C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in Schizophrenia and Bipolar disorder: An association study in Iranian population
"n Objective: The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T is suspected to be a risk factor for psychiatric disorders, but it remains inconclusive whether the MTHFR polymorphism C677T is imputed to vulnerability to schizophrenia and bipolar disorder. "n "nMe...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2011-01-01
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| Series: | Iranian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/18125.pdf&manuscript_id=18125 |
| _version_ | 1818757755672985600 |
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| author | Bagher Larijani Jamal Shams Alireza Ghodsipour Seyed Vahid Shariat Arash Hossein Nezhad Seyed Masoud Arzaghi |
| author_facet | Bagher Larijani Jamal Shams Alireza Ghodsipour Seyed Vahid Shariat Arash Hossein Nezhad Seyed Masoud Arzaghi |
| author_sort | Bagher Larijani |
| collection | DOAJ |
| description | "n Objective: The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T is suspected to be a risk factor for psychiatric disorders, but it remains inconclusive whether the MTHFR polymorphism C677T is imputed to vulnerability to schizophrenia and bipolar disorder. "n "nMethod: We prompted impetus to appraise this polymorphism in an Iranian population. Therefore, 90 patients with bipolar disorder type I (BID) , 66 patients with schizophrenia diagnosed according to DSM-IV criteria, and 94 unrelated controls with no history of psychiatric disorders were recruited for this study. Genotype distribution and allelic frequencies of C677T polymorphism were investigated. "nResults:We found no robust differences between patients with BID and schizophrenia with control participants either for allele frequencies or genotype distribution of MTHFR C677T polymorphism. However, a trend toward an increased risk for T allele was observed in the BID patients [with odds ratio (OR) of 1.28(CI 95%: 0.8-1.31), p>0.05]. "nConclusion:However, the present and some previous studies failed to elucidate possible interaction between MTHFR C677T polymorphism and vulnerability to schizophrenia and bipolar disorder; still some associations have been revealed in performed meta-analyses that warrant further studies. |
| first_indexed | 2024-12-18T06:15:59Z |
| format | Article |
| id | doaj.art-3385cb2ba2614cec8852917662c89997 |
| institution | Directory Open Access Journal |
| issn | 1735-4587 2008-2215 |
| language | English |
| last_indexed | 2024-12-18T06:15:59Z |
| publishDate | 2011-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Psychiatry |
| spelling | doaj.art-3385cb2ba2614cec8852917662c899972022-12-21T21:18:15ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152011-01-016116C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in Schizophrenia and Bipolar disorder: An association study in Iranian populationBagher LarijaniJamal ShamsAlireza GhodsipourSeyed Vahid ShariatArash Hossein NezhadSeyed Masoud Arzaghi"n Objective: The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T is suspected to be a risk factor for psychiatric disorders, but it remains inconclusive whether the MTHFR polymorphism C677T is imputed to vulnerability to schizophrenia and bipolar disorder. "n "nMethod: We prompted impetus to appraise this polymorphism in an Iranian population. Therefore, 90 patients with bipolar disorder type I (BID) , 66 patients with schizophrenia diagnosed according to DSM-IV criteria, and 94 unrelated controls with no history of psychiatric disorders were recruited for this study. Genotype distribution and allelic frequencies of C677T polymorphism were investigated. "nResults:We found no robust differences between patients with BID and schizophrenia with control participants either for allele frequencies or genotype distribution of MTHFR C677T polymorphism. However, a trend toward an increased risk for T allele was observed in the BID patients [with odds ratio (OR) of 1.28(CI 95%: 0.8-1.31), p>0.05]. "nConclusion:However, the present and some previous studies failed to elucidate possible interaction between MTHFR C677T polymorphism and vulnerability to schizophrenia and bipolar disorder; still some associations have been revealed in performed meta-analyses that warrant further studies.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/18125.pdf&manuscript_id=18125 PolymorphismSchizophreniaBipolar disordeMethylenetetrahydrofolate reductase |
| spellingShingle | Bagher Larijani Jamal Shams Alireza Ghodsipour Seyed Vahid Shariat Arash Hossein Nezhad Seyed Masoud Arzaghi C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in Schizophrenia and Bipolar disorder: An association study in Iranian population Iranian Journal of Psychiatry Polymorphism Schizophrenia Bipolar disorde Methylenetetrahydrofolate reductase |
| title | C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in Schizophrenia and Bipolar disorder: An association study in Iranian population |
| title_full | C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in Schizophrenia and Bipolar disorder: An association study in Iranian population |
| title_fullStr | C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in Schizophrenia and Bipolar disorder: An association study in Iranian population |
| title_full_unstemmed | C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in Schizophrenia and Bipolar disorder: An association study in Iranian population |
| title_short | C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in Schizophrenia and Bipolar disorder: An association study in Iranian population |
| title_sort | c677t methylenetetrahydrofolate reductase mthfr gene polymorphism in schizophrenia and bipolar disorder an association study in iranian population |
| topic | Polymorphism Schizophrenia Bipolar disorde Methylenetetrahydrofolate reductase |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/18125.pdf&manuscript_id=18125 |
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