Pyrimidine analogues for the management of neurodegenerative diseases
Neurodegenerative diseases are one of the leading causes of mortality worldwide. Currently available therapeutic agents provide symptomatic relief to a great level. Still, there is a need for some more potential leads to overcome the progression of neurodegeneration. Pyrimidine scaffold has gained s...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | European Journal of Medicinal Chemistry Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S277241742200067X |
| _version_ | 1828116084390100992 |
|---|---|
| author | Swati Pant Anandi Kapri Sumitra Nain |
| author_facet | Swati Pant Anandi Kapri Sumitra Nain |
| author_sort | Swati Pant |
| collection | DOAJ |
| description | Neurodegenerative diseases are one of the leading causes of mortality worldwide. Currently available therapeutic agents provide symptomatic relief to a great level. Still, there is a need for some more potential leads to overcome the progression of neurodegeneration. Pyrimidine scaffold has gained substantial attention for the management of neurodegeneration due to its prominent role in the brain by improving cognitive functions. Recently, pyrimidine-containing compounds have been successfully developed as potent inhibitors of several biological targets involved in different neurodegenerative diseases. This present review provides insight into the beneficiary role of pyrimidine against these diseases with a particular focus on alzheimer's disease, parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, diabetic neuropathy, and multiple sclerosis. These findings may aid researchers in the design of more bio-target-specific anti-neurodegenerative agents. |
| first_indexed | 2024-04-11T12:51:34Z |
| format | Article |
| id | doaj.art-336b40aba3564353ae57bff83b11f697 |
| institution | Directory Open Access Journal |
| issn | 2772-4174 |
| language | English |
| last_indexed | 2024-04-11T12:51:34Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Medicinal Chemistry Reports |
| spelling | doaj.art-336b40aba3564353ae57bff83b11f6972022-12-22T04:23:12ZengElsevierEuropean Journal of Medicinal Chemistry Reports2772-41742022-12-016100095Pyrimidine analogues for the management of neurodegenerative diseasesSwati Pant0Anandi Kapri1Sumitra Nain2Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, IndiaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, IndiaCorresponding author.; Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, IndiaNeurodegenerative diseases are one of the leading causes of mortality worldwide. Currently available therapeutic agents provide symptomatic relief to a great level. Still, there is a need for some more potential leads to overcome the progression of neurodegeneration. Pyrimidine scaffold has gained substantial attention for the management of neurodegeneration due to its prominent role in the brain by improving cognitive functions. Recently, pyrimidine-containing compounds have been successfully developed as potent inhibitors of several biological targets involved in different neurodegenerative diseases. This present review provides insight into the beneficiary role of pyrimidine against these diseases with a particular focus on alzheimer's disease, parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, diabetic neuropathy, and multiple sclerosis. These findings may aid researchers in the design of more bio-target-specific anti-neurodegenerative agents.http://www.sciencedirect.com/science/article/pii/S277241742200067XPyrimidineNeurodegenerationAlzheimer's diseaseParkinson's diseaseHuntington's diseaseAmyotrophic lateral sclerosis |
| spellingShingle | Swati Pant Anandi Kapri Sumitra Nain Pyrimidine analogues for the management of neurodegenerative diseases European Journal of Medicinal Chemistry Reports Pyrimidine Neurodegeneration Alzheimer's disease Parkinson's disease Huntington's disease Amyotrophic lateral sclerosis |
| title | Pyrimidine analogues for the management of neurodegenerative diseases |
| title_full | Pyrimidine analogues for the management of neurodegenerative diseases |
| title_fullStr | Pyrimidine analogues for the management of neurodegenerative diseases |
| title_full_unstemmed | Pyrimidine analogues for the management of neurodegenerative diseases |
| title_short | Pyrimidine analogues for the management of neurodegenerative diseases |
| title_sort | pyrimidine analogues for the management of neurodegenerative diseases |
| topic | Pyrimidine Neurodegeneration Alzheimer's disease Parkinson's disease Huntington's disease Amyotrophic lateral sclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S277241742200067X |
| work_keys_str_mv | AT swatipant pyrimidineanaloguesforthemanagementofneurodegenerativediseases AT anandikapri pyrimidineanaloguesforthemanagementofneurodegenerativediseases AT sumitranain pyrimidineanaloguesforthemanagementofneurodegenerativediseases |