Diffusion-Weighted-Imaging Negative Stroke Syndromes
Objective: Normal diffusion-weighted imaging (DWI) during the acute symptomatic phase of an ischemic stroke is a rare, but a well-known phenomenon. The exact rate and the clinical correlates of this phenomenon are not satisfactorily elucidated. Materials and Methods: Consecutive patients who were h...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-06-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-67878&look4= |
| _version_ | 1797919291526348800 |
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| author | Mehmet Yasir Pektezel Ethem Murat Arsava Rahşan Göçmen Kader Karlı Oğuz Mehmet Akif Topçuoğlu |
| author_facet | Mehmet Yasir Pektezel Ethem Murat Arsava Rahşan Göçmen Kader Karlı Oğuz Mehmet Akif Topçuoğlu |
| author_sort | Mehmet Yasir Pektezel |
| collection | DOAJ |
| description | Objective: Normal diffusion-weighted imaging (DWI) during the acute symptomatic phase of an ischemic stroke is a rare, but a well-known phenomenon. The exact rate and the clinical correlates of this phenomenon are not satisfactorily elucidated.
Materials and Methods: Consecutive patients who were hospitalized with the diagnosis of acute ischemic stroke in the last 10 years and who had DWI (with a bmax of 1000 s/mm2) in the first 12 hours were included. A systematic review of published DWI-negative stroke cases and case series was performed. Alternate diagnoses including transient ischemic attack or stroke mimics such as seizure, migraine, functional disorders, and post-stroke recrudescence were excluded.
Results: The diagnosis of DWI-negative stroke syndrome was made in 20 (1.3%) of 1.506 patients hospitalized in Hacettepe Hospitals. A literature search disclosed another 535 (6.6%) DWI-negative strokes out of 8.101 cases. A total of 115, identified in case reports and cohort (n=19) articles, were combined with our cases to delineate further characteristics of DWI-negative clinical stroke syndromes. DWI-negative syndromes (n=135) were “brainstem mini-strokes” (31.1%), “cortical small embolic infarcts” (5.2%), “pure penumbral stroke” (normal DWI with magnetic resonance perfusion deficit) (34.8%); “aborted stroke” (early and fully recanalized stroke, only diagnosable in patients with documented acute vessel occlusion) (5.2%); and “miscellaneous” (23.7%). Corresponding clinical stroke syndromes include partial hemispheric deficits (36.1%), focal cortical syndromes (4.3%), caudal brainstem syndromes (9.3%), acute isolated vertigo (9.3%), vertigo-plus syndromes (10.1%), ocular syndromes (7.4%), movement disorders (1.9%), typical lacunar syndromes (11.1%), and atypical lacunar syndromes such as ataxia ± dysatrhria (9.3%).
