Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles
To overcome cancer, various chemotherapeutic studies are in progress; among these, studies on nano-formulated combinatorial drugs (NFCDs) are being actively pursued. NFCDs function via a fusion technology that includes a drug delivery system using nanoparticles as a carrier and a combinatorial drug...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/12/1156 |
| _version_ | 1797546449321328640 |
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| author | Moon Sup Yoon Yu Jin Lee Hee Ji Shin Chun-Woong Park Sang-Bae Han Jae-Kyung Jung Jin-Seok Kim Dae Hwan Shin |
| author_facet | Moon Sup Yoon Yu Jin Lee Hee Ji Shin Chun-Woong Park Sang-Bae Han Jae-Kyung Jung Jin-Seok Kim Dae Hwan Shin |
| author_sort | Moon Sup Yoon |
| collection | DOAJ |
| description | To overcome cancer, various chemotherapeutic studies are in progress; among these, studies on nano-formulated combinatorial drugs (NFCDs) are being actively pursued. NFCDs function via a fusion technology that includes a drug delivery system using nanoparticles as a carrier and a combinatorial drug therapy using two or more drugs. It not only includes the advantages of these two technologies, such as ensuring stability of drugs, selectively transporting drugs to cancer cells, and synergistic effects of two or more drugs, but also has the additional benefit of enabling the spatiotemporal and controlled release of drugs. This spatial and temporal drug release from NFCDs depends on the application of nanotechnology and the composition of the combination drug. In this review, recent advances and challenges in the control of spatiotemporal drug release from NFCDs are provided. To this end, the types of combinatorial drug release for various NFCDs are classified in terms of time and space, and the detailed programming techniques used for this are described. In addition, the advantages of the time and space differences in drug release in terms of anticancer efficacy are introduced in depth. |
| first_indexed | 2024-03-10T14:29:48Z |
| format | Article |
| id | doaj.art-336a4f3407dc47fcae8db0a3b6385466 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T14:29:48Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-336a4f3407dc47fcae8db0a3b63854662023-11-20T22:41:34ZengMDPI AGPharmaceutics1999-49232020-11-011212115610.3390/pharmaceutics12121156Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from NanoparticlesMoon Sup Yoon0Yu Jin Lee1Hee Ji Shin2Chun-Woong Park3Sang-Bae Han4Jae-Kyung Jung5Jin-Seok Kim6Dae Hwan Shin7College of Pharmacy, Chungbuk National University, Cheongju 28160, KoreaCollege of Pharmacy, Chungbuk National University, Cheongju 28160, KoreaCollege of Pharmacy, Chungbuk National University, Cheongju 28160, KoreaCollege of Pharmacy, Chungbuk National University, Cheongju 28160, KoreaCollege of Pharmacy, Chungbuk National University, Cheongju 28160, KoreaCollege of Pharmacy, Chungbuk National University, Cheongju 28160, KoreaDrug Information Research Institute, College of Pharmacy, Sookmyung Women’s University, Seoul 04310, KoreaCollege of Pharmacy, Chungbuk National University, Cheongju 28160, KoreaTo overcome cancer, various chemotherapeutic studies are in progress; among these, studies on nano-formulated combinatorial drugs (NFCDs) are being actively pursued. NFCDs function via a fusion technology that includes a drug delivery system using nanoparticles as a carrier and a combinatorial drug therapy using two or more drugs. It not only includes the advantages of these two technologies, such as ensuring stability of drugs, selectively transporting drugs to cancer cells, and synergistic effects of two or more drugs, but also has the additional benefit of enabling the spatiotemporal and controlled release of drugs. This spatial and temporal drug release from NFCDs depends on the application of nanotechnology and the composition of the combination drug. In this review, recent advances and challenges in the control of spatiotemporal drug release from NFCDs are provided. To this end, the types of combinatorial drug release for various NFCDs are classified in terms of time and space, and the detailed programming techniques used for this are described. In addition, the advantages of the time and space differences in drug release in terms of anticancer efficacy are introduced in depth.https://www.mdpi.com/1999-4923/12/12/1156nano-formulated combinatorial drugratiometricsequentialspatiotemporalcontrolled release |
| spellingShingle | Moon Sup Yoon Yu Jin Lee Hee Ji Shin Chun-Woong Park Sang-Bae Han Jae-Kyung Jung Jin-Seok Kim Dae Hwan Shin Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles Pharmaceutics nano-formulated combinatorial drug ratiometric sequential spatiotemporal controlled release |
| title | Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles |
| title_full | Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles |
| title_fullStr | Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles |
| title_full_unstemmed | Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles |
| title_short | Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles |
| title_sort | recent advances and challenges in controlling the spatiotemporal release of combinatorial anticancer drugs from nanoparticles |
| topic | nano-formulated combinatorial drug ratiometric sequential spatiotemporal controlled release |
| url | https://www.mdpi.com/1999-4923/12/12/1156 |
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