Correlation between 25-hydroxy-vitamin D and Parkinson's disease
Background: Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25-hydroxyvitamin D (25(OH)D) concentrations than controls. Other studies have not yet tested whether research findings from other regions are generalizable to Chinese populations. In this...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123000167 |
| _version_ | 1797341465561530368 |
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| author | Ming Xia Qingjiu Zhou |
| author_facet | Ming Xia Qingjiu Zhou |
| author_sort | Ming Xia |
| collection | DOAJ |
| description | Background: Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25-hydroxyvitamin D (25(OH)D) concentrations than controls. Other studies have not yet tested whether research findings from other regions are generalizable to Chinese populations. In this case-control study, we examined the correlation between 25-hydroxyvitamin D and Parkinson's disease. Methods: We established an association between 25-hydroxyvitamin D deficiency and PD in a case-control study of 100 PD patients and 100 control subjects free of neurological disease at the First Affiliated Hospital of Xinjiang Medical University. Results: Total 25-hydroxyvitamin D levels were deficient in 21 % of patients with PD compared with 4 % of controls. In univariate analyses, plasma levels of 25-hydroxyvitamin D were associated with PD (p < 0.001). In multivariate analyses, vitamin D deficiency (25(OH)D < 20 ng/mL) was significantly associated with PD (p = 0.008, Odds Ratio =17.13, 95 % CI= 2.082–141.075). Individuals with 25(OH)D levels in the lowest quartile had the highest prevalence of PD (p = 0.026, OR=11.786, 95 % CI =1.342–103.51 compared to individuals with values in the highest quartile). Conclusions: Our study reveals an association between 25-hydroxyvitamin D and PD. Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls. High-risk PD patients with vitamin D deficiency who have not yet developed exercise impairment should undergo vitamin D measurement and any necessary treatment as soon as possible. Limitations of the study: the study needs further assessment of populations with low vitamin D levels in other regions of China; further assessment of the effect of different sources of vitamin D on PD; further study of longitudinal cohorts at different time points. |
| first_indexed | 2024-03-08T10:18:32Z |
| format | Article |
| id | doaj.art-3381bb126491456abd45f11ccf952cb6 |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-08T10:18:32Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-3381bb126491456abd45f11ccf952cb62024-01-28T04:21:55ZengElsevierIBRO Neuroscience Reports2667-24212024-06-0116162167Correlation between 25-hydroxy-vitamin D and Parkinson's diseaseMing Xia0Qingjiu Zhou1Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, ChinaCorrespondence to: Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, China.; Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, ChinaBackground: Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25-hydroxyvitamin D (25(OH)D) concentrations than controls. Other studies have not yet tested whether research findings from other regions are generalizable to Chinese populations. In this case-control study, we examined the correlation between 25-hydroxyvitamin D and Parkinson's disease. Methods: We established an association between 25-hydroxyvitamin D deficiency and PD in a case-control study of 100 PD patients and 100 control subjects free of neurological disease at the First Affiliated Hospital of Xinjiang Medical University. Results: Total 25-hydroxyvitamin D levels were deficient in 21 % of patients with PD compared with 4 % of controls. In univariate analyses, plasma levels of 25-hydroxyvitamin D were associated with PD (p < 0.001). In multivariate analyses, vitamin D deficiency (25(OH)D < 20 ng/mL) was significantly associated with PD (p = 0.008, Odds Ratio =17.13, 95 % CI= 2.082–141.075). Individuals with 25(OH)D levels in the lowest quartile had the highest prevalence of PD (p = 0.026, OR=11.786, 95 % CI =1.342–103.51 compared to individuals with values in the highest quartile). Conclusions: Our study reveals an association between 25-hydroxyvitamin D and PD. Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls. High-risk PD patients with vitamin D deficiency who have not yet developed exercise impairment should undergo vitamin D measurement and any necessary treatment as soon as possible. Limitations of the study: the study needs further assessment of populations with low vitamin D levels in other regions of China; further assessment of the effect of different sources of vitamin D on PD; further study of longitudinal cohorts at different time points.http://www.sciencedirect.com/science/article/pii/S2667242123000167Vitamin DParkinson’s disease25-hydroxy vitamin DSunshineHoehn and Yahr stage |
| spellingShingle | Ming Xia Qingjiu Zhou Correlation between 25-hydroxy-vitamin D and Parkinson's disease IBRO Neuroscience Reports Vitamin D Parkinson’s disease 25-hydroxy vitamin D Sunshine Hoehn and Yahr stage |
| title | Correlation between 25-hydroxy-vitamin D and Parkinson's disease |
| title_full | Correlation between 25-hydroxy-vitamin D and Parkinson's disease |
| title_fullStr | Correlation between 25-hydroxy-vitamin D and Parkinson's disease |
| title_full_unstemmed | Correlation between 25-hydroxy-vitamin D and Parkinson's disease |
| title_short | Correlation between 25-hydroxy-vitamin D and Parkinson's disease |
| title_sort | correlation between 25 hydroxy vitamin d and parkinson s disease |
| topic | Vitamin D Parkinson’s disease 25-hydroxy vitamin D Sunshine Hoehn and Yahr stage |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123000167 |
| work_keys_str_mv | AT mingxia correlationbetween25hydroxyvitamindandparkinsonsdisease AT qingjiuzhou correlationbetween25hydroxyvitamindandparkinsonsdisease |