Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot study
Background: Chemical treatments for the modulation of host response are applied along with mechanical modalities as adjunctive to periodontal treatment. The objective of this pilot study was to investigate the effects of locally-delivered alendronate sodium gel in adjunction to scaling and root plan...
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| Format: | Article |
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Kashan University of Medical Sciences and Health Services
2017-04-01
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| Series: | Fiyz̤ |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-3281-en.html |
| _version_ | 1831521703294926848 |
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| author | Farin Kiany Hashem Montaseri Sadaf Adibi Masoud Golshah Saba Golshah |
| author_facet | Farin Kiany Hashem Montaseri Sadaf Adibi Masoud Golshah Saba Golshah |
| author_sort | Farin Kiany |
| collection | DOAJ |
| description | Background: Chemical treatments for the modulation of host response are applied along with mechanical modalities as adjunctive to periodontal treatment. The objective of this pilot study was to investigate the effects of locally-delivered alendronate sodium gel in adjunction to scaling and root planning on periodontal indices and bone formation within vertical defects of smokers with chronic periodontitis.
Methods and Materials: In this study vertical defects (n=8) with depth>5 mm have been investigated. After performing the phase I of periodontal treatment, alendronate sodium gel (1%) was applied into the periodontal pockets. The whole procedure was repeated after 4 weeks. Periodontal indices (plaque and bleeding), probing depth, gingival recession, and radiographic parameter (depth of bony defect) were measured at the beginning and following 6 months.
Results: Compared to pre-treatment, the probing depth, radiographic depth of bony defect and bleeding and plaque indices were significantly reduced by local application of alendronate sodium gel (P=0.026; P=0.012 and P=0.007 respectively). Gingival recession showed significant increase (P=0.011).
Conclusion: Local alendronate sodium gel (1%) plays an important role in the improvement process of periodontal indices and bone formation within vertical bony defects of smoker patients with chronic periodontitis. |
| first_indexed | 2024-12-14T01:11:48Z |
| format | Article |
| id | doaj.art-3385c217a084427d8b6a7db6f0635bdd |
| institution | Directory Open Access Journal |
| issn | 1029-7855 2008-9821 |
| language | fas |
| last_indexed | 2024-12-14T01:11:48Z |
| publishDate | 2017-04-01 |
| publisher | Kashan University of Medical Sciences and Health Services |
| record_format | Article |
| series | Fiyz̤ |
| spelling | doaj.art-3385c217a084427d8b6a7db6f0635bdd2022-12-21T23:22:42ZfasKashan University of Medical Sciences and Health ServicesFiyz̤1029-78552008-98212017-04-012114250Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot studyFarin Kiany 0 Hashem Montaseri1 Sadaf Adibi2Masoud Golshah 3 Saba Golshah 4Department of Periodontology, Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I. R. Iran.Department of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. Department of Periodontology, School of Dentistry, Kashan University of Medical Sciences, Kashan, I. R. Iran. Dental Student, Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. Background: Chemical treatments for the modulation of host response are applied along with mechanical modalities as adjunctive to periodontal treatment. The objective of this pilot study was to investigate the effects of locally-delivered alendronate sodium gel in adjunction to scaling and root planning on periodontal indices and bone formation within vertical defects of smokers with chronic periodontitis. Methods and Materials: In this study vertical defects (n=8) with depth>5 mm have been investigated. After performing the phase I of periodontal treatment, alendronate sodium gel (1%) was applied into the periodontal pockets. The whole procedure was repeated after 4 weeks. Periodontal indices (plaque and bleeding), probing depth, gingival recession, and radiographic parameter (depth of bony defect) were measured at the beginning and following 6 months. Results: Compared to pre-treatment, the probing depth, radiographic depth of bony defect and bleeding and plaque indices were significantly reduced by local application of alendronate sodium gel (P=0.026; P=0.012 and P=0.007 respectively). Gingival recession showed significant increase (P=0.011). Conclusion: Local alendronate sodium gel (1%) plays an important role in the improvement process of periodontal indices and bone formation within vertical bony defects of smoker patients with chronic periodontitis.http://feyz.kaums.ac.ir/article-1-3281-en.htmlChronic periodontitisAlendronatePeriodontal indexAlveolar bone resorptionCigarette smoking |
| spellingShingle | Farin Kiany Hashem Montaseri Sadaf Adibi Masoud Golshah Saba Golshah Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot study Fiyz̤ Chronic periodontitis Alendronate Periodontal index Alveolar bone resorption Cigarette smoking |
| title | Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot study |
| title_full | Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot study |
| title_fullStr | Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot study |
| title_full_unstemmed | Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot study |
| title_short | Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot study |
| title_sort | effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis a pilot study |
| topic | Chronic periodontitis Alendronate Periodontal index Alveolar bone resorption Cigarette smoking |
| url | http://feyz.kaums.ac.ir/article-1-3281-en.html |
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