Intravitreal bevacizumab for treatment of central serous chorioretinopathy
Purpose: To compare the outcomes of treatment with intravitreal bevacizumab (IVB) versus observation in central serous chorioretinopathy (CSCR). Methods: In a retrospective comparative study, records of 45 patients with CSCR were reviewed. Twenty-two patients received IVB (1.25 mg/0.05 ml) while 23...
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| Format: | Article |
| Language: | English |
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Knowledge E
2016-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | http://www.jovr.org/article.asp?issn=2008-322X;year=2016;volume=11;issue=1;spage=61;epage=65;aulast=Ünlü |
| _version_ | 1811323992000167936 |
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| author | Cihan Ünlü Gurkan Erdogan Tugba Aydogan Betul Ilkay Sezgin Akcay Esra Kardes Gulunay Akcali Kiray Tahir Kansu Bozkurt |
| author_facet | Cihan Ünlü Gurkan Erdogan Tugba Aydogan Betul Ilkay Sezgin Akcay Esra Kardes Gulunay Akcali Kiray Tahir Kansu Bozkurt |
| author_sort | Cihan Ünlü |
| collection | DOAJ |
| description | Purpose: To compare the outcomes of treatment with intravitreal bevacizumab (IVB) versus observation in central serous chorioretinopathy (CSCR).
Methods: In a retrospective comparative study, records of 45 patients with CSCR were reviewed. Twenty-two patients received IVB (1.25 mg/0.05 ml) while 23 subjects were observed. All subjects underwent measurement of best corrected visual acuity (BCVA) and intraocular pressure (IOP), dilated fundus examination and optical coherence tomography (OCT) imaging at baseline and follow up visits. Outcome measures included central macular thickness (CMT) and BCVA in logarithm of minimum angle of resolution (logMAR) notations.
Results: Mean age was 44.1 ± 9.3 (range: 24 to 64) years and mean follow-up period was 10.4 ± 11.2 (range: 3 to 43; median: 6) months. All patients demonstrated resolution of neurosensory detachment and improvement in visual acuity. At final visit, there was no significant difference in mean CMT between the IVB and observation groups (275 vs 284 μm, P> 0.05). Mean baseline logMAR visual acuity was 0.38 ± 0.24 in the IVB group which improved to 0.24 ± 0.31 at final follow-up (P = 0.011); mean baseline logMAR visual acuity was 0.42 ± 0.28 in the observation group and improved to 0.12 ± 0.18 (P = 0.001). Visual improvement was more marked in the observation group (0.30 vs 0.14 logMAR, P< 0.05) and mean final visual acuity was also significantly better (P = 0.05).
Conclusion: There was no significant difference between IVB injection and observation in terms of anatomical outcomes of treatment for CSCR. In terms of visual outcomes, observation was superior to IVB injection. |
| first_indexed | 2024-04-13T14:05:16Z |
| format | Article |
| id | doaj.art-338718cb1fe7466b959d3e48d20811e6 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-13T14:05:16Z |
| publishDate | 2016-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-338718cb1fe7466b959d3e48d20811e62022-12-22T02:43:55ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2016-01-01111616510.4103/2008-322X.180700Intravitreal bevacizumab for treatment of central serous chorioretinopathyCihan ÜnlüGurkan ErdoganTugba AydoganBetul Ilkay Sezgin AkcayEsra KardesGulunay Akcali KirayTahir Kansu BozkurtPurpose: To compare the outcomes of treatment with intravitreal bevacizumab (IVB) versus observation in central serous chorioretinopathy (CSCR). Methods: In a retrospective comparative study, records of 45 patients with CSCR were reviewed. Twenty-two patients received IVB (1.25 mg/0.05 ml) while 23 subjects were observed. All subjects underwent measurement of best corrected visual acuity (BCVA) and intraocular pressure (IOP), dilated fundus examination and optical coherence tomography (OCT) imaging at baseline and follow up visits. Outcome measures included central macular thickness (CMT) and BCVA in logarithm of minimum angle of resolution (logMAR) notations. Results: Mean age was 44.1 ± 9.3 (range: 24 to 64) years and mean follow-up period was 10.4 ± 11.2 (range: 3 to 43; median: 6) months. All patients demonstrated resolution of neurosensory detachment and improvement in visual acuity. At final visit, there was no significant difference in mean CMT between the IVB and observation groups (275 vs 284 μm, P> 0.05). Mean baseline logMAR visual acuity was 0.38 ± 0.24 in the IVB group which improved to 0.24 ± 0.31 at final follow-up (P = 0.011); mean baseline logMAR visual acuity was 0.42 ± 0.28 in the observation group and improved to 0.12 ± 0.18 (P = 0.001). Visual improvement was more marked in the observation group (0.30 vs 0.14 logMAR, P< 0.05) and mean final visual acuity was also significantly better (P = 0.05). Conclusion: There was no significant difference between IVB injection and observation in terms of anatomical outcomes of treatment for CSCR. In terms of visual outcomes, observation was superior to IVB injection.http://www.jovr.org/article.asp?issn=2008-322X;year=2016;volume=11;issue=1;spage=61;epage=65;aulast=ÜnlüIntravitreal Bevacizumab (Avastin); Central Serous Chorioretinopathy; Macular Thickness; Observation |
| spellingShingle | Cihan Ünlü Gurkan Erdogan Tugba Aydogan Betul Ilkay Sezgin Akcay Esra Kardes Gulunay Akcali Kiray Tahir Kansu Bozkurt Intravitreal bevacizumab for treatment of central serous chorioretinopathy Journal of Ophthalmic & Vision Research Intravitreal Bevacizumab (Avastin); Central Serous Chorioretinopathy; Macular Thickness; Observation |
| title | Intravitreal bevacizumab for treatment of central serous chorioretinopathy |
| title_full | Intravitreal bevacizumab for treatment of central serous chorioretinopathy |
| title_fullStr | Intravitreal bevacizumab for treatment of central serous chorioretinopathy |
| title_full_unstemmed | Intravitreal bevacizumab for treatment of central serous chorioretinopathy |
| title_short | Intravitreal bevacizumab for treatment of central serous chorioretinopathy |
| title_sort | intravitreal bevacizumab for treatment of central serous chorioretinopathy |
| topic | Intravitreal Bevacizumab (Avastin); Central Serous Chorioretinopathy; Macular Thickness; Observation |
| url | http://www.jovr.org/article.asp?issn=2008-322X;year=2016;volume=11;issue=1;spage=61;epage=65;aulast=Ünlü |
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