Therapy of rheumatoid arthritis by reactive oxygen species-responsive celastrol-loaded nanomedicines via targeting macrophages apoptosis

Therapy of rheumatoid arthritis by reactive oxygen species-responsive celastrol-loaded nanomedicines via targeting macrophages apoptosis

Inflammatory cascade is a prevalent and lethal adverse event that severely affects rheumatoid arthritis (RA) patients receiving clinic therapeutics. It is correlated with the response to macrophages caused by reactive oxygen species (ROS). Currently, ROS-targeted treatment is a potential strategy th...

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Bibliographic Details
Main Authors: Sen Lin, Dahao Wang, Chang Xu, Peng Zhang, Kai Gao, Chang Liu, Xifan Mei
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Materials & Design
Subjects:
Rheumatoid arthritis
Reactive oxygen species
Macrophages
Apoptosis
Nanotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127522009200

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