Clinical and Acoustic Alterations of Swallowing in Children Exposed to Zika Virus during Pregnancy in a Cohort in Amazonas, Brazil: A Case Series Study
Oropharyngeal dysphagia (OD) is a swallowing disorder that involves difficulty in safely passing the food bolus from the oral cavity to the stomach. OD is a common problem in children with congenital Zika virus syndrome (CZS). In this case series, we describe the clinical and acoustic alterations of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/12/2363 |
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| author | Cristina de Souza Rodrigues Raillon Keven Santos Souza Cosmo Vieira Rocha Neto Rodrigo Haruo Otani Daniel de Medeiros Batista Ana Karla Nelson de Oliveira Maia Kleber Pinheiro de Oliveira Filho Thais Dourado de Andrade Emmilyn de Andrade Almeida Luiz Henrique Gonçalves Maciel Lucíola de Fátima Albuquerque Almeida Peixoto Castro Marília Rosa Abtibol-Bernardino Djane Clarys Baia-da-Silva Silvana Gomes Benzecry Marcia da Costa Castilho Flor Ernestina Martínez-Espinosa Maria das Graças Costa Alecrim Rosane Sampaio Santos Camila Botto-Menezes |
| author_facet | Cristina de Souza Rodrigues Raillon Keven Santos Souza Cosmo Vieira Rocha Neto Rodrigo Haruo Otani Daniel de Medeiros Batista Ana Karla Nelson de Oliveira Maia Kleber Pinheiro de Oliveira Filho Thais Dourado de Andrade Emmilyn de Andrade Almeida Luiz Henrique Gonçalves Maciel Lucíola de Fátima Albuquerque Almeida Peixoto Castro Marília Rosa Abtibol-Bernardino Djane Clarys Baia-da-Silva Silvana Gomes Benzecry Marcia da Costa Castilho Flor Ernestina Martínez-Espinosa Maria das Graças Costa Alecrim Rosane Sampaio Santos Camila Botto-Menezes |
| author_sort | Cristina de Souza Rodrigues |
| collection | DOAJ |
| description | Oropharyngeal dysphagia (OD) is a swallowing disorder that involves difficulty in safely passing the food bolus from the oral cavity to the stomach. OD is a common problem in children with congenital Zika virus syndrome (CZS). In this case series, we describe the clinical and acoustic alterations of swallowing in children exposed to the Zika virus during pregnancy in a cohort from Amazonas, Brazil. From July 2019 to January 2020, 22 children were evaluated, 6 with microcephaly and 16 without microcephaly. The mean age among the participants was 35 months (±4.6 months). All children with microcephaly had alterations in oral motricity, mainly in the lips and cheeks. Other alterations were in vocal quality, hard palate, and soft palate. Half of the children with microcephaly showed changes in cervical auscultation during breast milk swallowing. In children without microcephaly, the most frequently observed alteration was in lip motricity, but alterations in auscultation during the swallowing of breast milk were not observed. Regarding swallowing food of a liquid and pasty consistency, the most frequent alterations were incomplete verbal closure, increased oral transit time, inadequacy in capturing the spoon, anterior labial leakage, and increased oral transit time. Although these events are more frequent in microcephalic children, they can also be seen in non-microcephalic children, which points to the need for an indistinct evaluation of children exposed in utero to ZIKV. |
| first_indexed | 2024-03-08T20:16:54Z |
| format | Article |
| id | doaj.art-3375372b7fb34b8c90d87db30e2f0415 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-08T20:16:54Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-3375372b7fb34b8c90d87db30e2f04152023-12-22T14:49:12ZengMDPI AGViruses1999-49152023-11-011512236310.3390/v15122363Clinical and Acoustic Alterations of Swallowing in Children Exposed to Zika Virus during Pregnancy in a Cohort in Amazonas, Brazil: A Case Series StudyCristina de Souza Rodrigues0Raillon Keven Santos Souza1Cosmo Vieira Rocha Neto2Rodrigo Haruo Otani3Daniel de Medeiros Batista4Ana Karla Nelson de Oliveira Maia5Kleber Pinheiro de Oliveira Filho6Thais Dourado de Andrade7Emmilyn de Andrade Almeida8Luiz Henrique Gonçalves Maciel9Lucíola de Fátima Albuquerque Almeida Peixoto Castro10Marília Rosa Abtibol-Bernardino11Djane Clarys Baia-da-Silva12Silvana Gomes Benzecry13Marcia da Costa Castilho14Flor Ernestina Martínez-Espinosa15Maria das Graças Costa Alecrim16Rosane Sampaio Santos17Camila Botto-Menezes18Postgraduate Program in Tropical Medicine (PPGMT), University of Amazonas State (UEA), Manaus 69040-000, BrazilNorthern University Center (UniNorte), Manaus 69020-160, BrazilSchool of Health Sciences, University of Amazonas State, Manaus 69065-001, BrazilSchool of Health Sciences, University of Amazonas State, Manaus 69065-001, BrazilSchool of Health Sciences, University of Amazonas State, Manaus 69065-001, BrazilSchool of Health Sciences, University of Amazonas State, Manaus 69065-001, BrazilFaculty of Pharmacy, University Nilton