Co-occurrence of myeloid neoplasm and plasma cell neoplasm
Co-occurrence of myelodysplastic syndrome (MDS) and plasma cell neoplasm in patients with no history of chemo and/or radiotherapy is rarely reported. Herein, we report a case of a female in her seventieth decade of life who was referred to the hospital for pancytopenia. The patient was asymptomatic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2022-07-01
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| Series: | Autopsy and Case Reports |
| Subjects: | |
| Online Access: | https://www.revistas.usp.br/autopsy/article/view/200307 |
| _version_ | 1818189538045984768 |
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| author | Husam Jum’ah Yan Wang Salman Ayub |
| author_facet | Husam Jum’ah Yan Wang Salman Ayub |
| author_sort | Husam Jum’ah |
| collection | DOAJ |
| description |
Co-occurrence of myelodysplastic syndrome (MDS) and plasma cell neoplasm in patients with no history of chemo and/or radiotherapy is rarely reported. Herein, we report a case of a female in her seventieth decade of life who was referred to the hospital for pancytopenia. The patient was asymptomatic and was doing well overall. Serum protein electrophoresis was remarkable for a lambda-restricted monoclonal protein (IgG) estimated at 1.8g/dL. Immunoglobulin G serum level was also elevated, and serum Kappa/Lambda free light chain ratio was decreased. At that time, a bone marrow biopsy showed myelodysplastic syndrome with excess blasts-2 (MDS-EB2) and a monoclonal plasma cell proliferation. Some studies have shown that patients with plasma cell neoplasm could be associated with an increased risk of developing MDS compared to the general population. Based on reviewing the literature, to our knowledge, the pathological mechanism of the co-occurrence of both diseases is not yet clear.
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| first_indexed | 2024-12-11T23:44:24Z |
| format | Article |
| id | doaj.art-3377ea97d29e42259e77e6f8bac3a0de |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-12-11T23:44:24Z |
| publishDate | 2022-07-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-3377ea97d29e42259e77e6f8bac3a0de2022-12-22T00:45:39ZengUniversity of São PauloAutopsy and Case Reports2236-19602022-07-0112Co-occurrence of myeloid neoplasm and plasma cell neoplasmHusam Jum’ah0Yan Wang1Salman Ayub2MetroHealth Medical Center, Department of Pathology, Cleveland, Ohio, USAMetroHealth Medical Center, Department of Pathology, Cleveland, Ohio, USAMetroHealth Medical Center, Department of Pathology, Cleveland, Ohio, USA Co-occurrence of myelodysplastic syndrome (MDS) and plasma cell neoplasm in patients with no history of chemo and/or radiotherapy is rarely reported. Herein, we report a case of a female in her seventieth decade of life who was referred to the hospital for pancytopenia. The patient was asymptomatic and was doing well overall. Serum protein electrophoresis was remarkable for a lambda-restricted monoclonal protein (IgG) estimated at 1.8g/dL. Immunoglobulin G serum level was also elevated, and serum Kappa/Lambda free light chain ratio was decreased. At that time, a bone marrow biopsy showed myelodysplastic syndrome with excess blasts-2 (MDS-EB2) and a monoclonal plasma cell proliferation. Some studies have shown that patients with plasma cell neoplasm could be associated with an increased risk of developing MDS compared to the general population. Based on reviewing the literature, to our knowledge, the pathological mechanism of the co-occurrence of both diseases is not yet clear. https://www.revistas.usp.br/autopsy/article/view/200307Myelodysplastic SyndromesMonoclonal Gammopathy of Undetermined SignificanceSmoldering Multiple MyelomaBone MarrowPancytopenia |
| spellingShingle | Husam Jum’ah Yan Wang Salman Ayub Co-occurrence of myeloid neoplasm and plasma cell neoplasm Autopsy and Case Reports Myelodysplastic Syndromes Monoclonal Gammopathy of Undetermined Significance Smoldering Multiple Myeloma Bone Marrow Pancytopenia |
| title | Co-occurrence of myeloid neoplasm and plasma cell neoplasm |
| title_full | Co-occurrence of myeloid neoplasm and plasma cell neoplasm |
| title_fullStr | Co-occurrence of myeloid neoplasm and plasma cell neoplasm |
| title_full_unstemmed | Co-occurrence of myeloid neoplasm and plasma cell neoplasm |
| title_short | Co-occurrence of myeloid neoplasm and plasma cell neoplasm |
| title_sort | co occurrence of myeloid neoplasm and plasma cell neoplasm |
| topic | Myelodysplastic Syndromes Monoclonal Gammopathy of Undetermined Significance Smoldering Multiple Myeloma Bone Marrow Pancytopenia |
| url | https://www.revistas.usp.br/autopsy/article/view/200307 |
| work_keys_str_mv | AT husamjumah cooccurrenceofmyeloidneoplasmandplasmacellneoplasm AT yanwang cooccurrenceofmyeloidneoplasmandplasmacellneoplasm AT salmanayub cooccurrenceofmyeloidneoplasmandplasmacellneoplasm |