Research progress on the pharmacological mechanism, in vivo metabolism and structural modification of Erianin
Erianin is an important bibenzyl compound in dendrobium and has a wide spectrum of pharmacological properties. Since Erianin was discovered, abundant results have been achieved in the in vitro synthesis, structural modification, and pharmacological mechanism research. Researchers have developed a se...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224001768 |
| _version_ | 1797248400315383808 |
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| author | Xin Wei Jiajia Liu Ziming Xu Dan Wang Qizhi Zhu Qi Chen Weiping Xu |
| author_facet | Xin Wei Jiajia Liu Ziming Xu Dan Wang Qizhi Zhu Qi Chen Weiping Xu |
| author_sort | Xin Wei |
| collection | DOAJ |
| description | Erianin is an important bibenzyl compound in dendrobium and has a wide spectrum of pharmacological properties. Since Erianin was discovered, abundant results have been achieved in the in vitro synthesis, structural modification, and pharmacological mechanism research. Researchers have developed a series of simple and efficient in vitro synthesis methods to improve the shortcomings of poor water solubility by replacing the chemical structure or coating it in nanomaterials. Erianin has a broad anti-tumor spectrum and significant anti-tumor effects. In addition, Erianin also has pharmacological actions like immune regulation, anti-inflammatory, and anti-angiogenesis. A comprehensive understanding of the synthesis, metabolism, structural modification, and pharmacological action pathways of Erianin is of great value for the utilization of Erianin. Therefore, this review conducts a relatively systematic look back at Erianin from the above four aspects, to give a reference for the evolvement and further appliance of Erianin. |
| first_indexed | 2024-03-07T22:00:55Z |
| format | Article |
| id | doaj.art-337d8b47015d4664aa774a13d8ee13bf |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-24T20:13:59Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-337d8b47015d4664aa774a13d8ee13bf2024-03-23T06:22:40ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-04-01173116295Research progress on the pharmacological mechanism, in vivo metabolism and structural modification of ErianinXin Wei0Jiajia Liu1Ziming Xu2Dan Wang3Qizhi Zhu4Qi Chen5Weiping Xu6Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China; University of Science and Technology of China, Hefei 230026, PR ChinaUniversity of Science and Technology of China, Hefei 230026, PR China; Department of Geriatrics, Gerontology Institute of Anhui Province, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR ChinaUniversity of Science and Technology of China, Hefei 230026, PR China; Department of Ophthalmology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230001, PR ChinaUniversity of Science and Technology of China, Hefei 230026, PR China; Department of Geriatrics, Gerontology Institute of Anhui Province, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR ChinaInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China; University of Science and Technology of China, Hefei 230026, PR ChinaInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China; University of Science and Technology of China, Hefei 230026, PR ChinaInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China; University of Science and Technology of China, Hefei 230026, PR China; Department of Geriatrics, Gerontology Institute of Anhui Province, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, PR China; Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei 230001, PR China; Corresponding author at: Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China.Erianin is an important bibenzyl compound in dendrobium and has a wide spectrum of pharmacological properties. Since Erianin was discovered, abundant results have been achieved in the in vitro synthesis, structural modification, and pharmacological mechanism research. Researchers have developed a series of simple and efficient in vitro synthesis methods to improve the shortcomings of poor water solubility by replacing the chemical structure or coating it in nanomaterials. Erianin has a broad anti-tumor spectrum and significant anti-tumor effects. In addition, Erianin also has pharmacological actions like immune regulation, anti-inflammatory, and anti-angiogenesis. A comprehensive understanding of the synthesis, metabolism, structural modification, and pharmacological action pathways of Erianin is of great value for the utilization of Erianin. Therefore, this review conducts a relatively systematic look back at Erianin from the above four aspects, to give a reference for the evolvement and further appliance of Erianin.http://www.sciencedirect.com/science/article/pii/S0753332224001768ErianinSynthesisMetabolismStructural modificationPharmacological effects |
| spellingShingle | Xin Wei Jiajia Liu Ziming Xu Dan Wang Qizhi Zhu Qi Chen Weiping Xu Research progress on the pharmacological mechanism, in vivo metabolism and structural modification of Erianin Biomedicine & Pharmacotherapy Erianin Synthesis Metabolism Structural modification Pharmacological effects |
| title | Research progress on the pharmacological mechanism, in vivo metabolism and structural modification of Erianin |
| title_full | Research progress on the pharmacological mechanism, in vivo metabolism and structural modification of Erianin |
| title_fullStr | Research progress on the pharmacological mechanism, in vivo metabolism and structural modification of Erianin |
| title_full_unstemmed | Research progress on the pharmacological mechanism, in vivo metabolism and structural modification of Erianin |
| title_short | Research progress on the pharmacological mechanism, in vivo metabolism and structural modification of Erianin |
| title_sort | research progress on the pharmacological mechanism in vivo metabolism and structural modification of erianin |
| topic | Erianin Synthesis Metabolism Structural modification Pharmacological effects |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224001768 |
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