Effect of maternal fluoxetine exposure on lung, heart and kidney development in rat neonates
Objective(s): Depression during pregnancy negatively affects fetal development. Fluoxetine as a selective serotonin reuptake inhibitor (SSRIs) is used for treatment of gestational depression. This study is trying to determine the effects of fluoxetine on the renal, heart and lung development.Materia...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2018-04-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_10365_da69f2e18f7ee4c7f21f33569bea2a26.pdf |
| _version_ | 1819032728575672320 |
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| author | Razieh Taghizadeh Ghvamabadi Zahra Taghipour Mahsa Hasanipoor Marzieh Khademi Mehdi Shariati |
| author_facet | Razieh Taghizadeh Ghvamabadi Zahra Taghipour Mahsa Hasanipoor Marzieh Khademi Mehdi Shariati |
| author_sort | Razieh Taghizadeh Ghvamabadi |
| collection | DOAJ |
| description | Objective(s): Depression during pregnancy negatively affects fetal development. Fluoxetine as a selective serotonin reuptake inhibitor (SSRIs) is used for treatment of gestational depression. This study is trying to determine the effects of fluoxetine on the renal, heart and lung development.Materials and Methods: Fifteen pregnant rats were treated with fluoxetine at 7 mg/kg from days 0 to 21 of gestation. Immediately after born, heart and kidney samples were evaluated for genes expression and histological assessment. Lung sample were fixed for immunohistochemical study.Results: The gene expression of BMP7 and WNT4 were reduced in the kidney of fluoxetine-treated group (P-value0.05). Histological assessment showed that the glomeruli of the kidneys in treated group are more primordial compared to control. There was a developmental deficiency in Bowman’s capsule, and the capsular space was not clear. The arrangements of the filaments, the position of the nucleus and cells morphology were normal in the hearts of both groups. Immunohistochemical analysis demonstrated that in the fluoxetine-exposed group HoxB5 is more expressed in the mesenchymal cells, but in the control group the expression is limited to alveolar cells.Conclusion: According to developmental changes in kidney, heart and lung, fluoxetine affects neonatal growth during pregnancy, which may lead to delay of some organs growth. So, it is essential to survey the roles of antidepressant drugs on fatal and neonatal development during pregnancy. |
| first_indexed | 2024-12-21T07:06:33Z |
| format | Article |
| id | doaj.art-3380d61c7f874d1ea89c125aa4406630 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-21T07:06:33Z |
| publishDate | 2018-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-3380d61c7f874d1ea89c125aa44066302022-12-21T19:12:06ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742018-04-0121441742110.22038/ijbms.2018.27203.665010365Effect of maternal fluoxetine exposure on lung, heart and kidney development in rat neonatesRazieh Taghizadeh Ghvamabadi0Zahra Taghipour1Mahsa Hasanipoor2Marzieh Khademi3Mehdi Shariati4Department of Anatomy, School of Medicine; Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Anatomy, School of Medicine; Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Physiology-Pharmacology, School of Medicine; Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Anatomy, School of Medicine; Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Anatomy, School of Medicine; Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IranObjective(s): Depression during pregnancy negatively affects fetal development. Fluoxetine as a selective serotonin reuptake inhibitor (SSRIs) is used for treatment of gestational depression. This study is trying to determine the effects of fluoxetine on the renal, heart and lung development.Materials and Methods: Fifteen pregnant rats were treated with fluoxetine at 7 mg/kg from days 0 to 21 of gestation. Immediately after born, heart and kidney samples were evaluated for genes expression and histological assessment. Lung sample were fixed for immunohistochemical study.Results: The gene expression of BMP7 and WNT4 were reduced in the kidney of fluoxetine-treated group (P-value0.05). Histological assessment showed that the glomeruli of the kidneys in treated group are more primordial compared to control. There was a developmental deficiency in Bowman’s capsule, and the capsular space was not clear. The arrangements of the filaments, the position of the nucleus and cells morphology were normal in the hearts of both groups. Immunohistochemical analysis demonstrated that in the fluoxetine-exposed group HoxB5 is more expressed in the mesenchymal cells, but in the control group the expression is limited to alveolar cells.Conclusion: According to developmental changes in kidney, heart and lung, fluoxetine affects neonatal growth during pregnancy, which may lead to delay of some organs growth. So, it is essential to survey the roles of antidepressant drugs on fatal and neonatal development during pregnancy.http://ijbms.mums.ac.ir/article_10365_da69f2e18f7ee4c7f21f33569bea2a26.pdfFluoxetineHeartKidneyLungSSRIs |
| spellingShingle | Razieh Taghizadeh Ghvamabadi Zahra Taghipour Mahsa Hasanipoor Marzieh Khademi Mehdi Shariati Effect of maternal fluoxetine exposure on lung, heart and kidney development in rat neonates Iranian Journal of Basic Medical Sciences Fluoxetine Heart Kidney Lung SSRIs |
| title | Effect of maternal fluoxetine exposure on lung, heart and kidney development in rat neonates |
| title_full | Effect of maternal fluoxetine exposure on lung, heart and kidney development in rat neonates |
| title_fullStr | Effect of maternal fluoxetine exposure on lung, heart and kidney development in rat neonates |
| title_full_unstemmed | Effect of maternal fluoxetine exposure on lung, heart and kidney development in rat neonates |
| title_short | Effect of maternal fluoxetine exposure on lung, heart and kidney development in rat neonates |
| title_sort | effect of maternal fluoxetine exposure on lung heart and kidney development in rat neonates |
| topic | Fluoxetine Heart Kidney Lung SSRIs |
| url | http://ijbms.mums.ac.ir/article_10365_da69f2e18f7ee4c7f21f33569bea2a26.pdf |
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