<it>In vivo</it> functional brain mapping in a conditional mouse model of human tauopathy (<it>tau</it><sub>p301l</sub>) reveals reduced neural activity in memory formation structures

<it>In vivo</it> functional brain mapping in a conditional mouse model of human tauopathy (<it>tau</it><sub>p301l</sub>) reveals reduced neural activity in memory formation structures

<p>Abstract</p> <p>Background</p> <p>Tauopathies are characterized by intracellular deposition of the microtubule-associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally expresses mutant human tau protein in various forebrain areas under the Te...

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Bibliographic Details
Main Authors: Perez Pablo D, Hall Gabrielle, Kimura Tetsuya, Ren Yan, Bailey Rachel M, Lewis Jada, Febo Marcelo, Sahara Naruhiko
Format: Article
Language:English
Published: BMC 2013-02-01
Series:Molecular Neurodegeneration
Subjects:
Tauopathy
Neurodegenerative disease
Alzheimer’s disease
rTg4510
Manganese enhanced MRI
Online Access:http://www.molecularneurodegeneration.com/content/8/1/9

Internet

http://www.molecularneurodegeneration.com/content/8/1/9

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