Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review
Abstract Corticobasal syndrome (CBS) is a clinical syndrome determined by various underlying neurodegenerative disorders requiring a pathological assessment for a definitive diagnosis. A literature review was performed following the methodology described in the Cochrane Handbook for Systematic Revie...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | Neurological Research and Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42466-023-00294-0 |
| _version_ | 1827387983694659584 |
|---|---|
| author | Giulia Remoli Edoardo Dalmato Schilke Andrea Magi Antonio Ancidoni Giulia Negro Fulvio Da Re Maura Frigo Martina Giordano Nicola Vanacore Marco Canevelli Carlo Ferrarese Lucio Tremolizzo Ildebrando Appollonio |
| author_facet | Giulia Remoli Edoardo Dalmato Schilke Andrea Magi Antonio Ancidoni Giulia Negro Fulvio Da Re Maura Frigo Martina Giordano Nicola Vanacore Marco Canevelli Carlo Ferrarese Lucio Tremolizzo Ildebrando Appollonio |
| author_sort | Giulia Remoli |
| collection | DOAJ |
| description | Abstract Corticobasal syndrome (CBS) is a clinical syndrome determined by various underlying neurodegenerative disorders requiring a pathological assessment for a definitive diagnosis. A literature review was performed following the methodology described in the Cochrane Handbook for Systematic Reviews to investigate the additional value of traditional and cutting-edge cerebrospinal fluid (CSF) and serum/plasma biomarkers in profiling CBS. Four databases were screened applying predefined inclusion criteria: (1) recruiting patients with CBS; (2) analyzing CSF/plasma biomarkers in CBS. The review highlights the potential role of the association of fluid biomarkers in diagnostic workup of CBS, since they may contribute to a more accurate diagnosis and patient selection for future disease-modifying agent; for example, future trial designs should consider baseline CSF Neurofilament Light Chains (NfL) or progranulin dosage to stratify treatment arms according to neuropathological substrates, and serum NfL dosage might be used to monitor the evolution of CBS. In this scenario, prospective cohort studies, starting with neurological examination and neuropsychological tests, should be considered to assess the correlations of clinical profiles and various biomarkers. |
| first_indexed | 2024-03-08T16:11:09Z |
| format | Article |
| id | doaj.art-336bafdf62e84c498c6d852b2f697c77 |
| institution | Directory Open Access Journal |
| issn | 2524-3489 |
| language | English |
| last_indexed | 2024-03-08T16:11:09Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Neurological Research and Practice |
| spelling | doaj.art-336bafdf62e84c498c6d852b2f697c772024-01-07T12:55:45ZengBMCNeurological Research and Practice2524-34892024-01-016111510.1186/s42466-023-00294-0Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic reviewGiulia Remoli0Edoardo Dalmato Schilke1Andrea Magi2Antonio Ancidoni3Giulia Negro4Fulvio Da Re5Maura Frigo6Martina Giordano7Nicola Vanacore8Marco Canevelli9Carlo Ferrarese10Lucio Tremolizzo11Ildebrando Appollonio12Neurology Department, Fondazione IRCCS San Gerardi dei Tintori, San Gerardo HospitalNeurology Department, Fondazione IRCCS San Gerardi dei Tintori, San Gerardo HospitalNeurology Department, Fondazione IRCCS San Gerardi dei Tintori, San Gerardo HospitalNational Institute of HealthNeurology Department, Fondazione IRCCS San Gerardi dei Tintori, San Gerardo HospitalNeurology Department, Fondazione IRCCS San Gerardi dei Tintori, San Gerardo HospitalNeurology Department, Fondazione IRCCS San Gerardi dei Tintori, San Gerardo HospitalNeurosurgery Unit, Department of Neuroscience, ASST Grande Ospedale Metropolitano NiguardaNational Institute of HealthNational Institute of HealthNeurology Department, Fondazione IRCCS San Gerardi dei Tintori, San Gerardo HospitalNeurology Department, Fondazione IRCCS San Gerardi dei Tintori, San Gerardo HospitalNeurology Department, Fondazione IRCCS San Gerardi dei Tintori, San Gerardo HospitalAbstract Corticobasal syndrome (CBS) is a clinical syndrome determined by various underlying neurodegenerative disorders requiring a pathological assessment for a definitive diagnosis. A literature review was performed following the methodology described in the Cochrane Handbook for Systematic Reviews to investigate the additional value of traditional and cutting-edge cerebrospinal fluid (CSF) and serum/plasma biomarkers in profiling CBS. Four databases were screened applying predefined inclusion criteria: (1) recruiting patients with CBS; (2) analyzing CSF/plasma biomarkers in CBS. The review highlights the potential role of the association of fluid biomarkers in diagnostic workup of CBS, since they may contribute to a more accurate diagnosis and patient selection for future disease-modifying agent; for example, future trial designs should consider baseline CSF Neurofilament Light Chains (NfL) or progranulin dosage to stratify treatment arms according to neuropathological substrates, and serum NfL dosage might be used to monitor the evolution of CBS. In this scenario, prospective cohort studies, starting with neurological examination and neuropsychological tests, should be considered to assess the correlations of clinical profiles and various biomarkers.https://doi.org/10.1186/s42466-023-00294-0Corticobasal syndromeFluid biomarkersCBS biomarkersCBS neuropathologyDementia biomarkers |
| spellingShingle | Giulia Remoli Edoardo Dalmato Schilke Andrea Magi Antonio Ancidoni Giulia Negro Fulvio Da Re Maura Frigo Martina Giordano Nicola Vanacore Marco Canevelli Carlo Ferrarese Lucio Tremolizzo Ildebrando Appollonio Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review Neurological Research and Practice Corticobasal syndrome Fluid biomarkers CBS biomarkers CBS neuropathology Dementia biomarkers |
| title | Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review |
| title_full | Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review |
| title_fullStr | Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review |
| title_full_unstemmed | Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review |
| title_short | Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review |
| title_sort | neuropathological hints from csf and serum biomarkers in corticobasal syndrome cbs a systematic review |
| topic | Corticobasal syndrome Fluid biomarkers CBS biomarkers CBS neuropathology Dementia biomarkers |
| url | https://doi.org/10.1186/s42466-023-00294-0 |
| work_keys_str_mv | AT giuliaremoli neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT edoardodalmatoschilke neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT andreamagi neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT antonioancidoni neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT giulianegro neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT fulviodare neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT maurafrigo neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT martinagiordano neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT nicolavanacore neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT marcocanevelli neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT carloferrarese neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT luciotremolizzo neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview AT ildebrandoappollonio neuropathologicalhintsfromcsfandserumbiomarkersincorticobasalsyndromecbsasystematicreview |