Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity

Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity

Abstract Background Galectin-3 (Gal-3), the only chimeric β-galactosides-binding lectin, consists of Gal-3N (N-terminal regulatory peptide) and Gal-3C (C-terminal carbohydrate-recognition domain). Interestingly, Gal-3C could specifically inhibit endogenous full-length Gal-3 to exhibit anti-tumor act...

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Bibliographic Details
Main Authors: Xiaoge Gao, Pin Jiang, Xiaohuan Wei, Wei Zhang, Jiwei Zheng, Shishuo Sun, Hong Yao, Xiangye Liu, Qing Zhang
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Cancer
Subjects:
Galectin-3
Angiogenesis
Carbohydrate-recognition domain
Fifth kringle of plasminogen
Hepatocellular carcinoma
Online Access:https://doi.org/10.1186/s12885-023-10608-9

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