Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study
Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/10/3196 |
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| author | Núria Voltas Josefa Canals Carmen Hernández-Martínez Núria Serrat Josep Basora Victoria Arija |
| author_facet | Núria Voltas Josefa Canals Carmen Hernández-Martínez Núria Serrat Josep Basora Victoria Arija |
| author_sort | Núria Voltas |
| collection | DOAJ |
| description | Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother–infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (<30 nmol/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (<20 nmol/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment. |
| first_indexed | 2024-03-10T15:30:19Z |
| format | Article |
| id | doaj.art-338425f629e948b69ee5058af39b10f3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:30:19Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-338425f629e948b69ee5058af39b10f32023-11-20T17:41:16ZengMDPI AGNutrients2072-66432020-10-011210319610.3390/nu12103196Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES StudyNúria Voltas0Josefa Canals1Carmen Hernández-Martínez2Núria Serrat3Josep Basora4Victoria Arija5Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i Virgili, 43204 Reus, SpainResearch Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i Virgili, 43204 Reus, SpainResearch Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i Virgili, 43204 Reus, SpainLaboratory ICS Tarragona, University Hospital of Tarragona Joan XXIII, Catalan Institute of Health (ICS), 43005 Tarragona, SpainCollaborative Research Group on Lifestyles, Nutrition and Smoking (CENIT), Jordi Gol Primary Care Research Institute (IDIAPJGol), Camí de Riudoms 53-55, 43202 Reus, SpainResearch Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i Virgili, 43204 Reus, SpainVitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother–infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (<30 nmol/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (<20 nmol/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment.https://www.mdpi.com/2072-6643/12/10/3196vitamin Dpregnancyprenatal nutritionneurodevelopmentinfant |
| spellingShingle | Núria Voltas Josefa Canals Carmen Hernández-Martínez Núria Serrat Josep Basora Victoria Arija Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study Nutrients vitamin D pregnancy prenatal nutrition neurodevelopment infant |
| title | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
| title_full | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
| title_fullStr | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
| title_full_unstemmed | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
| title_short | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
| title_sort | effect of vitamin d status during pregnancy on infant neurodevelopment the eclipses study |
| topic | vitamin D pregnancy prenatal nutrition neurodevelopment infant |
| url | https://www.mdpi.com/2072-6643/12/10/3196 |
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