Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study
Background: The prophylactic administration of tranexamic acid has been shown to be appropriate for procedures with a high risk of perioperative bleeding in cardiac surgery and orthopaedics. In urology the ambiguous results have been reported. Our goal was to evaluate the effect of tranexamic acid a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karolinum Press
2020-01-01
|
| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/63/4/0176/ |
| _version_ | 1818599484232302592 |
|---|---|
| author | Michal Balík Josef Košina Petr Hušek Miloš Broďák Filip Čečka |
| author_facet | Michal Balík Josef Košina Petr Hušek Miloš Broďák Filip Čečka |
| author_sort | Michal Balík |
| collection | DOAJ |
| description | Background: The prophylactic administration of tranexamic acid has been shown to be appropriate for procedures with a high risk of perioperative bleeding in cardiac surgery and orthopaedics. In urology the ambiguous results have been reported. Our goal was to evaluate the effect of tranexamic acid administration in robotic-assisted radical prostatectomy (RARP). A pilot, prospective, double-blind, randomized study was conducted to evaluate this effect. Methods: The study included 100 patients who received RARP in the period from April 2017 to January 2018. The patients were randomly assigned to study and control groups of 50 patients each. Results: The median follow-up was 6 months. Lower haemoglobin level drop weighted for gram of operated prostate was observed in the study group when treating the dorsal vein complex (DVC) at the beginning of the procedure (p = 0.004 after 3 hours and p < 0.001 after 24 hours). There was no evidence of any serious side effect of tranexamic acid. Conclusion: We demonstrated the safety of tranexamic acid at RARP. In addition, we showed that administration of tranexamic acid at the beginning of RARP significantly reduces the decrease in haemoglobin after the procedure when treating the DVC at the beginning of the procedure. |
| first_indexed | 2024-12-16T12:20:19Z |
| format | Article |
| id | doaj.art-33748b545870413497f9f290be75d187 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-16T12:20:19Z |
| publishDate | 2020-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-33748b545870413497f9f290be75d1872022-12-21T22:32:00ZengKarolinum PressActa Medica1211-42861805-96942020-01-0163417618210.14712/18059694.2020.60Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot StudyMichal Balík0Josef Košina1Petr Hušek2Miloš Broďák3Filip Čečka4Department of Urology, Faculty of Medicine and University Hospital Hradec Králové, Czech RepublicDepartment of Urology, Faculty of Medicine and University Hospital Hradec Králové, Czech RepublicDepartment of Urology, Faculty of Medicine and University Hospital Hradec Králové, Czech RepublicDepartment of Urology, Faculty of Medicine and University Hospital Hradec Králové, Czech RepublicDepartment of Surgery, Faculty of Medicine and University Hospital Hradec Králové, Czech RepublicBackground: The prophylactic administration of tranexamic acid has been shown to be appropriate for procedures with a high risk of perioperative bleeding in cardiac surgery and orthopaedics. In urology the ambiguous results have been reported. Our goal was to evaluate the effect of tranexamic acid administration in robotic-assisted radical prostatectomy (RARP). A pilot, prospective, double-blind, randomized study was conducted to evaluate this effect. Methods: The study included 100 patients who received RARP in the period from April 2017 to January 2018. The patients were randomly assigned to study and control groups of 50 patients each. Results: The median follow-up was 6 months. Lower haemoglobin level drop weighted for gram of operated prostate was observed in the study group when treating the dorsal vein complex (DVC) at the beginning of the procedure (p = 0.004 after 3 hours and p < 0.001 after 24 hours). There was no evidence of any serious side effect of tranexamic acid. Conclusion: We demonstrated the safety of tranexamic acid at RARP. In addition, we showed that administration of tranexamic acid at the beginning of RARP significantly reduces the decrease in haemoglobin after the procedure when treating the DVC at the beginning of the procedure.https://actamedica.lfhk.cuni.cz/63/4/0176/tranexamic acidrobotic-assisted radical prostatectomyprostate carcinoma |
| spellingShingle | Michal Balík Josef Košina Petr Hušek Miloš Broďák Filip Čečka Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study Acta Medica tranexamic acid robotic-assisted radical prostatectomy prostate carcinoma |
| title | Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study |
| title_full | Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study |
| title_fullStr | Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study |
| title_full_unstemmed | Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study |
| title_short | Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study |
| title_sort | safety and efficacy of using tranexamic acid at the beginning of robotic assisted radical prostatectomy in a double blind prospective randomized pilot study |
| topic | tranexamic acid robotic-assisted radical prostatectomy prostate carcinoma |
| url | https://actamedica.lfhk.cuni.cz/63/4/0176/ |
| work_keys_str_mv | AT michalbalik safetyandefficacyofusingtranexamicacidatthebeginningofroboticassistedradicalprostatectomyinadoubleblindprospectiverandomizedpilotstudy AT josefkosina safetyandefficacyofusingtranexamicacidatthebeginningofroboticassistedradicalprostatectomyinadoubleblindprospectiverandomizedpilotstudy AT petrhusek safetyandefficacyofusingtranexamicacidatthebeginningofroboticassistedradicalprostatectomyinadoubleblindprospectiverandomizedpilotstudy AT milosbrodak safetyandefficacyofusingtranexamicacidatthebeginningofroboticassistedradicalprostatectomyinadoubleblindprospectiverandomizedpilotstudy AT filipcecka safetyandefficacyofusingtranexamicacidatthebeginningofroboticassistedradicalprostatectomyinadoubleblindprospectiverandomizedpilotstudy |