Protein Lipoxidation: Basic Concepts and Emerging Roles
Protein lipoxidation is a non-enzymatic post-translational modification that consists of the covalent addition of reactive lipid species to proteins. This occurs under basal conditions but increases in situations associated with oxidative stress. Protein targets for lipoxidation include metabolic an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/2/295 |
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| author | Álvaro Viedma-Poyatos Patricia González-Jiménez Ophélie Langlois Idoia Company-Marín Corinne M. Spickett Dolores Pérez-Sala |
| author_facet | Álvaro Viedma-Poyatos Patricia González-Jiménez Ophélie Langlois Idoia Company-Marín Corinne M. Spickett Dolores Pérez-Sala |
| author_sort | Álvaro Viedma-Poyatos |
| collection | DOAJ |
| description | Protein lipoxidation is a non-enzymatic post-translational modification that consists of the covalent addition of reactive lipid species to proteins. This occurs under basal conditions but increases in situations associated with oxidative stress. Protein targets for lipoxidation include metabolic and signalling enzymes, cytoskeletal proteins, and transcription factors, among others. There is strong evidence for the involvement of protein lipoxidation in disease, including atherosclerosis, neurodegeneration, and cancer. Nevertheless, the involvement of lipoxidation in cellular regulatory mechanisms is less understood. Here we review basic aspects of protein lipoxidation and discuss several features that could support its role in cell signalling, including its selectivity, reversibility, and possibilities for regulation at the levels of the generation and/or detoxification of reactive lipids. Moreover, given the great structural variety of electrophilic lipid species, protein lipoxidation can contribute to the generation of multiple structurally and functionally diverse protein species. Finally, the nature of the lipoxidised proteins and residues provides a frameshift for a complex interplay with other post-translational modifications, including redox and redox-regulated modifications, such as oxidative modifications and phosphorylation, thus strengthening the importance of detailed knowledge of this process. |
| first_indexed | 2024-03-09T00:51:18Z |
| format | Article |
| id | doaj.art-3371eb94bf07447086aff96b165df14e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T00:51:18Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3371eb94bf07447086aff96b165df14e2023-12-11T17:09:50ZengMDPI AGAntioxidants2076-39212021-02-0110229510.3390/antiox10020295Protein Lipoxidation: Basic Concepts and Emerging RolesÁlvaro Viedma-Poyatos0Patricia González-Jiménez1Ophélie Langlois2Idoia Company-Marín3Corinne M. Spickett4Dolores Pérez-Sala5Department of Structural and Chemical Biology, Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (C.S.I.C.), 28040 Madrid, SpainDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (C.S.I.C.), 28040 Madrid, SpainCollege of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UKCollege of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UKCollege of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UKDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (C.S.I.C.), 28040 Madrid, SpainProtein lipoxidation is a non-enzymatic post-translational modification that consists of the covalent addition of reactive lipid species to proteins. This occurs under basal conditions but increases in situations associated with oxidative stress. Protein targets for lipoxidation include metabolic and signalling enzymes, cytoskeletal proteins, and transcription factors, among others. There is strong evidence for the involvement of protein lipoxidation in disease, including atherosclerosis, neurodegeneration, and cancer. Nevertheless, the involvement of lipoxidation in cellular regulatory mechanisms is less understood. Here we review basic aspects of protein lipoxidation and discuss several features that could support its role in cell signalling, including its selectivity, reversibility, and possibilities for regulation at the levels of the generation and/or detoxification of reactive lipids. Moreover, given the great structural variety of electrophilic lipid species, protein lipoxidation can contribute to the generation of multiple structurally and functionally diverse protein species. Finally, the nature of the lipoxidised proteins and residues provides a frameshift for a complex interplay with other post-translational modifications, including redox and redox-regulated modifications, such as oxidative modifications and phosphorylation, thus strengthening the importance of detailed knowledge of this process.https://www.mdpi.com/2076-3921/10/2/295lipoxidationelectrophilic lipidsoxidative stresscell signallingregulationselectivity |
| spellingShingle | Álvaro Viedma-Poyatos Patricia González-Jiménez Ophélie Langlois Idoia Company-Marín Corinne M. Spickett Dolores Pérez-Sala Protein Lipoxidation: Basic Concepts and Emerging Roles Antioxidants lipoxidation electrophilic lipids oxidative stress cell signalling regulation selectivity |
| title | Protein Lipoxidation: Basic Concepts and Emerging Roles |
| title_full | Protein Lipoxidation: Basic Concepts and Emerging Roles |
| title_fullStr | Protein Lipoxidation: Basic Concepts and Emerging Roles |
| title_full_unstemmed | Protein Lipoxidation: Basic Concepts and Emerging Roles |
| title_short | Protein Lipoxidation: Basic Concepts and Emerging Roles |
| title_sort | protein lipoxidation basic concepts and emerging roles |
| topic | lipoxidation electrophilic lipids oxidative stress cell signalling regulation selectivity |
| url | https://www.mdpi.com/2076-3921/10/2/295 |
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