Histopathologic effects of formaldehyde exposure on rat kidney
AbstractBackground and purpose: Formaldehyde is a chemical traditionally used for fixing the cadaver. It is vaporized during dissection and practical studying on cadaver. Studies show that this vapour can cause some clinical sympotms such as throat, eye, skin and nasal irritation.This study was desi...
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Mazandaran University of Medical Sciences
2007-01-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
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| Online Access: | http://www.mazums.ac.ir/files/onlineJournals_940514=davarian.pdf |
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| author | M.J. Golalipour H. Hashemnezhad S.A. Fazeli R. Azarhoush A. Davarian |
| author_facet | M.J. Golalipour H. Hashemnezhad S.A. Fazeli R. Azarhoush A. Davarian |
| author_sort | M.J. Golalipour |
| collection | DOAJ |
| description | AbstractBackground and purpose: Formaldehyde is a chemical traditionally used for fixing the cadaver. It is vaporized during dissection and practical studying on cadaver. Studies show that this vapour can cause some clinical sympotms such as throat, eye, skin and nasal irritation.This study was designed to determine the histopathological changes of rat kidney tissue exposed to formaldehyde for 18 weeks.Materials and Methods: This study was performed on 28, 6-7 weeks postnatal albino Wistar rats. The rats were divided into 3 case groups (E1: 4hrs/d, 4d/w; E2: 2hrs/d, 4d/w; E3: 2hrs/d, 2d/w) and one control group (C). The kidney specimens were sectioned and stained with H&E technique for histopathological study.Results: In all histopathology sections of groups E1, E2 and E3, the following similar changes were observed: Mild congestion in the glumeroles, focal congestion and vacuolar (hydropic) degeneration of tubular cells only mild non-specific congestion in renal vessels. There were no evidences of fibrotic change or inflammatory cells infiltration among interstitial tissue. Also there were no abnormalities in the staining of nucleus and cytoplasm. In Control group (C), no histopathologic changes were observed.Conclusion: The results of this study showed that formaldehyde vapour with a concentrations used in our study, can not induce histopathologic changes which could be detectable by light microscope. Also, there is no direct relationship between the duration of exposure to formaldehyde vapour and the intensity of histopathologic changes in the kidney. |
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| format | Article |
| id | doaj.art-3389f2ae66064d5eaecf465330f87c3e |
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| issn | 1735-9260 |
| language | English |
| last_indexed | 2024-12-21T21:38:13Z |
| publishDate | 2007-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-3389f2ae66064d5eaecf465330f87c3e2022-12-21T18:49:26ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92602007-01-011656101107Histopathologic effects of formaldehyde exposure on rat kidneyM.J. GolalipourH. HashemnezhadS.A. FazeliR. AzarhoushA. DavarianAbstractBackground and purpose: Formaldehyde is a chemical traditionally used for fixing the cadaver. It is vaporized during dissection and practical studying on cadaver. Studies show that this vapour can cause some clinical sympotms such as throat, eye, skin and nasal irritation.This study was designed to determine the histopathological changes of rat kidney tissue exposed to formaldehyde for 18 weeks.Materials and Methods: This study was performed on 28, 6-7 weeks postnatal albino Wistar rats. The rats were divided into 3 case groups (E1: 4hrs/d, 4d/w; E2: 2hrs/d, 4d/w; E3: 2hrs/d, 2d/w) and one control group (C). The kidney specimens were sectioned and stained with H&E technique for histopathological study.Results: In all histopathology sections of groups E1, E2 and E3, the following similar changes were observed: Mild congestion in the glumeroles, focal congestion and vacuolar (hydropic) degeneration of tubular cells only mild non-specific congestion in renal vessels. There were no evidences of fibrotic change or inflammatory cells infiltration among interstitial tissue. Also there were no abnormalities in the staining of nucleus and cytoplasm. In Control group (C), no histopathologic changes were observed.Conclusion: The results of this study showed that formaldehyde vapour with a concentrations used in our study, can not induce histopathologic changes which could be detectable by light microscope. Also, there is no direct relationship between the duration of exposure to formaldehyde vapour and the intensity of histopathologic changes in the kidney.http://www.mazums.ac.ir/files/onlineJournals_940514=davarian.pdfFormaldehyde exposureHistopathologic changeskidneyRat |
| spellingShingle | M.J. Golalipour H. Hashemnezhad S.A. Fazeli R. Azarhoush A. Davarian Histopathologic effects of formaldehyde exposure on rat kidney Journal of Mazandaran University of Medical Sciences Formaldehyde exposure Histopathologic changes kidney Rat |
| title | Histopathologic effects of formaldehyde exposure on rat kidney |
| title_full | Histopathologic effects of formaldehyde exposure on rat kidney |
| title_fullStr | Histopathologic effects of formaldehyde exposure on rat kidney |
| title_full_unstemmed | Histopathologic effects of formaldehyde exposure on rat kidney |
| title_short | Histopathologic effects of formaldehyde exposure on rat kidney |
| title_sort | histopathologic effects of formaldehyde exposure on rat kidney |
| topic | Formaldehyde exposure Histopathologic changes kidney Rat |
| url | http://www.mazums.ac.ir/files/onlineJournals_940514=davarian.pdf |
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