lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans.
For the nervous system to develop properly, neurons must connect in a precise way to form functional networks. This requires that outgrowing neuronal processes (axons) navigate to their target areas, where they establish proper synaptic connections. The molecular basis of this navigation process is...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0278258 |
| _version_ | 1797958103698767872 |
|---|---|
| author | Nikolas Kokan Skyla Witt Saru Sandhu Harald Hutter |
| author_facet | Nikolas Kokan Skyla Witt Saru Sandhu Harald Hutter |
| author_sort | Nikolas Kokan |
| collection | DOAJ |
| description | For the nervous system to develop properly, neurons must connect in a precise way to form functional networks. This requires that outgrowing neuronal processes (axons) navigate to their target areas, where they establish proper synaptic connections. The molecular basis of this navigation process is not firmly understood. A candidate family containing putative receptors acting in various aspects of neuronal development including axon navigation are transmembrane proteins of the extracellular Leucine-Rich Repeat family (eLRRs). We systematically tested members of this family in C. elegans for a role in axon navigation in the ventral nerve cord (VNC). We found that lron-11 mutants showed VNC navigation defects in several classes of neurons, including a pioneer neuron and various classes of interneurons and motoneurons. This suggests that while most members of the lron-family do not seem to have a role in axon navigation in the VNC, lron-11 is likely to be a receptor required for correct navigation of axons in the VNC of C. elegans. |
| first_indexed | 2024-04-11T00:14:03Z |
| format | Article |
| id | doaj.art-33783b4a82714a7387e6dcc817781b0f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T00:14:03Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-33783b4a82714a7387e6dcc817781b0f2023-01-09T05:31:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011711e027825810.1371/journal.pone.0278258lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans.Nikolas KokanSkyla WittSaru SandhuHarald HutterFor the nervous system to develop properly, neurons must connect in a precise way to form functional networks. This requires that outgrowing neuronal processes (axons) navigate to their target areas, where they establish proper synaptic connections. The molecular basis of this navigation process is not firmly understood. A candidate family containing putative receptors acting in various aspects of neuronal development including axon navigation are transmembrane proteins of the extracellular Leucine-Rich Repeat family (eLRRs). We systematically tested members of this family in C. elegans for a role in axon navigation in the ventral nerve cord (VNC). We found that lron-11 mutants showed VNC navigation defects in several classes of neurons, including a pioneer neuron and various classes of interneurons and motoneurons. This suggests that while most members of the lron-family do not seem to have a role in axon navigation in the VNC, lron-11 is likely to be a receptor required for correct navigation of axons in the VNC of C. elegans.https://doi.org/10.1371/journal.pone.0278258 |
| spellingShingle | Nikolas Kokan Skyla Witt Saru Sandhu Harald Hutter lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans. PLoS ONE |
| title | lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans. |
| title_full | lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans. |
| title_fullStr | lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans. |
| title_full_unstemmed | lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans. |
| title_short | lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans. |
| title_sort | lron 11 guides axons in the ventral nerve cord of caenorhabditis elegans |
| url | https://doi.org/10.1371/journal.pone.0278258 |
| work_keys_str_mv | AT nikolaskokan lron11guidesaxonsintheventralnervecordofcaenorhabditiselegans AT skylawitt lron11guidesaxonsintheventralnervecordofcaenorhabditiselegans AT sarusandhu lron11guidesaxonsintheventralnervecordofcaenorhabditiselegans AT haraldhutter lron11guidesaxonsintheventralnervecordofcaenorhabditiselegans |