Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patient
Familial hypercholesterolemia (FH; OMIM: # 143890) is a common inherited autosomal dominant disease, characterized by high-level low-density lipoprotein cholesterol (LDL-C) in plasma. Elevated LDL-C levels is closely related with atherosclerotic plaques and premature cardiovascular disease if not tr...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-03-01
|
| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506121004712 |
| _version_ | 1818330297365692416 |
|---|---|
| author | Zijuan Qi Yazhou Cui Liang Shi Jing Wang Qingyang Zhao Jing Luan Jinxiang Han |
| author_facet | Zijuan Qi Yazhou Cui Liang Shi Jing Wang Qingyang Zhao Jing Luan Jinxiang Han |
| author_sort | Zijuan Qi |
| collection | DOAJ |
| description | Familial hypercholesterolemia (FH; OMIM: # 143890) is a common inherited autosomal dominant disease, characterized by high-level low-density lipoprotein cholesterol (LDL-C) in plasma. Elevated LDL-C levels is closely related with atherosclerotic plaques and premature cardiovascular disease if not treated in time. Here we generated an induced pluripotent stem cell (iPSC) line using urine cells (UCs) derived from an 8-year-old male FH patient who carrying two coding and pathogenic mutations of low-density lipoprotein receptor (LDLR) gene (exon12:c.C1747T and exon13: c. 1948 del G). This induced pluripotent stem cell line named SMBCi009-A can be used to understand more cellular details about FH. |
| first_indexed | 2024-12-13T13:01:43Z |
| format | Article |
| id | doaj.art-337601a37b6c45d59b46db982d78adf6 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-12-13T13:01:43Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-337601a37b6c45d59b46db982d78adf62022-12-21T23:44:59ZengElsevierStem Cell Research1873-50612022-03-0159102624Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patientZijuan Qi0Yazhou Cui1Liang Shi2Jing Wang3Qingyang Zhao4Jing Luan5Jinxiang Han6Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, China; Corresponding author at: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji'nan, Shandong, China.Familial hypercholesterolemia (FH; OMIM: # 143890) is a common inherited autosomal dominant disease, characterized by high-level low-density lipoprotein cholesterol (LDL-C) in plasma. Elevated LDL-C levels is closely related with atherosclerotic plaques and premature cardiovascular disease if not treated in time. Here we generated an induced pluripotent stem cell (iPSC) line using urine cells (UCs) derived from an 8-year-old male FH patient who carrying two coding and pathogenic mutations of low-density lipoprotein receptor (LDLR) gene (exon12:c.C1747T and exon13: c. 1948 del G). This induced pluripotent stem cell line named SMBCi009-A can be used to understand more cellular details about FH.http://www.sciencedirect.com/science/article/pii/S1873506121004712 |
| spellingShingle | Zijuan Qi Yazhou Cui Liang Shi Jing Wang Qingyang Zhao Jing Luan Jinxiang Han Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patient Stem Cell Research |
| title | Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patient |
| title_full | Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patient |
| title_fullStr | Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patient |
| title_full_unstemmed | Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patient |
| title_short | Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patient |
| title_sort | generation of a non integrated induced pluripotent stem cell line smbci009 a from urine derived cells of a chinese familial hypercholesterolemia patient |
| url | http://www.sciencedirect.com/science/article/pii/S1873506121004712 |
| work_keys_str_mv | AT zijuanqi generationofanonintegratedinducedpluripotentstemcelllinesmbci009afromurinederivedcellsofachinesefamilialhypercholesterolemiapatient AT yazhoucui generationofanonintegratedinducedpluripotentstemcelllinesmbci009afromurinederivedcellsofachinesefamilialhypercholesterolemiapatient AT liangshi generationofanonintegratedinducedpluripotentstemcelllinesmbci009afromurinederivedcellsofachinesefamilialhypercholesterolemiapatient AT jingwang generationofanonintegratedinducedpluripotentstemcelllinesmbci009afromurinederivedcellsofachinesefamilialhypercholesterolemiapatient AT qingyangzhao generationofanonintegratedinducedpluripotentstemcelllinesmbci009afromurinederivedcellsofachinesefamilialhypercholesterolemiapatient AT jingluan generationofanonintegratedinducedpluripotentstemcelllinesmbci009afromurinederivedcellsofachinesefamilialhypercholesterolemiapatient AT jinxianghan generationofanonintegratedinducedpluripotentstemcelllinesmbci009afromurinederivedcellsofachinesefamilialhypercholesterolemiapatient |