In contrast to other allergen sources, only a few major components of hymenoptera venoms had been characterized until recently. Improved expression systems and proteomic detection strategies have allowed the identification and characterization of a wide range of additional allergens. The field of hymenoptera venom allergy research has moved rapidly from focusing on venom extract and single major allergens to a molecular understanding of the entire venome as a system of unique and characteristic components. <br/>An increasing number of such components has been identified, characterized regarding function and assessed for allergenic potential. Moreover, advanced expression strategies for recombinant production of venom allergens allow selective modification of molecules and provide insight into different types of IgE reactivities and sensitization patterns. The obtained information contributes to an increased diagnostic precision in hymenoptera venom allergy and may serve for monitoring, reevaluation and improvement of current therapeutic strategies.<br/>http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00077/fullallergysensitizationcross-reactivityrecombinant allergensinsect venom |
| spellingShingle | Edzard eSpillner Simon eBlank Thilo eJakob HYMENOPTERA ALLERGENS: FROM VENOM TO VENOME Frontiers in Immunology allergy sensitization cross-reactivity recombinant allergens insect venom |
| title | HYMENOPTERA ALLERGENS: FROM VENOM TO VENOME |
| title_full | HYMENOPTERA ALLERGENS: FROM VENOM TO VENOME |
| title_fullStr | HYMENOPTERA ALLERGENS: FROM VENOM TO VENOME |
| title_full_unstemmed | HYMENOPTERA ALLERGENS: FROM VENOM TO VENOME |
| title_short | HYMENOPTERA ALLERGENS: FROM VENOM TO VENOME |
| title_sort | hymenoptera allergens from venom to venome |
| topic | allergy sensitization cross-reactivity recombinant allergens insect venom |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00077/full |
| work_keys_str_mv | AT edzardespillner hymenopteraallergensfromvenomtovenome AT simoneblank hymenopteraallergensfromvenomtovenome AT thiloejakob hymenopteraallergensfromvenomtovenome |