Lins, Manaus 69058-030, BrazilFaculty of Pharmacy, University Nilton Lins, Manaus 69058-030, BrazilEast Zone Children’s Emergency Hospital, Manaus 69058-030, BrazilPostgraduate Program in Tropical Medicine (PPGMT), University of Amazonas State (UEA), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), University of Amazonas State (UEA), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), University of Amazonas State (UEA), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), University of Amazonas State (UEA), Manaus 69040-000, BrazilSchool of Health Sciences, University of Amazonas State, Manaus 69065-001, BrazilTropical Medicine Foundation Doutor Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), University of Amazonas State (UEA), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), University of Amazonas State (UEA), Manaus 69040-000, BrazilPostgraduate Program in Communication Disorders (PPGDIC), University of Tuiuti do Paraná (UTP), Paraná 82010-210, BrazilPostgraduate Program in Tropical Medicine (PPGMT), University of Amazonas State (UEA), Manaus 69040-000, BrazilOropharyngeal dysphagia (OD) is a swallowing disorder that involves difficulty in safely passing the food bolus from the oral cavity to the stomach. OD is a common problem in children with congenital Zika virus syndrome (CZS). In this case series, we describe the clinical and acoustic alterations of swallowing in children exposed to the Zika virus during pregnancy in a cohort from Amazonas, Brazil. From July 2019 to January 2020, 22 children were evaluated, 6 with microcephaly and 16 without microcephaly. The mean age among the participants was 35 months (±4.6 months). All children with microcephaly had alterations in oral motricity, mainly in the lips and cheeks. Other alterations were in vocal quality, hard palate, and soft palate. Half of the children with microcephaly showed changes in cervical auscultation during breast milk swallowing. In children without microcephaly, the most frequently observed alteration was in lip motricity, but alterations in auscultation during the swallowing of breast milk were not observed. Regarding swallowing food of a liquid and pasty consistency, the most frequent alterations were incomplete verbal closure, increased oral transit time, inadequacy in capturing the spoon, anterior labial leakage, and increased oral transit time. Although these events are more frequent in microcephalic children, they can also be seen in non-microcephalic children, which points to the need for an indistinct evaluation of children exposed in utero to ZIKV.https://www.mdpi.com/1999-4915/15/12/2363<i>Zika virus</i>arboviruscongenital <i>Zika virus</i> syndromeoropharyngeal dysphagianon-microcephalic children |
| spellingShingle | Cristina de Souza Rodrigues Raillon Keven Santos Souza Cosmo Vieira Rocha Neto Rodrigo Haruo Otani Daniel de Medeiros Batista Ana Karla Nelson de Oliveira Maia Kleber Pinheiro de Oliveira Filho Thais Dourado de Andrade Emmilyn de Andrade Almeida Luiz Henrique Gonçalves Maciel Lucíola de Fátima Albuquerque Almeida Peixoto Castro Marília Rosa Abtibol-Bernardino Djane Clarys Baia-da-Silva Silvana Gomes Benzecry Marcia da Costa Castilho Flor Ernestina Martínez-Espinosa Maria das Graças Costa Alecrim Rosane Sampaio Santos Camila Botto-Menezes Clinical and Acoustic Alterations of Swallowing in Children Exposed to Zika Virus during Pregnancy in a Cohort in Amazonas, Brazil: A Case Series Study Viruses <i>Zika virus</i> arbovirus congenital <i>Zika virus</i> syndrome oropharyngeal dysphagia non-microcephalic children |
| title | Clinical and Acoustic Alterations of Swallowing in Children Exposed to Zika Virus during Pregnancy in a Cohort in Amazonas, Brazil: A Case Series Study |
| title_full | Clinical and Acoustic Alterations of Swallowing in Children Exposed to Zika Virus during Pregnancy in a Cohort in Amazonas, Brazil: A Case Series Study |
| title_fullStr | Clinical and Acoustic Alterations of Swallowing in Children Exposed to Zika Virus during Pregnancy in a Cohort in Amazonas, Brazil: A Case Series Study |
| title_full_unstemmed | Clinical and Acoustic Alterations of Swallowing in Children Exposed to Zika Virus during Pregnancy in a Cohort in Amazonas, Brazil: A Case Series Study |
| title_short | Clinical and Acoustic Alterations of Swallowing in Children Exposed to Zika Virus during Pregnancy in a Cohort in Amazonas, Brazil: A Case Series Study |
| title_sort | clinical and acoustic alterations of swallowing in children exposed to zika virus during pregnancy in a cohort in amazonas brazil a case series study |
| topic | <i>Zika virus</i> arbovirus congenital <i>Zika virus</i> syndrome oropharyngeal dysphagia non-microcephalic children |
| url | https://www.mdpi.com/1999-4915/15/12/2363 |
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