Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease
Aim. Assessment of the irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth syndrome (SIBO) interlinkage.Key points. SIBO may represent a "peripheral" mechanism of IBS, aside to nonspecific inflammation, increased epithelial permeability and local immune system activati...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2021-04-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/522 |
| _version_ | 1797245178035044352 |
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| author | K. V. Ivashkin V. R. Grechishnikova M. S. Reshetova V. T. Ivashkin |
| author_facet | K. V. Ivashkin V. R. Grechishnikova M. S. Reshetova V. T. Ivashkin |
| author_sort | K. V. Ivashkin |
| collection | DOAJ |
| description | Aim. Assessment of the irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth syndrome (SIBO) interlinkage.Key points. SIBO may represent a "peripheral" mechanism of IBS, aside to nonspecific inflammation, increased epithelial permeability and local immune system activation. In various assays, the SIBO rate in IBS patients was 4-46% vs. 0-13% in an intact cohort. A limited diagnosability of SIBO obscures the SIBO-IBS causal interplay. Impaired motility in IBS may predispose to the SIBO development. Proinflammatory cytokines and mediators in SIBO, in turn, provoke visceral hypersensitivity and intense motility, the key IBS factors. Both conditions relate to qualitative and quantitative changes in microbiota, which warrants the application of probiotic Lactobacillus and Bifidobacterium strains.Conclusion. Further research into the SIBO-IBS interface is required for developing optimal probiotic-based therapies. |
| first_indexed | 2024-03-08T09:20:46Z |
| format | Article |
| id | doaj.art-3383e5e21f33490abd57f8191b89fa87 |
| institution | Directory Open Access Journal |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| last_indexed | 2024-04-24T19:22:46Z |
| publishDate | 2021-04-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj.art-3383e5e21f33490abd57f8191b89fa872024-03-25T16:53:09ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732021-04-01311546310.22416/1382-4376-2021-31-1-54-63411Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional DiseaseK. V. Ivashkin0V. R. Grechishnikova1M. S. Reshetova2V. T. Ivashkin3Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Aim. Assessment of the irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth syndrome (SIBO) interlinkage.Key points. SIBO may represent a "peripheral" mechanism of IBS, aside to nonspecific inflammation, increased epithelial permeability and local immune system activation. In various assays, the SIBO rate in IBS patients was 4-46% vs. 0-13% in an intact cohort. A limited diagnosability of SIBO obscures the SIBO-IBS causal interplay. Impaired motility in IBS may predispose to the SIBO development. Proinflammatory cytokines and mediators in SIBO, in turn, provoke visceral hypersensitivity and intense motility, the key IBS factors. Both conditions relate to qualitative and quantitative changes in microbiota, which warrants the application of probiotic Lactobacillus and Bifidobacterium strains.Conclusion. Further research into the SIBO-IBS interface is required for developing optimal probiotic-based therapies.https://www.gastro-j.ru/jour/article/view/522small intestinal bacterial overgrowthirritable bowel syndromegut microbiotaprobioticslactobacillusbifidobacterium |
| spellingShingle | K. V. Ivashkin V. R. Grechishnikova M. S. Reshetova V. T. Ivashkin Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии small intestinal bacterial overgrowth irritable bowel syndrome gut microbiota probiotics lactobacillus bifidobacterium |
| title | Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease |
| title_full | Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease |
| title_fullStr | Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease |
| title_full_unstemmed | Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease |
| title_short | Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease |
| title_sort | irritable bowel and bacterial overgrowth syndromes a bacterial link hypothesis of functional disease |
| topic | small intestinal bacterial overgrowth irritable bowel syndrome gut microbiota probiotics lactobacillus bifidobacterium |
| url | https://www.gastro-j.ru/jour/article/view/522 |
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