B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles
Since their discovery nearly 40 years ago, B-1 cells have continued to challenge the boundaries between innate and adaptive immunity, as well as myeloid and lymphoid functions. This B-cell subset ensures early immunity in neonates before the development of conventional B (B-2) cells and respond to i...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Toxicology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2023.960861/full |
| _version_ | 1797844916269744128 |
|---|---|
| author | Léa Hiéronimus François Huaux |
| author_facet | Léa Hiéronimus François Huaux |
| author_sort | Léa Hiéronimus |
| collection | DOAJ |
| description | Since their discovery nearly 40 years ago, B-1 cells have continued to challenge the boundaries between innate and adaptive immunity, as well as myeloid and lymphoid functions. This B-cell subset ensures early immunity in neonates before the development of conventional B (B-2) cells and respond to immune injuries throughout life. B-1 cells are multifaceted and serve as natural- and induced-antibody-producing cells, phagocytic cells, antigen-presenting cells, and anti-/pro-inflammatory cytokine-releasing cells. This review retraces the origin of B-1 cells and their different roles in homeostatic and infectious conditions before focusing on pollutants comprising contact-sensitivity-inducing chemicals, endocrine disruptors, aryl hydrocarbon receptor (AHR) ligands, and reactive particles. |
| first_indexed | 2024-04-09T17:30:06Z |
| format | Article |
| id | doaj.art-3372ef25dfa640a0a5d6afa44324d002 |
| institution | Directory Open Access Journal |
| issn | 2673-3080 |
| language | English |
| last_indexed | 2024-04-09T17:30:06Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Toxicology |
| spelling | doaj.art-3372ef25dfa640a0a5d6afa44324d0022023-04-18T05:25:38ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802023-04-01510.3389/ftox.2023.960861960861B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particlesLéa HiéronimusFrançois HuauxSince their discovery nearly 40 years ago, B-1 cells have continued to challenge the boundaries between innate and adaptive immunity, as well as myeloid and lymphoid functions. This B-cell subset ensures early immunity in neonates before the development of conventional B (B-2) cells and respond to immune injuries throughout life. B-1 cells are multifaceted and serve as natural- and induced-antibody-producing cells, phagocytic cells, antigen-presenting cells, and anti-/pro-inflammatory cytokine-releasing cells. This review retraces the origin of B-1 cells and their different roles in homeostatic and infectious conditions before focusing on pollutants comprising contact-sensitivity-inducing chemicals, endocrine disruptors, aryl hydrocarbon receptor (AHR) ligands, and reactive particles.https://www.frontiersin.org/articles/10.3389/ftox.2023.960861/fullautoimmunityautoantibodygranulomainflammationB-1 lymphocytesB1 cells |
| spellingShingle | Léa Hiéronimus François Huaux B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles Frontiers in Toxicology autoimmunity autoantibody granuloma inflammation B-1 lymphocytes B1 cells |
| title | B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles |
| title_full | B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles |
| title_fullStr | B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles |
| title_full_unstemmed | B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles |
| title_short | B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles |
| title_sort | b 1 cells in immunotoxicology mechanisms underlying their response to chemicals and particles |
| topic | autoimmunity autoantibody granuloma inflammation B-1 lymphocytes B1 cells |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2023.960861/full |
| work_keys_str_mv | AT leahieronimus b1cellsinimmunotoxicologymechanismsunderlyingtheirresponsetochemicalsandparticles AT francoishuaux b1cellsinimmunotoxicologymechanismsunderlyingtheirresponsetochemicalsandparticles |