Functional Versatility of the CDK Inhibitor p57Kip2
The cyclin/CDK inhibitor p57Kip2 belongs to the Cip/Kip family, with p21Cip1 and p27Kip1, and is the least studied member of the family. Unlike the other family members, p57Kip2 has a unique role during embryogenesis and is the only CDK inhibitor required for embryonic development. p57Kip2 is encode...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.584590/full |
| _version_ | 1818254917104566272 |
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| author | Justine Creff Arnaud Besson |
| author_facet | Justine Creff Arnaud Besson |
| author_sort | Justine Creff |
| collection | DOAJ |
| description | The cyclin/CDK inhibitor p57Kip2 belongs to the Cip/Kip family, with p21Cip1 and p27Kip1, and is the least studied member of the family. Unlike the other family members, p57Kip2 has a unique role during embryogenesis and is the only CDK inhibitor required for embryonic development. p57Kip2 is encoded by the imprinted gene CDKN1C, which is the gene most frequently silenced or mutated in the genetic disorder Beckwith–Wiedemann syndrome (BWS), characterized by multiple developmental anomalies. Although initially identified as a cell cycle inhibitor based on its homology to other Cip/Kip family proteins, multiple novel functions have been ascribed to p57Kip2 in recent years that participate in the control of various cellular processes, including apoptosis, migration and transcription. Here, we will review our current knowledge on p57Kip2 structure, regulation, and its diverse functions during development and homeostasis, as well as its potential implication in the development of various pathologies, including cancer. |
| first_indexed | 2024-12-12T17:03:35Z |
| format | Article |
| id | doaj.art-338c278154394732a727bda43258be77 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T17:03:35Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-338c278154394732a727bda43258be772022-12-22T00:18:04ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-10-01810.3389/fcell.2020.584590584590Functional Versatility of the CDK Inhibitor p57Kip2Justine CreffArnaud BessonThe cyclin/CDK inhibitor p57Kip2 belongs to the Cip/Kip family, with p21Cip1 and p27Kip1, and is the least studied member of the family. Unlike the other family members, p57Kip2 has a unique role during embryogenesis and is the only CDK inhibitor required for embryonic development. p57Kip2 is encoded by the imprinted gene CDKN1C, which is the gene most frequently silenced or mutated in the genetic disorder Beckwith–Wiedemann syndrome (BWS), characterized by multiple developmental anomalies. Although initially identified as a cell cycle inhibitor based on its homology to other Cip/Kip family proteins, multiple novel functions have been ascribed to p57Kip2 in recent years that participate in the control of various cellular processes, including apoptosis, migration and transcription. Here, we will review our current knowledge on p57Kip2 structure, regulation, and its diverse functions during development and homeostasis, as well as its potential implication in the development of various pathologies, including cancer.https://www.frontiersin.org/article/10.3389/fcell.2020.584590/fullp57Kip2CDK inhibitorcell cycledevelopmenttranscriptionstem cells |
| spellingShingle | Justine Creff Arnaud Besson Functional Versatility of the CDK Inhibitor p57Kip2 Frontiers in Cell and Developmental Biology p57Kip2 CDK inhibitor cell cycle development transcription stem cells |
| title | Functional Versatility of the CDK Inhibitor p57Kip2 |
| title_full | Functional Versatility of the CDK Inhibitor p57Kip2 |
| title_fullStr | Functional Versatility of the CDK Inhibitor p57Kip2 |
| title_full_unstemmed | Functional Versatility of the CDK Inhibitor p57Kip2 |
| title_short | Functional Versatility of the CDK Inhibitor p57Kip2 |
| title_sort | functional versatility of the cdk inhibitor p57kip2 |
| topic | p57Kip2 CDK inhibitor cell cycle development transcription stem cells |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.584590/full |
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