Entosis: From Cell Biology to Clinical Cancer Pathology
Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the bio...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/9/2481 |
| _version_ | 1797554892242419712 |
|---|---|
| author | Izabela Mlynarczuk-Bialy Ireneusz Dziuba Agnieszka Sarnecka Emilia Platos Magdalena Kowalczyk Katarzyna K. Pels Grzegorz M. Wilczynski Cezary Wojcik Lukasz P. Bialy |
| author_facet | Izabela Mlynarczuk-Bialy Ireneusz Dziuba Agnieszka Sarnecka Emilia Platos Magdalena Kowalczyk Katarzyna K. Pels Grzegorz M. Wilczynski Cezary Wojcik Lukasz P. Bialy |
| author_sort | Izabela Mlynarczuk-Bialy |
| collection | DOAJ |
| description | Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown. Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence. Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis. |
| first_indexed | 2024-03-10T16:38:32Z |
| format | Article |
| id | doaj.art-338cc8cf66a347f499f1e0e304f2b22a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T16:38:32Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-338cc8cf66a347f499f1e0e304f2b22a2023-11-20T12:12:43ZengMDPI AGCancers2072-66942020-09-01129248110.3390/cancers12092481Entosis: From Cell Biology to Clinical Cancer PathologyIzabela Mlynarczuk-Bialy0Ireneusz Dziuba1Agnieszka Sarnecka2Emilia Platos3Magdalena Kowalczyk4Katarzyna K. Pels5Grzegorz M. Wilczynski6Cezary Wojcik7Lukasz P. Bialy8Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warszawa, PolandDepartment of Pathology, West Pomeranian Hospital in Gryfice, 72-300 Gryfice, PolandHESA Association at the Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warszawa, PolandHESA Association at the Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warszawa, PolandHESA Association at the Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warszawa, PolandNencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, PolandNencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, PolandUS Cardiovascular, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USADepartment of Histology and Embryology, Medical University of Warsaw, 02-004 Warszawa, PolandEntosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown. Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence. Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis.https://www.mdpi.com/2072-6694/12/9/2481entosiscancercell internalisationcell-in-cellcell adhesioncancer prognosis |
| spellingShingle | Izabela Mlynarczuk-Bialy Ireneusz Dziuba Agnieszka Sarnecka Emilia Platos Magdalena Kowalczyk Katarzyna K. Pels Grzegorz M. Wilczynski Cezary Wojcik Lukasz P. Bialy Entosis: From Cell Biology to Clinical Cancer Pathology Cancers entosis cancer cell internalisation cell-in-cell cell adhesion cancer prognosis |
| title | Entosis: From Cell Biology to Clinical Cancer Pathology |
| title_full | Entosis: From Cell Biology to Clinical Cancer Pathology |
| title_fullStr | Entosis: From Cell Biology to Clinical Cancer Pathology |
| title_full_unstemmed | Entosis: From Cell Biology to Clinical Cancer Pathology |
| title_short | Entosis: From Cell Biology to Clinical Cancer Pathology |
| title_sort | entosis from cell biology to clinical cancer pathology |
| topic | entosis cancer cell internalisation cell-in-cell cell adhesion cancer prognosis |
| url | https://www.mdpi.com/2072-6694/12/9/2481 |
| work_keys_str_mv | AT izabelamlynarczukbialy entosisfromcellbiologytoclinicalcancerpathology AT ireneuszdziuba entosisfromcellbiologytoclinicalcancerpathology AT agnieszkasarnecka entosisfromcellbiologytoclinicalcancerpathology AT emiliaplatos entosisfromcellbiologytoclinicalcancerpathology AT magdalenakowalczyk entosisfromcellbiologytoclinicalcancerpathology AT katarzynakpels entosisfromcellbiologytoclinicalcancerpathology AT grzegorzmwilczynski entosisfromcellbiologytoclinicalcancerpathology AT cezarywojcik entosisfromcellbiologytoclinicalcancerpathology AT lukaszpbialy entosisfromcellbiologytoclinicalcancerpathology |