Multimodal vaccination targeting the receptor binding domains of Clostridioides difficile toxins A and B with an attenuated Salmonella Typhimurium vector (YS1646) protects mice from lethal challenge

Multimodal vaccination targeting the receptor binding domains of Clostridioides difficile toxins A and B with an attenuated Salmonella Typhimurium vector (YS1646) protects mice from lethal challenge

ABSTRACTDeveloping a vaccine against Clostridioides difficile is a key strategy to protect the elderly. Two candidate vaccines using a traditional approach of intramuscular (IM) delivery of recombinant antigens targeting C. difficile toxins A (TcdA) and B (TcdB) failed to meet their primary endpoint...

Full description

Bibliographic Details
Main Authors: Kaitlin Winter, Sébastien Houle, Charles M. Dozois, Brian J. Ward
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:Microbiology Spectrum
Subjects:
Clostridioides difficile
Salmonella Typhimurium
vaccination
chromosomal integration
mucosal immunity
humoral immunity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03109-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03109-22

Similar Items