Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering
We review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-09-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2077-0375/5/3/454 |
| _version_ | 1797706309778276352 |
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| author | Norbert Kučerka Frederick A. Heberle Jianjun Pan John Katsaras |
| author_facet | Norbert Kučerka Frederick A. Heberle Jianjun Pan John Katsaras |
| author_sort | Norbert Kučerka |
| collection | DOAJ |
| description | We review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by the sometimes conflicting results found in the literature, even in the case of the most studied lipid bilayers. Increasingly, accurate and detailed structural models require more experimental data, such as those from contrast varied neutron scattering and X-ray scattering experiments that are jointly refined with molecular dynamics simulations. This experimental and computational approach produces robust bilayer structural parameters that enable insights, for example, into the interplay between collective membrane properties and its components (e.g., hydrocarbon chain length and unsaturation, and lipid headgroup composition). From model studies such as these, one is better able to appreciate how a real biological membrane can be tuned by balancing the contributions from the lipid’s different moieties (e.g., acyl chains, headgroups, backbones, etc.). |
| first_indexed | 2024-03-12T05:49:20Z |
| format | Article |
| id | doaj.art-33885050cae544539051779cc871edfc |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-12T05:49:20Z |
| publishDate | 2015-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-33885050cae544539051779cc871edfc2023-09-03T05:18:12ZengMDPI AGMembranes2077-03752015-09-015345447210.3390/membranes5030454membranes5030454Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray ScatteringNorbert Kučerka0Frederick A. Heberle1Jianjun Pan2John Katsaras3Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, 141980 Dubna—Moscow Region, RussiaBiology & Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USADepartment of Physics, University of South Florida, Tampa, FL 33620, USABiology & Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USAWe review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by the sometimes conflicting results found in the literature, even in the case of the most studied lipid bilayers. Increasingly, accurate and detailed structural models require more experimental data, such as those from contrast varied neutron scattering and X-ray scattering experiments that are jointly refined with molecular dynamics simulations. This experimental and computational approach produces robust bilayer structural parameters that enable insights, for example, into the interplay between collective membrane properties and its components (e.g., hydrocarbon chain length and unsaturation, and lipid headgroup composition). From model studies such as these, one is better able to appreciate how a real biological membrane can be tuned by balancing the contributions from the lipid’s different moieties (e.g., acyl chains, headgroups, backbones, etc.).http://www.mdpi.com/2077-0375/5/3/454lipidomebilayerstructureX-ray scatteringneutron scatteringlipid area |
| spellingShingle | Norbert Kučerka Frederick A. Heberle Jianjun Pan John Katsaras Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering Membranes lipidome bilayer structure X-ray scattering neutron scattering lipid area |
| title | Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_full | Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_fullStr | Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_full_unstemmed | Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_short | Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_sort | structural significance of lipid diversity as studied by small angle neutron and x ray scattering |
| topic | lipidome bilayer structure X-ray scattering neutron scattering lipid area |
| url | http://www.mdpi.com/2077-0375/5/3/454 |
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