Toxicity of metal-based nanoparticles: Challenges in the nano era
With the rapid progress of nanotechnology, various nanoparticles (NPs) have been applicated in our daily life. In the field of nanotechnology, metal-based NPs are an important component of engineered NPs, including metal and metal oxide NPs, with a variety of biomedical applications. However, the un...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1001572/full |
| _version_ | 1797978480050176000 |
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| author | Naiding Zhang Guiya Xiong Zhenjie Liu |
| author_facet | Naiding Zhang Guiya Xiong Zhenjie Liu |
| author_sort | Naiding Zhang |
| collection | DOAJ |
| description | With the rapid progress of nanotechnology, various nanoparticles (NPs) have been applicated in our daily life. In the field of nanotechnology, metal-based NPs are an important component of engineered NPs, including metal and metal oxide NPs, with a variety of biomedical applications. However, the unique physicochemical properties of metal-based NPs confer not only promising biological effects but also pose unexpected toxic threats to human body at the same time. For safer application of metal-based NPs in humans, we should have a comprehensive understanding of NP toxicity. In this review, we summarize our current knowledge about metal-based NPs, including the physicochemical properties affecting their toxicity, mechanisms of their toxicity, their toxicological assessment, the potential strategies to mitigate their toxicity and current status of regulatory movement on their toxicity. Hopefully, in the near future, through the convergence of related disciplines, the development of nanotoxicity research will be significantly promoted, thereby making the application of metal-based NPs in humans much safer. |
| first_indexed | 2024-04-11T05:23:38Z |
| format | Article |
| id | doaj.art-336e61e040de4095b81b3301bbd1a091 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T05:23:38Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-336e61e040de4095b81b3301bbd1a0912022-12-23T12:05:06ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-11-011010.3389/fbioe.2022.10015721001572Toxicity of metal-based nanoparticles: Challenges in the nano eraNaiding Zhang0Guiya Xiong1Zhenjie Liu2Department of Vascular Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Science and Research, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Vascular Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaWith the rapid progress of nanotechnology, various nanoparticles (NPs) have been applicated in our daily life. In the field of nanotechnology, metal-based NPs are an important component of engineered NPs, including metal and metal oxide NPs, with a variety of biomedical applications. However, the unique physicochemical properties of metal-based NPs confer not only promising biological effects but also pose unexpected toxic threats to human body at the same time. For safer application of metal-based NPs in humans, we should have a comprehensive understanding of NP toxicity. In this review, we summarize our current knowledge about metal-based NPs, including the physicochemical properties affecting their toxicity, mechanisms of their toxicity, their toxicological assessment, the potential strategies to mitigate their toxicity and current status of regulatory movement on their toxicity. Hopefully, in the near future, through the convergence of related disciplines, the development of nanotoxicity research will be significantly promoted, thereby making the application of metal-based NPs in humans much safer.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1001572/fullmetal-based nanoparticlephysicochemical propertynanotoxicitymechanismassessmentmitigation |
| spellingShingle | Naiding Zhang Guiya Xiong Zhenjie Liu Toxicity of metal-based nanoparticles: Challenges in the nano era Frontiers in Bioengineering and Biotechnology metal-based nanoparticle physicochemical property nanotoxicity mechanism assessment mitigation |
| title | Toxicity of metal-based nanoparticles: Challenges in the nano era |
| title_full | Toxicity of metal-based nanoparticles: Challenges in the nano era |
| title_fullStr | Toxicity of metal-based nanoparticles: Challenges in the nano era |
| title_full_unstemmed | Toxicity of metal-based nanoparticles: Challenges in the nano era |
| title_short | Toxicity of metal-based nanoparticles: Challenges in the nano era |
| title_sort | toxicity of metal based nanoparticles challenges in the nano era |
| topic | metal-based nanoparticle physicochemical property nanotoxicity mechanism assessment mitigation |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1001572/full |
| work_keys_str_mv | AT naidingzhang toxicityofmetalbasednanoparticleschallengesinthenanoera AT guiyaxiong toxicityofmetalbasednanoparticleschallengesinthenanoera AT zhenjieliu toxicityofmetalbasednanoparticleschallengesinthenanoera |