Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine?
Background: Major depressive disorder is associated with inflammation and immune processes. Depressive symptoms correlate with inflammatory markers and alterations in the immune system including cytokine levels and immune cell function. Th17 cells are a T cell subset which exerts proinflammatory eff...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.649144/full |
| _version_ | 1818361811423985664 |
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| author | Meiying Cui Wanlin Dai Jing Kong Hongzhi Chen |
| author_facet | Meiying Cui Wanlin Dai Jing Kong Hongzhi Chen |
| author_sort | Meiying Cui |
| collection | DOAJ |
| description | Background: Major depressive disorder is associated with inflammation and immune processes. Depressive symptoms correlate with inflammatory markers and alterations in the immune system including cytokine levels and immune cell function. Th17 cells are a T cell subset which exerts proinflammatory effects. Th17 cell accumulation and Th17/Treg imbalances have been reported to be critical in the pathophysiology of major depressive disorder and depressive-like behaviors in animal models. Th17 cells are thought to interfere with glutamate signaling, dopamine production, and other immune processes. Ketamine is a newly characterized antidepressant medication which has proved to be effective in rapidly reducing depressive symptoms. However, the mechanisms behind these antidepressant effects have not been fully elucidated.Method: Literature about Th17 cells and their role in depression and the antidepressant effect of ketamine are reviewed, with the possible interaction networks discussed.Result: The immune-modulating role of Th17 cells may participate in the antidepressant effect of ketamine.Conclusion: As Th17 cells play multiple roles in depression, it is important to explore the mechanisms of action of ketamine on Th17 cells and Th17/Treg cell balance. This provides new perspectives for strengthening the antidepressant effect of ketamine while reducing its side effects and adverse reactions. |
| first_indexed | 2024-12-13T21:22:37Z |
| format | Article |
| id | doaj.art-3380a5a5a21c42f8943d81b3cef40a9e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T21:22:37Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3380a5a5a21c42f8943d81b3cef40a9e2022-12-21T23:31:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-04-011210.3389/fphar.2021.649144649144Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine?Meiying Cui0Wanlin Dai1Jing Kong2Hongzhi Chen3Department of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, ChinaInnovation Institute of China Medical University, Shenyang, ChinaDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, ChinaBackground: Major depressive disorder is associated with inflammation and immune processes. Depressive symptoms correlate with inflammatory markers and alterations in the immune system including cytokine levels and immune cell function. Th17 cells are a T cell subset which exerts proinflammatory effects. Th17 cell accumulation and Th17/Treg imbalances have been reported to be critical in the pathophysiology of major depressive disorder and depressive-like behaviors in animal models. Th17 cells are thought to interfere with glutamate signaling, dopamine production, and other immune processes. Ketamine is a newly characterized antidepressant medication which has proved to be effective in rapidly reducing depressive symptoms. However, the mechanisms behind these antidepressant effects have not been fully elucidated.Method: Literature about Th17 cells and their role in depression and the antidepressant effect of ketamine are reviewed, with the possible interaction networks discussed.Result: The immune-modulating role of Th17 cells may participate in the antidepressant effect of ketamine.Conclusion: As Th17 cells play multiple roles in depression, it is important to explore the mechanisms of action of ketamine on Th17 cells and Th17/Treg cell balance. This provides new perspectives for strengthening the antidepressant effect of ketamine while reducing its side effects and adverse reactions.https://www.frontiersin.org/articles/10.3389/fphar.2021.649144/fullketamineth17 celldepressionimmunecytokine |
| spellingShingle | Meiying Cui Wanlin Dai Jing Kong Hongzhi Chen Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine? Frontiers in Pharmacology ketamine th17 cell depression immune cytokine |
| title | Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine? |
| title_full | Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine? |
| title_fullStr | Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine? |
| title_full_unstemmed | Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine? |
| title_short | Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine? |
| title_sort | th17 cells in depression are they crucial for the antidepressant effect of ketamine |
| topic | ketamine th17 cell depression immune cytokine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.649144/full |
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