Role of Inositols and Inositol Phosphates in Energy Metabolism
Recently, inositols, especially <i>myo</i>-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects. Although their roles in cancer treatment and prevention have...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/21/5079 |
| _version_ | 1797549094049153024 |
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| author | Saimai Chatree Nanthaphop Thongmaen Kwanchanit Tantivejkul Chantacha Sitticharoon Ivana Vucenik |
| author_facet | Saimai Chatree Nanthaphop Thongmaen Kwanchanit Tantivejkul Chantacha Sitticharoon Ivana Vucenik |
| author_sort | Saimai Chatree |
| collection | DOAJ |
| description | Recently, inositols, especially <i>myo</i>-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects. Although their roles in cancer treatment and prevention have been extensively reported, interestingly, they may also have distinctive properties in energy metabolism and metabolic disorders. We review inositols and inositol phosphate metabolism in mammalian cells to establish their biological activities and highlight their potential roles in energy metabolism. These molecules are known to decrease insulin resistance, increase insulin sensitivity, and have diverse properties with importance from cell signaling to metabolism. Evidence showed that inositol phosphates might enhance the browning of white adipocytes and directly improve insulin sensitivity through adipocytes. In addition, inositol pyrophosphates containing high-energy phosphate bonds are considered in increasing cellular energetics. Despite all recent advances, many aspects of the bioactivity of inositol phosphates are still not clear, especially their effects on insulin resistance and alteration of metabolism, so more research is needed. |
| first_indexed | 2024-03-10T15:09:43Z |
| format | Article |
| id | doaj.art-337dd52da6224a5c9dcd4049cf5dc484 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:09:43Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-337dd52da6224a5c9dcd4049cf5dc4842023-11-20T19:27:42ZengMDPI AGMolecules1420-30492020-11-012521507910.3390/molecules25215079Role of Inositols and Inositol Phosphates in Energy MetabolismSaimai Chatree0Nanthaphop Thongmaen1Kwanchanit Tantivejkul2Chantacha Sitticharoon3Ivana Vucenik4Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok 10210, ThailandDepartment of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandSugavia Co., Ltd., Nakhonratchasima 30130, ThailandDepartment of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Medical and Research Technology, School of Medicine, University of Maryland, Baltimore, MD 21201, USARecently, inositols, especially <i>myo</i>-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects. Although their roles in cancer treatment and prevention have been extensively reported, interestingly, they may also have distinctive properties in energy metabolism and metabolic disorders. We review inositols and inositol phosphate metabolism in mammalian cells to establish their biological activities and highlight their potential roles in energy metabolism. These molecules are known to decrease insulin resistance, increase insulin sensitivity, and have diverse properties with importance from cell signaling to metabolism. Evidence showed that inositol phosphates might enhance the browning of white adipocytes and directly improve insulin sensitivity through adipocytes. In addition, inositol pyrophosphates containing high-energy phosphate bonds are considered in increasing cellular energetics. Despite all recent advances, many aspects of the bioactivity of inositol phosphates are still not clear, especially their effects on insulin resistance and alteration of metabolism, so more research is needed.https://www.mdpi.com/1420-3049/25/21/5079inositol phosphates<i>myo</i>-inositolIP6energy metabolisminsulin resistance |
| spellingShingle | Saimai Chatree Nanthaphop Thongmaen Kwanchanit Tantivejkul Chantacha Sitticharoon Ivana Vucenik Role of Inositols and Inositol Phosphates in Energy Metabolism Molecules inositol phosphates <i>myo</i>-inositol IP6 energy metabolism insulin resistance |
| title | Role of Inositols and Inositol Phosphates in Energy Metabolism |
| title_full | Role of Inositols and Inositol Phosphates in Energy Metabolism |
| title_fullStr | Role of Inositols and Inositol Phosphates in Energy Metabolism |
| title_full_unstemmed | Role of Inositols and Inositol Phosphates in Energy Metabolism |
| title_short | Role of Inositols and Inositol Phosphates in Energy Metabolism |
| title_sort | role of inositols and inositol phosphates in energy metabolism |
| topic | inositol phosphates <i>myo</i>-inositol IP6 energy metabolism insulin resistance |
| url | https://www.mdpi.com/1420-3049/25/21/5079 |
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