CD4<sup>+</sup> T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy
The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8<sup>+</sup> T cells because of their cytotoxic effector function; however, CD4<sup>+<...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/5/1114 |
| _version_ | 1797535136393199616 |
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| author | Sonja I. Buschow Diahann T. S. L. Jansen |
| author_facet | Sonja I. Buschow Diahann T. S. L. Jansen |
| author_sort | Sonja I. Buschow |
| collection | DOAJ |
| description | The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8<sup>+</sup> T cells because of their cytotoxic effector function; however, CD4<sup>+</sup> T cells are crucial in the proper development of these long-lasting effector CD8<sup>+</sup> T cells. In this review, we summarize what is known about CD4<sup>+</sup> T cells in chronic HBV infection and discuss the importance and opportunities of including CD4<sup>+</sup> T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV. |
| first_indexed | 2024-03-10T11:40:16Z |
| format | Article |
| id | doaj.art-336f498ef39a47928343995fe84bdf60 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:40:16Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-336f498ef39a47928343995fe84bdf602023-11-21T18:29:31ZengMDPI AGCells2073-44092021-05-01105111410.3390/cells10051114CD4<sup>+</sup> T Cells in Chronic Hepatitis B and T Cell-Directed ImmunotherapySonja I. Buschow0Diahann T. S. L. Jansen1Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The NetherlandsThe impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8<sup>+</sup> T cells because of their cytotoxic effector function; however, CD4<sup>+</sup> T cells are crucial in the proper development of these long-lasting effector CD8<sup>+</sup> T cells. In this review, we summarize what is known about CD4<sup>+</sup> T cells in chronic HBV infection and discuss the importance and opportunities of including CD4<sup>+</sup> T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.https://www.mdpi.com/2073-4409/10/5/1114CD4<sup>+</sup> T cellshepatitis B virusimmunotherapy |
| spellingShingle | Sonja I. Buschow Diahann T. S. L. Jansen CD4<sup>+</sup> T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy Cells CD4<sup>+</sup> T cells hepatitis B virus immunotherapy |
| title | CD4<sup>+</sup> T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy |
| title_full | CD4<sup>+</sup> T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy |
| title_fullStr | CD4<sup>+</sup> T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy |
| title_full_unstemmed | CD4<sup>+</sup> T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy |
| title_short | CD4<sup>+</sup> T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy |
| title_sort | cd4 sup sup t cells in chronic hepatitis b and t cell directed immunotherapy |
| topic | CD4<sup>+</sup> T cells hepatitis B virus immunotherapy |
| url | https://www.mdpi.com/2073-4409/10/5/1114 |
| work_keys_str_mv | AT sonjaibuschow cd4supsuptcellsinchronichepatitisbandtcelldirectedimmunotherapy AT diahanntsljansen cd4supsuptcellsinchronichepatitisbandtcelldirectedimmunotherapy |