Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort Study
Liping Shen,1,* Linping Chen,1,* Hongbo Chi,1 Lifei Luo,1 Jinsu Ruan,1 Xinzhuan Zhao,1 Yi Jiang,1 Tao-Hsin Tung,2 Hongguo Zhu,1 Kai Zhou,1 Bo Shen,1 Jiaqin Xu1 1Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-03-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/parameters-and-morphological-changes-of-erythrocytes-and-platelets-of--peer-reviewed-fulltext-article-IDR |
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| author | Shen L Chen L Chi H Luo L Ruan J Zhao X Jiang Y Tung TH Zhu H Zhou K Shen B Xu J |
| author_facet | Shen L Chen L Chi H Luo L Ruan J Zhao X Jiang Y Tung TH Zhu H Zhou K Shen B Xu J |
| author_sort | Shen L |
| collection | DOAJ |
| description | Liping Shen,1,* Linping Chen,1,* Hongbo Chi,1 Lifei Luo,1 Jinsu Ruan,1 Xinzhuan Zhao,1 Yi Jiang,1 Tao-Hsin Tung,2 Hongguo Zhu,1 Kai Zhou,1 Bo Shen,1 Jiaqin Xu1 1Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, People’s Republic of China; 2Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiaqin Xu; Bo Shen, Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, People’s Republic of China, Tel +86-13968607148 ; +86 13586121278, Email xujq@enzemed.com; shenb@enzemed.comPurpose: Information about dynamic changes occurring in the parameters and morphology of erythrocytes and platelets during the coronavirus disease 2019 (COVID-19) infection and convalescence is scarce. To explore potential associations between dynamic erythrocyte and platelet parameters, morphological changes, and the course or severity of the disease is essential.Patients and Methods: From January 17th, 2020, to February 20th, 2022, we followed up on 35 patients with non-severe and 11 patients with severe COVID-19 following their discharge. We collected clinical features, dynamic complete blood count (CBC), and peripheral blood smears (PBS) and analyzed parameter and morphological changes of erythrocytes and platelets depending on the course or severity of the disease. The course of the disease included four periods, namely onset (T1), discharge (T2), 1-year follow-up (T3), and 2-year follow-up (T4).Results: Red blood cell (RBC) counts and hemoglobin were the lowest in T2, followed by T1, and lower in T1 and T2 than in T3 and T4. Inversely, the red blood cell distribution width (RDW) was the highest in T2, followed by T1, and higher than in T3 and T4. Compared to non-severe patients, the platelet of severe patients was lower in T1 and T2. In contrast, the mean platelet volume (MPV) and platelet distribution width (PDW) tended to be higher in severe patients. Similarly, anisocytosis was more common in peripheral blood smears at early stages and in severe patients. Finally, large platelets were more common in severe patients.Conclusion: Anisocytosis of erythrocytes and large platelets are found in patients with severe COVID-19, these changes may help primary hospitals to identify patients with a high risk of severe COVID-19 at an early stage.Keywords: erythrocytes, blood platelets, COVID-19 |
| first_indexed | 2024-04-09T22:00:37Z |
| format | Article |
| id | doaj.art-3389a50b7d7b4921ac44e88b0f719bfa |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-09T22:00:37Z |
| publishDate | 2023-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-3389a50b7d7b4921ac44e88b0f719bfa2023-03-23T18:06:52ZengDove Medical PressInfection and Drug Resistance1178-69732023-03-01Volume 161657166882501Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort StudyShen LChen LChi HLuo LRuan JZhao XJiang YTung THZhu HZhou KShen BXu JLiping Shen,1,* Linping Chen,1,* Hongbo Chi,1 Lifei Luo,1 Jinsu Ruan,1 Xinzhuan Zhao,1 Yi Jiang,1 Tao-Hsin Tung,2 Hongguo Zhu,1 Kai Zhou,1 Bo Shen,1 Jiaqin Xu1 1Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, People’s Republic of China; 2Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiaqin Xu; Bo Shen, Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, People’s Republic of China, Tel +86-13968607148 ; +86 13586121278, Email xujq@enzemed.com; shenb@enzemed.comPurpose: Information about dynamic changes occurring in the parameters and morphology of erythrocytes and platelets during the coronavirus disease 2019 (COVID-19) infection and convalescence is scarce. To explore potential associations between dynamic erythrocyte and platelet parameters, morphological changes, and the course or severity of the disease is essential.Patients and Methods: From January 17th, 2020, to February 20th, 2022, we followed up on 35 patients with non-severe and 11 patients with severe COVID-19 following their discharge. We collected clinical features, dynamic complete blood count (CBC), and peripheral blood smears (PBS) and analyzed parameter and morphological changes of erythrocytes and platelets depending on the course or severity of the disease. The course of the disease included four periods, namely onset (T1), discharge (T2), 1-year follow-up (T3), and 2-year follow-up (T4).Results: Red blood cell (RBC) counts and hemoglobin were the lowest in T2, followed by T1, and lower in T1 and T2 than in T3 and T4. Inversely, the red blood cell distribution width (RDW) was the highest in T2, followed by T1, and higher than in T3 and T4. Compared to non-severe patients, the platelet of severe patients was lower in T1 and T2. In contrast, the mean platelet volume (MPV) and platelet distribution width (PDW) tended to be higher in severe patients. Similarly, anisocytosis was more common in peripheral blood smears at early stages and in severe patients. Finally, large platelets were more common in severe patients.Conclusion: Anisocytosis of erythrocytes and large platelets are found in patients with severe COVID-19, these changes may help primary hospitals to identify patients with a high risk of severe COVID-19 at an early stage.Keywords: erythrocytes, blood platelets, COVID-19https://www.dovepress.com/parameters-and-morphological-changes-of-erythrocytes-and-platelets-of--peer-reviewed-fulltext-article-IDRerythrocytes;blood plateletscovid-19 |
| spellingShingle | Shen L Chen L Chi H Luo L Ruan J Zhao X Jiang Y Tung TH Zhu H Zhou K Shen B Xu J Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort Study Infection and Drug Resistance erythrocytes;blood platelets covid-19 |
| title | Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort Study |
| title_full | Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort Study |
| title_fullStr | Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort Study |
| title_full_unstemmed | Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort Study |
| title_short | Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort Study |
| title_sort | parameters and morphological changes of erythrocytes and platelets of covid 19 subjects a longitudinal cohort study |
| topic | erythrocytes;blood platelets covid-19 |
| url | https://www.dovepress.com/parameters-and-morphological-changes-of-erythrocytes-and-platelets-of--peer-reviewed-fulltext-article-IDR |
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