Conclusion: In clinical practice of acute ischemic stroke, early DWI imaging can be negative in various clinical syndromes. Imaging repetition is necessary for the diagnosis and management plan of these patients. |
| first_indexed | 2024-04-10T13:43:18Z |
| format | Article |
| id | doaj.art-33888b0f26e643748c46e2c704460718 |
| institution | Directory Open Access Journal |
| issn | 1309-2545 |
| language | English |
| last_indexed | 2024-04-10T13:43:18Z |
| publishDate | 2021-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-33888b0f26e643748c46e2c7044607182023-02-15T16:11:05ZengGalenos YayineviTürk Nöroloji Dergisi1309-25452021-06-0127215115710.4274/tnd.2021.67878Diffusion-Weighted-Imaging Negative Stroke SyndromesMehmet Yasir Pektezel0https://orcid.org/0000-0003-1619-2759Ethem Murat Arsava1https://orcid.org/0000-0002-6527-4139Rahşan Göçmen2https://orcid.org/0000-0002-0223-9336Kader Karlı Oğuz3https://orcid.org/0000-0002-3385-4665Mehmet Akif Topçuoğlu4https://orcid.org/0000-0002-7267-1431Hacettepe University Faculty of Medicine, Department of Neurology, Neurology Intensive Care Unit, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Neurology, Neurology Intensive Care Unit, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Radiology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Radiology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Neurology, Neurology Intensive Care Unit, Ankara, TurkeyObjective: Normal diffusion-weighted imaging (DWI) during the acute symptomatic phase of an ischemic stroke is a rare, but a well-known phenomenon. The exact rate and the clinical correlates of this phenomenon are not satisfactorily elucidated. Materials and Methods: Consecutive patients who were hospitalized with the diagnosis of acute ischemic stroke in the last 10 years and who had DWI (with a bmax of 1000 s/mm2) in the first 12 hours were included. A systematic review of published DWI-negative stroke cases and case series was performed. Alternate diagnoses including transient ischemic attack or stroke mimics such as seizure, migraine, functional disorders, and post-stroke recrudescence were excluded. Results: The diagnosis of DWI-negative stroke syndrome was made in 20 (1.3%) of 1.506 patients hospitalized in Hacettepe Hospitals. A literature search disclosed another 535 (6.6%) DWI-negative strokes out of 8.101 cases. A total of 115, identified in case reports and cohort (n=19) articles, were combined with our cases to delineate further characteristics of DWI-negative clinical stroke syndromes. DWI-negative syndromes (n=135) were “brainstem mini-strokes” (31.1%), “cortical small embolic infarcts” (5.2%), “pure penumbral stroke” (normal DWI with magnetic resonance perfusion deficit) (34.8%); “aborted stroke” (early and fully recanalized stroke, only diagnosable in patients with documented acute vessel occlusion) (5.2%); and “miscellaneous” (23.7%). Corresponding clinical stroke syndromes include partial hemispheric deficits (36.1%), focal cortical syndromes (4.3%), caudal brainstem syndromes (9.3%), acute isolated vertigo (9.3%), vertigo-plus syndromes (10.1%), ocular syndromes (7.4%), movement disorders (1.9%), typical lacunar syndromes (11.1%), and atypical lacunar syndromes such as ataxia ± dysatrhria (9.3%). Conclusion: In clinical practice of acute ischemic stroke, early DWI imaging can be negative in various clinical syndromes. Imaging repetition is necessary for the diagnosis and management plan of these patients.https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-67878&look4=diffusion-weighted imagingneurologic examinationneurologistmedical history takingstrokeimitator |
| spellingShingle | Mehmet Yasir Pektezel Ethem Murat Arsava Rahşan Göçmen Kader Karlı Oğuz Mehmet Akif Topçuoğlu Diffusion-Weighted-Imaging Negative Stroke Syndromes Türk Nöroloji Dergisi diffusion-weighted imaging neurologic examination neurologist medical history taking stroke imitator |
| title | Diffusion-Weighted-Imaging Negative Stroke Syndromes |
| title_full | Diffusion-Weighted-Imaging Negative Stroke Syndromes |
| title_fullStr | Diffusion-Weighted-Imaging Negative Stroke Syndromes |
| title_full_unstemmed | Diffusion-Weighted-Imaging Negative Stroke Syndromes |
| title_short | Diffusion-Weighted-Imaging Negative Stroke Syndromes |
| title_sort | diffusion weighted imaging negative stroke syndromes |
| topic | diffusion-weighted imaging neurologic examination neurologist medical history taking stroke imitator |
| url | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-67878&look4= |
| work_keys_str_mv | AT mehmetyasirpektezel diffusionweightedimagingnegativestrokesyndromes AT ethemmuratarsava diffusionweightedimagingnegativestrokesyndromes AT rahsangocmen diffusionweightedimagingnegativestrokesyndromes AT kaderkarlıoguz diffusionweightedimagingnegativestrokesyndromes AT mehmetakiftopcuoglu diffusionweightedimagingnegativestrokesyndromes |