Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone
The aim of this study was to investigate the combined effects of mulberry leaf and oat bran on type 2 diabetes. Co-treatment of diabetic mice with mulberry leaf and oat bran for 28 days led to lower glucose level and better glucose tolerance capacity than either mulberry leaf or oat bran treatment....
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646461930427X |
| _version_ | 1818563193615679488 |
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| author | Teng-Gen Hu Peng Wen Jun Liu Xiao-Shan Long Sen-Tai Liao Hong Wu Yu-Xiao Zou |
| author_facet | Teng-Gen Hu Peng Wen Jun Liu Xiao-Shan Long Sen-Tai Liao Hong Wu Yu-Xiao Zou |
| author_sort | Teng-Gen Hu |
| collection | DOAJ |
| description | The aim of this study was to investigate the combined effects of mulberry leaf and oat bran on type 2 diabetes. Co-treatment of diabetic mice with mulberry leaf and oat bran for 28 days led to lower glucose level and better glucose tolerance capacity than either mulberry leaf or oat bran treatment. It was found that this combination resulted in more significant inhibitory effects on alanine transaminase and aspartate transaminase activities. Meanwhile, the enhancement on insulin receptor and glucokinase expressions and down-regulation on pyruvate carboxylase, phosphoenolpyruvate carboxykinase, and pyruvate dehydrogenase complex kinase expressions were also observed. Additionally, the combination increased the gut microbiota diversity, and reshaped the gut microbiota structure. Based on the above data, it is more feasible to affirm that the combined supplementation of mulberry leaf and oat bran is a potential adjuvant on the treatment of diabetes mellitus. |
| first_indexed | 2024-12-14T01:13:36Z |
| format | Article |
| id | doaj.art-336a4269657f45f6acd052b17f6f4bc7 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T01:13:36Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-336a4269657f45f6acd052b17f6f4bc72022-12-21T23:22:40ZengElsevierJournal of Functional Foods1756-46462019-10-0161Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran aloneTeng-Gen Hu0Peng Wen1Jun Liu2Xiao-Shan Long3Sen-Tai Liao4Hong Wu5Yu-Xiao Zou6Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, No. 133 Yiheng St., Dongguanzhuang Rd, Tianhe District, Guangzhou 510610, PR China; School of Food Science and Engineering, South China University of Technology/Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, No. 381 Wushan Rd, Tianhe District, Guangzhou 510641, PR ChinaSchool of Food Science and Engineering, South China University of Technology/Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, No. 381 Wushan Rd, Tianhe District, Guangzhou 510641, PR ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, No. 133 Yiheng St., Dongguanzhuang Rd, Tianhe District, Guangzhou 510610, PR ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, No. 133 Yiheng St., Dongguanzhuang Rd, Tianhe District, Guangzhou 510610, PR ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, No. 133 Yiheng St., Dongguanzhuang Rd, Tianhe District, Guangzhou 510610, PR ChinaSchool of Food Science and Engineering, South China University of Technology/Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, No. 381 Wushan Rd, Tianhe District, Guangzhou 510641, PR China; Corresponding authors.Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, No. 133 Yiheng St., Dongguanzhuang Rd, Tianhe District, Guangzhou 510610, PR China; Corresponding authors.The aim of this study was to investigate the combined effects of mulberry leaf and oat bran on type 2 diabetes. Co-treatment of diabetic mice with mulberry leaf and oat bran for 28 days led to lower glucose level and better glucose tolerance capacity than either mulberry leaf or oat bran treatment. It was found that this combination resulted in more significant inhibitory effects on alanine transaminase and aspartate transaminase activities. Meanwhile, the enhancement on insulin receptor and glucokinase expressions and down-regulation on pyruvate carboxylase, phosphoenolpyruvate carboxykinase, and pyruvate dehydrogenase complex kinase expressions were also observed. Additionally, the combination increased the gut microbiota diversity, and reshaped the gut microbiota structure. Based on the above data, it is more feasible to affirm that the combined supplementation of mulberry leaf and oat bran is a potential adjuvant on the treatment of diabetes mellitus.http://www.sciencedirect.com/science/article/pii/S175646461930427XMulberry leafOat branHypoglycemicGlucose metabolismGut microbiotaCombined effects |
| spellingShingle | Teng-Gen Hu Peng Wen Jun Liu Xiao-Shan Long Sen-Tai Liao Hong Wu Yu-Xiao Zou Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone Journal of Functional Foods Mulberry leaf Oat bran Hypoglycemic Glucose metabolism Gut microbiota Combined effects |
| title | Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone |
| title_full | Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone |
| title_fullStr | Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone |
| title_full_unstemmed | Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone |
| title_short | Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone |
| title_sort | combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone |
| topic | Mulberry leaf Oat bran Hypoglycemic Glucose metabolism Gut microbiota Combined effects |
| url | http://www.sciencedirect.com/science/article/pii/S175646461930427X |
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