The role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic stroke
The aim of the study was to determine the role of fetal proteins AFP, CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, CYFRA 21-1 in the pathogenesis of the development of clinically significant brain edema in patients with ischemic stroke. It is established that the level of CA 15-3 had the statistical sign...
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| Format: | Article |
| Language: | English |
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Peoples’ Friendship University of Russia (RUDN University)
2014-12-01
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| Series: | RUDN Journal of Medicine |
| Subjects: | |
| Online Access: | http://journals.rudn.ru/medicine/article/view/3134 |
| _version_ | 1819181545394536448 |
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| author | A A Arkhipkin O V Lyang A G Kochetov |
| author_facet | A A Arkhipkin O V Lyang A G Kochetov |
| author_sort | A A Arkhipkin |
| collection | DOAJ |
| description | The aim of the study was to determine the role of fetal proteins AFP, CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, CYFRA 21-1 in the pathogenesis of the development of clinically significant brain edema in patients with ischemic stroke. It is established that the level of CA 15-3 had the statistical significance of the impact on the development of brain edema, OR was 1,058 (95%CI 1,011-1,107, p = 0.015). The threshold value of CA 15-3 for the development of brain edema was 21,0 (95%CI 18,7-23,3) IU/ml. Reference interval for CA 15-3 in this study was 6,53 of 22.2 IU/ml. Increasing of the level of CA 15-3 above the 90 th percentile of the reference interval was interrelated with the risk of brain edema. This can be explained by the participation of CA 15-3, located mainly on the epithelial cells, in intercellular interactions cells of the blood-brain barrier, the violation of which leads to the development of vasogenic brain edema. |
| first_indexed | 2024-12-22T22:31:56Z |
| format | Article |
| id | doaj.art-336a23361b2c4f05b56f1896c0b3873a |
| institution | Directory Open Access Journal |
| issn | 2313-0245 2313-0261 |
| language | English |
| last_indexed | 2024-12-22T22:31:56Z |
| publishDate | 2014-12-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Medicine |
| spelling | doaj.art-336a23361b2c4f05b56f1896c0b3873a2022-12-21T18:10:26ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612014-12-010331363134The role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic strokeA A Arkhipkin0O V Lyang1A G Kochetov2ООО «Научный центр ЭФиС»Российский университет дружбы народовРоссийский университет дружбы народовThe aim of the study was to determine the role of fetal proteins AFP, CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, CYFRA 21-1 in the pathogenesis of the development of clinically significant brain edema in patients with ischemic stroke. It is established that the level of CA 15-3 had the statistical significance of the impact on the development of brain edema, OR was 1,058 (95%CI 1,011-1,107, p = 0.015). The threshold value of CA 15-3 for the development of brain edema was 21,0 (95%CI 18,7-23,3) IU/ml. Reference interval for CA 15-3 in this study was 6,53 of 22.2 IU/ml. Increasing of the level of CA 15-3 above the 90 th percentile of the reference interval was interrelated with the risk of brain edema. This can be explained by the participation of CA 15-3, located mainly on the epithelial cells, in intercellular interactions cells of the blood-brain barrier, the violation of which leads to the development of vasogenic brain edema.http://journals.rudn.ru/medicine/article/view/3134отек мозгаишемический инсультфетальные белкиСА 15-3 |
| spellingShingle | A A Arkhipkin O V Lyang A G Kochetov The role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic stroke RUDN Journal of Medicine отек мозга ишемический инсульт фетальные белки СА 15-3 |
| title | The role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic stroke |
| title_full | The role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic stroke |
| title_fullStr | The role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic stroke |
| title_full_unstemmed | The role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic stroke |
| title_short | The role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic stroke |
| title_sort | role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic stroke |
| topic | отек мозга ишемический инсульт фетальные белки СА 15-3 |
| url | http://journals.rudn.ru/medicine/article/view/3134 |
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