A cortical disinhibitory circuit for enhancing adult plasticity
The adult brain continues to learn and can recover from injury, but the elements and operation of the neural circuits responsible for this plasticity are not known. In previous work, we have shown that locomotion dramatically enhances neural activity in the visual cortex (V1) of the mouse (Niell and...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2015-01-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/05558 |
| _version_ | 1797997546340089856 |
|---|---|
| author | Yu Fu Megumi Kaneko Yunshuo Tang Arturo Alvarez-Buylla Michael P Stryker |
| author_facet | Yu Fu Megumi Kaneko Yunshuo Tang Arturo Alvarez-Buylla Michael P Stryker |
| author_sort | Yu Fu |
| collection | DOAJ |
| description | The adult brain continues to learn and can recover from injury, but the elements and operation of the neural circuits responsible for this plasticity are not known. In previous work, we have shown that locomotion dramatically enhances neural activity in the visual cortex (V1) of the mouse (Niell and Stryker, 2010), identified the cortical circuit responsible for this enhancement (Fu et al., 2014), and shown that locomotion also dramatically enhances adult plasticity (Kaneko and Stryker, 2014). The circuit that is responsible for enhancing neural activity in the visual cortex contains both vasoactive intestinal peptide (VIP) and somatostatin (SST) neurons (Fu et al., 2014). Here, we ask whether this VIP-SST circuit enhances plasticity directly, independent of locomotion and aerobic activity. Optogenetic activation or genetic blockade of this circuit reveals that it is both necessary and sufficient for rapidly increasing V1 cortical responses following manipulation of visual experience in adult mice. These findings reveal a disinhibitory circuit that regulates adult cortical plasticity. |
| first_indexed | 2024-04-11T10:33:27Z |
| format | Article |
| id | doaj.art-3377be34daff43ffb6e72ebde0424d6e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T10:33:27Z |
| publishDate | 2015-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-3377be34daff43ffb6e72ebde0424d6e2022-12-22T04:29:21ZengeLife Sciences Publications LtdeLife2050-084X2015-01-01410.7554/eLife.05558A cortical disinhibitory circuit for enhancing adult plasticityYu Fu0Megumi Kaneko1Yunshuo Tang2Arturo Alvarez-Buylla3Michael P Stryker4Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, United StatesCenter for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, United StatesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, United States; The Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, San Francisco, United States; Medical Scientist Training Program, Biomedical Science Program, University of California, San Francisco, San Francisco, United StatesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, United States; The Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, San Francisco, United StatesCenter for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, United StatesThe adult brain continues to learn and can recover from injury, but the elements and operation of the neural circuits responsible for this plasticity are not known. In previous work, we have shown that locomotion dramatically enhances neural activity in the visual cortex (V1) of the mouse (Niell and Stryker, 2010), identified the cortical circuit responsible for this enhancement (Fu et al., 2014), and shown that locomotion also dramatically enhances adult plasticity (Kaneko and Stryker, 2014). The circuit that is responsible for enhancing neural activity in the visual cortex contains both vasoactive intestinal peptide (VIP) and somatostatin (SST) neurons (Fu et al., 2014). Here, we ask whether this VIP-SST circuit enhances plasticity directly, independent of locomotion and aerobic activity. Optogenetic activation or genetic blockade of this circuit reveals that it is both necessary and sufficient for rapidly increasing V1 cortical responses following manipulation of visual experience in adult mice. These findings reveal a disinhibitory circuit that regulates adult cortical plasticity.https://elifesciences.org/articles/05558visual cortexneural plasticityVIP cellsomatostatin cellcritical periodadult plasticty |
| spellingShingle | Yu Fu Megumi Kaneko Yunshuo Tang Arturo Alvarez-Buylla Michael P Stryker A cortical disinhibitory circuit for enhancing adult plasticity eLife visual cortex neural plasticity VIP cell somatostatin cell critical period adult plasticty |
| title | A cortical disinhibitory circuit for enhancing adult plasticity |
| title_full | A cortical disinhibitory circuit for enhancing adult plasticity |
| title_fullStr | A cortical disinhibitory circuit for enhancing adult plasticity |
| title_full_unstemmed | A cortical disinhibitory circuit for enhancing adult plasticity |
| title_short | A cortical disinhibitory circuit for enhancing adult plasticity |
| title_sort | cortical disinhibitory circuit for enhancing adult plasticity |
| topic | visual cortex neural plasticity VIP cell somatostatin cell critical period adult plasticty |
| url | https://elifesciences.org/articles/05558 |
| work_keys_str_mv | AT yufu acorticaldisinhibitorycircuitforenhancingadultplasticity AT megumikaneko acorticaldisinhibitorycircuitforenhancingadultplasticity AT yunshuotang acorticaldisinhibitorycircuitforenhancingadultplasticity AT arturoalvarezbuylla acorticaldisinhibitorycircuitforenhancingadultplasticity AT michaelpstryker acorticaldisinhibitorycircuitforenhancingadultplasticity AT yufu corticaldisinhibitorycircuitforenhancingadultplasticity AT megumikaneko corticaldisinhibitorycircuitforenhancingadultplasticity AT yunshuotang corticaldisinhibitorycircuitforenhancingadultplasticity AT arturoalvarezbuylla corticaldisinhibitorycircuitforenhancingadultplasticity AT michaelpstryker corticaldisinhibitorycircuitforenhancingadultplasticity |