Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote Osteogenesis
Osteoporosis is one of the most disabling consequences of aging, and osteoporotic fractures and a higher risk of subsequent fractures lead to substantial disability and deaths, indicating that both local fracture healing and early anti-osteoporosis therapy are of great significance. However, combini...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/9/4/302 |
| _version_ | 1797605349849563136 |
|---|---|
| author | Yazhou Wang Zhiwei Peng Dong Zhang Dianwen Song |
| author_facet | Yazhou Wang Zhiwei Peng Dong Zhang Dianwen Song |
| author_sort | Yazhou Wang |
| collection | DOAJ |
| description | Osteoporosis is one of the most disabling consequences of aging, and osteoporotic fractures and a higher risk of subsequent fractures lead to substantial disability and deaths, indicating that both local fracture healing and early anti-osteoporosis therapy are of great significance. However, combining simple clinically approved materials to achieve good injection and subsequent molding and provide good mechanical support remains a challenge. To meet this challenge, bioinspired by natural bone components, we develop appropriate interactions between inorganic biological scaffolds and organic osteogenic molecules, achieving a tough hydrogel that is both firmly loaded with calcium phosphate cement (CPC) and injectable. Here, the inorganic component CPC composed of biomimetic bone composition and the organic precursor, incorporating gelatin methacryloyl (GelMA) and N-Hydroxyethyl acrylamide (HEAA), endow the system with fast polymerization and crosslinking through ultraviolet (UV) photo-initiation. The GelMA-poly (N-Hydroxyethyl acrylamide) (GelMA-PHEAA) chemical and physical network formed in situ enhances the mechanical performances and maintains the bioactive characteristics of CPC. This tough biomimetic hydrogel combined with bioactive CPC is a new promising candidate for a commercial clinical material to help patients to survive osteoporotic fracture. |
| first_indexed | 2024-03-11T04:59:51Z |
| format | Article |
| id | doaj.art-336c0e3e6b144da2a82908ca426c252b |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T04:59:51Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-336c0e3e6b144da2a82908ca426c252b2023-11-17T19:21:31ZengMDPI AGGels2310-28612023-04-019430210.3390/gels9040302Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote OsteogenesisYazhou Wang0Zhiwei Peng1Dong Zhang2Dianwen Song3Department of Orthopedics, Shanghai General Hospital of Nanjing Medical University, Shanghai 201600, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, ChinaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USADepartment of Orthopedics, Shanghai General Hospital of Nanjing Medical University, Shanghai 201600, ChinaOsteoporosis is one of the most disabling consequences of aging, and osteoporotic fractures and a higher risk of subsequent fractures lead to substantial disability and deaths, indicating that both local fracture healing and early anti-osteoporosis therapy are of great significance. However, combining simple clinically approved materials to achieve good injection and subsequent molding and provide good mechanical support remains a challenge. To meet this challenge, bioinspired by natural bone components, we develop appropriate interactions between inorganic biological scaffolds and organic osteogenic molecules, achieving a tough hydrogel that is both firmly loaded with calcium phosphate cement (CPC) and injectable. Here, the inorganic component CPC composed of biomimetic bone composition and the organic precursor, incorporating gelatin methacryloyl (GelMA) and N-Hydroxyethyl acrylamide (HEAA), endow the system with fast polymerization and crosslinking through ultraviolet (UV) photo-initiation. The GelMA-poly (N-Hydroxyethyl acrylamide) (GelMA-PHEAA) chemical and physical network formed in situ enhances the mechanical performances and maintains the bioactive characteristics of CPC. This tough biomimetic hydrogel combined with bioactive CPC is a new promising candidate for a commercial clinical material to help patients to survive osteoporotic fracture.https://www.mdpi.com/2310-2861/9/4/302injectable hydrogelsosteogenesisbone cementbiocompatible polymers |
| spellingShingle | Yazhou Wang Zhiwei Peng Dong Zhang Dianwen Song Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote Osteogenesis Gels injectable hydrogels osteogenesis bone cement biocompatible polymers |
| title | Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote Osteogenesis |
| title_full | Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote Osteogenesis |
| title_fullStr | Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote Osteogenesis |
| title_full_unstemmed | Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote Osteogenesis |
| title_short | Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote Osteogenesis |
| title_sort | tough injectable calcium phosphate cement based composite hydrogels to promote osteogenesis |
| topic | injectable hydrogels osteogenesis bone cement biocompatible polymers |
| url | https://www.mdpi.com/2310-2861/9/4/302 |
| work_keys_str_mv | AT yazhouwang toughinjectablecalciumphosphatecementbasedcompositehydrogelstopromoteosteogenesis AT zhiweipeng toughinjectablecalciumphosphatecementbasedcompositehydrogelstopromoteosteogenesis AT dongzhang toughinjectablecalciumphosphatecementbasedcompositehydrogelstopromoteosteogenesis AT dianwensong toughinjectablecalciumphosphatecementbasedcompositehydrogelstopromoteosteogenesis |