Pathogenesis of atherosclerosis in peripheral artery disease for diabetes patients
Over 170 million people worldwide are diagnosed with diabetes and it’s estimated that the number will reach 370 million cases by 2030. Diabetes represents a major risk factor for all cardiovascular diseases with a high mortality rate. Furthermore, diabetes represents a risk factor for peripheral art...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2020-06-01
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| Series: | Romanian Journal of Medical Practice |
| Subjects: | |
| Online Access: | https://rjmp.com.ro/articles/2020.2/RJMP_2020_2_Art-02.pdf |
| _version_ | 1819019526183845888 |
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| author | Pavelina Mihaela ANDREI Maria Daniela TANASESCU Alexandru MINCA Andra-Elena BALCANGIU-STROESCU Daniela BALAN Andrada MIHAI Alexandra Maria LIMBAU Constantin IONESCU TIRGOVISTE |
| author_facet | Pavelina Mihaela ANDREI Maria Daniela TANASESCU Alexandru MINCA Andra-Elena BALCANGIU-STROESCU Daniela BALAN Andrada MIHAI Alexandra Maria LIMBAU Constantin IONESCU TIRGOVISTE |
| author_sort | Pavelina Mihaela ANDREI |
| collection | DOAJ |
| description | Over 170 million people worldwide are diagnosed with diabetes and it’s estimated that the number will reach 370 million cases by 2030. Diabetes represents a major risk factor for all cardiovascular diseases with a high mortality rate. Furthermore, diabetes represents a risk factor for peripheral artery disease (PAD) cases and its association leads to significant increase in risk for vascular and cardiac events at foot and leg level thus impacting the quality of life of the patient. The atherosclerosis which is found at the base of PAD pathogenesis results from accumulation of lipids and fibrous material between the tunica intima and tunica media vascular walls resulting in progressive constriction of the vessel’s flux. This phenomenon can lead to complications such as thrombosis or rupture of the atheroma plaque which results in occlusion of downstream vessels. Reducing the risk factors which contribute to the atherosclerosis pathogenesis such as endothelial dysfunction, increase in platelets activity, dyslipidemia, immunological and inflammatory factors as well as tobacco contributes to the reduction of atherothrombotic episodes with impact on the patient’s quality of life. |
| first_indexed | 2024-12-21T03:36:43Z |
| format | Article |
| id | doaj.art-33725c9ddec5492193643633767b9d8a |
| institution | Directory Open Access Journal |
| issn | 1842-8258 2069-6108 |
| language | English |
| last_indexed | 2024-12-21T03:36:43Z |
| publishDate | 2020-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Medical Practice |
| spelling | doaj.art-33725c9ddec5492193643633767b9d8a2022-12-21T19:17:18ZengAmaltea Medical Publishing HouseRomanian Journal of Medical Practice1842-82582069-61082020-06-0115213213610.37897/RJMP.2020.2.2Pathogenesis of atherosclerosis in peripheral artery disease for diabetes patientsPavelina Mihaela ANDREI0Maria Daniela TANASESCU1Alexandru MINCA2Andra-Elena BALCANGIU-STROESCU3Daniela BALAN4Andrada MIHAI5Alexandra Maria LIMBAU6Constantin IONESCU TIRGOVISTE7Faculty of Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, RomaniaFaculty of Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania; Department of Internal Medicine, University Emergency Hospital, Bucharest, RomaniaFaculty of Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania; Department of Internal Medicine, University Emergency Hospital, Bucharest, RomaniaFaculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; Department of Dialysis, Emergency University Hospital, Bucharest, RomaniaFaculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania Faculty of Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania; “N.C. Paulescu“ National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, RomaniaFaculty of Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania Faculty of Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania; “N.C. Paulescu“ National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, RomaniaOver 170 million people worldwide are diagnosed with diabetes and it’s estimated that the number will reach 370 million cases by 2030. Diabetes represents a major risk factor for all cardiovascular diseases with a high mortality rate. Furthermore, diabetes represents a risk factor for peripheral artery disease (PAD) cases and its association leads to significant increase in risk for vascular and cardiac events at foot and leg level thus impacting the quality of life of the patient. The atherosclerosis which is found at the base of PAD pathogenesis results from accumulation of lipids and fibrous material between the tunica intima and tunica media vascular walls resulting in progressive constriction of the vessel’s flux. This phenomenon can lead to complications such as thrombosis or rupture of the atheroma plaque which results in occlusion of downstream vessels. Reducing the risk factors which contribute to the atherosclerosis pathogenesis such as endothelial dysfunction, increase in platelets activity, dyslipidemia, immunological and inflammatory factors as well as tobacco contributes to the reduction of atherothrombotic episodes with impact on the patient’s quality of life.https://rjmp.com.ro/articles/2020.2/RJMP_2020_2_Art-02.pdfatherosclerosisperipheral artery diseasediabetes mellitus |
| spellingShingle | Pavelina Mihaela ANDREI Maria Daniela TANASESCU Alexandru MINCA Andra-Elena BALCANGIU-STROESCU Daniela BALAN Andrada MIHAI Alexandra Maria LIMBAU Constantin IONESCU TIRGOVISTE Pathogenesis of atherosclerosis in peripheral artery disease for diabetes patients Romanian Journal of Medical Practice atherosclerosis peripheral artery disease diabetes mellitus |
| title | Pathogenesis of atherosclerosis in peripheral artery disease for diabetes patients |
| title_full | Pathogenesis of atherosclerosis in peripheral artery disease for diabetes patients |
| title_fullStr | Pathogenesis of atherosclerosis in peripheral artery disease for diabetes patients |
| title_full_unstemmed | Pathogenesis of atherosclerosis in peripheral artery disease for diabetes patients |
| title_short | Pathogenesis of atherosclerosis in peripheral artery disease for diabetes patients |
| title_sort | pathogenesis of atherosclerosis in peripheral artery disease for diabetes patients |
| topic | atherosclerosis peripheral artery disease diabetes mellitus |
| url | https://rjmp.com.ro/articles/2020.2/RJMP_2020_2_Art-02.pdf |
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