Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort Study
Background. Malformations in epidermal barrier in children with atopic dermatitis (AD) can cause transcutaneous sensitization with further development of allergic diseases that can worsen the AD course and significantly reduces patients’ quality of life.Objective. The aim of the study was to determi...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2020-12-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/2519 |
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| author | Nikolay N. Murashkin Svetlana G. Makarova Stepan G. Grigorev Dmitri V. Fedorov Roman A. Ivanov Eduard T. Ambarchian Roman V. Epishev Alexander I. Materikin Leonid A. Opryatin Alena A. Savelova |
| author_facet | Nikolay N. Murashkin Svetlana G. Makarova Stepan G. Grigorev Dmitri V. Fedorov Roman A. Ivanov Eduard T. Ambarchian Roman V. Epishev Alexander I. Materikin Leonid A. Opryatin Alena A. Savelova |
| author_sort | Nikolay N. Murashkin |
| collection | DOAJ |
| description | Background. Malformations in epidermal barrier in children with atopic dermatitis (AD) can cause transcutaneous sensitization with further development of allergic diseases that can worsen the AD course and significantly reduces patients’ quality of life.Objective. The aim of the study was to determine the effect of topical treatment and maintenance therapy with pimecrolimus 1% cream (PIM) and topical glucocorticosteroids (tGCS) in infants with AD on reducing the risk of developing transcutaneous sensitization (due to the levels of specific IgE to the cow milk protein over time) and on reducing the disease severity (by the EASI scale).Methods. The study included children aged from 1 to 4 months with early manifestations of moderate and severe AD. The severity of AD was estimated via the EASI scale at start of observation, then at 6, 9 and 12 months of life. The class and level of specific IgE to cow milk proteins (CMP) were determined by the ImmunoCAP method at the point of enrolment and at the ages of 6 and 12 months. Statistical analysis of studied indicators dynamics and their comparison in research groups was carried out using multifactorial dispersion analysis.Results. The study included 36 patients. All patients have received standard tGCS therapy in combination with emollients (wet wrap) for 10 days. The maintenance therapy was prescribed in postacute period. It included topical calcineurin inhibitor PIM 2 times/day for 3 months, then double application (morning/evening) 3 times/week up to the age of 1 year old (group 1). Other group had maintenance therapy — tGCS2 times/week for 3 months, and then at AD aggravation (group 2). Group 1 has shown lower level of sensitization to CMP at the age of 6 and 12 months and more significant decrease in AD severity according to EASI scale compared to group 2.Conclusion. The treatment with PIM is effective in therapy of AD and prevention of transcutaneous sensitization in infants. |
| first_indexed | 2024-03-12T03:04:56Z |
| format | Article |
| id | doaj.art-338b358bf0e647caacaf2e4da4d18e99 |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T03:04:56Z |
| publishDate | 2020-12-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-338b358bf0e647caacaf2e4da4d18e992023-09-03T14:32:56Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352020-12-0119653854410.15690/vsp.v19i6.21521927Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort StudyNikolay N. Murashkin0Svetlana G. Makarova1Stepan G. Grigorev2Dmitri V. Fedorov3Roman A. Ivanov4Eduard T. Ambarchian5Roman V. Epishev6Alexander I. Materikin7Leonid A. Opryatin8Alena A. Savelova9Национальный медицинский исследовательский центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Центральная государственная медицинская академия Управления делами Президента РФ; НИИ педиатрии и охраны здоровья детей ЦКБ РАННациональный медицинский исследовательский центр здоровья детей; НИИ педиатрии и охраны здоровья детей ЦКБ РАНВоенно-медицинская академия им. С.М. Кирова; Детский научно-клинический центр инфекционных болезней ФМБАНациональный медицинский исследовательский центр здоровья детейНациональный медицинский исследовательский центр здоровья детейНациональный медицинский исследовательский центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); НИИ педиатрии и охраны здоровья детей ЦКБ РАННациональный медицинский исследовательский центр здоровья детейНациональный медицинский исследовательский центр здоровья детейНациональный медицинский исследовательский центр здоровья детейЦентральная государственная медицинская академия Управления делами Президента РФBackground. Malformations in epidermal barrier in children with atopic dermatitis (AD) can cause transcutaneous sensitization with further development of allergic diseases that can worsen the AD course and significantly reduces patients’ quality of life.Objective. The aim of the study was to determine the effect of topical treatment and maintenance therapy with pimecrolimus 1% cream (PIM) and topical glucocorticosteroids (tGCS) in infants with AD on reducing the risk of developing transcutaneous sensitization (due to the levels of specific IgE to the cow milk protein over time) and on reducing the disease severity (by the EASI scale).Methods. The study included children aged from 1 to 4 months with early manifestations of moderate and severe AD. The severity of AD was estimated via the EASI scale at start of observation, then at 6, 9 and 12 months of life. The class and level of specific IgE to cow milk proteins (CMP) were determined by the ImmunoCAP method at the point of enrolment and at the ages of 6 and 12 months. Statistical analysis of studied indicators dynamics and their comparison in research groups was carried out using multifactorial dispersion analysis.Results. The study included 36 patients. All patients have received standard tGCS therapy in combination with emollients (wet wrap) for 10 days. The maintenance therapy was prescribed in postacute period. It included topical calcineurin inhibitor PIM 2 times/day for 3 months, then double application (morning/evening) 3 times/week up to the age of 1 year old (group 1). Other group had maintenance therapy — tGCS2 times/week for 3 months, and then at AD aggravation (group 2). Group 1 has shown lower level of sensitization to CMP at the age of 6 and 12 months and more significant decrease in AD severity according to EASI scale compared to group 2.Conclusion. The treatment with PIM is effective in therapy of AD and prevention of transcutaneous sensitization in infants.https://vsp.spr-journal.ru/jour/article/view/2519атопический дерматит«атопический марш»детисенсибилизациябелки коровьего молокаigeimmunocapпимекролимус |
| spellingShingle | Nikolay N. Murashkin Svetlana G. Makarova Stepan G. Grigorev Dmitri V. Fedorov Roman A. Ivanov Eduard T. Ambarchian Roman V. Epishev Alexander I. Materikin Leonid A. Opryatin Alena A. Savelova Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort Study Вопросы современной педиатрии атопический дерматит «атопический марш» дети сенсибилизация белки коровьего молока ige immunocap пимекролимус |
| title | Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort Study |
| title_full | Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort Study |
| title_fullStr | Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort Study |
| title_full_unstemmed | Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort Study |
| title_short | Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort Study |
| title_sort | prevention of transcutaneous sensitization to cow milk proteins in infants with atopic dermatitis cohort study |
| topic | атопический дерматит «атопический марш» дети сенсибилизация белки коровьего молока ige immunocap пимекролимус |
| url | https://vsp.spr-journal.ru/jour/article/view/2519 |
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