Taxanes induced peripheral neuropathy: mechanism of development and pharmacogenetic factors
For decades taxanes are used as a part of classical schemes for treatment of malignant tumors of various localizations including breast cancer. Peripheral neuropathy is an adverse reaction which impairs both quality of patients’ lives and treatment efficiency. To prevent or reduce the impact of peri...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IP Habib O.N.
2018-03-01
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| Series: | Современная онкология |
| Subjects: | |
| Online Access: | https://modernonco.orscience.ru/1815-1434/article/viewFile/27172/pdf |
| _version_ | 1811340844889800704 |
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| author | L V Shestakova D A Sychev I V Poddubnaya |
| author_facet | L V Shestakova D A Sychev I V Poddubnaya |
| author_sort | L V Shestakova |
| collection | DOAJ |
| description | For decades taxanes are used as a part of classical schemes for treatment of malignant tumors of various localizations including breast cancer. Peripheral neuropathy is an adverse reaction which impairs both quality of patients’ lives and treatment efficiency. To prevent or reduce the impact of peripheral neuropathy factors contributing to its development and mechanisms that are involved need to be known. This article is a review of the current status of our understanding about the mechanisms underlying the development of taxanes induced peripheral neuropathy. |
| first_indexed | 2024-04-13T18:47:58Z |
| format | Article |
| id | doaj.art-338f98fc03744ea8855948432ffc13d8 |
| institution | Directory Open Access Journal |
| issn | 1815-1434 1815-1442 |
| language | Russian |
| last_indexed | 2024-04-13T18:47:58Z |
| publishDate | 2018-03-01 |
| publisher | IP Habib O.N. |
| record_format | Article |
| series | Современная онкология |
| spelling | doaj.art-338f98fc03744ea8855948432ffc13d82022-12-22T02:34:31ZrusIP Habib O.N.Современная онкология1815-14341815-14422018-03-01201606324392Taxanes induced peripheral neuropathy: mechanism of development and pharmacogenetic factorsL V Shestakova0D A Sychev1I V Poddubnaya2Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian FederationRussian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian FederationRussian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian FederationFor decades taxanes are used as a part of classical schemes for treatment of malignant tumors of various localizations including breast cancer. Peripheral neuropathy is an adverse reaction which impairs both quality of patients’ lives and treatment efficiency. To prevent or reduce the impact of peripheral neuropathy factors contributing to its development and mechanisms that are involved need to be known. This article is a review of the current status of our understanding about the mechanisms underlying the development of taxanes induced peripheral neuropathy.https://modernonco.orscience.ru/1815-1434/article/viewFile/27172/pdfcyp2c8 rs10509681rs11572080rs1058930abcb1 rs2032582taxanesneuropathymicrotubulesmitochondrial permeability transition porepharmacogeneticscyp2c8 rs10509681rs11572080rs1058930abcb1 rs2032582 |
| spellingShingle | L V Shestakova D A Sychev I V Poddubnaya Taxanes induced peripheral neuropathy: mechanism of development and pharmacogenetic factors Современная онкология cyp2c8 rs10509681 rs11572080 rs1058930 abcb1 rs2032582 taxanes neuropathy microtubules mitochondrial permeability transition pore pharmacogenetics cyp2c8 rs10509681 rs11572080 rs1058930 abcb1 rs2032582 |
| title | Taxanes induced peripheral neuropathy: mechanism of development and pharmacogenetic factors |
| title_full | Taxanes induced peripheral neuropathy: mechanism of development and pharmacogenetic factors |
| title_fullStr | Taxanes induced peripheral neuropathy: mechanism of development and pharmacogenetic factors |
| title_full_unstemmed | Taxanes induced peripheral neuropathy: mechanism of development and pharmacogenetic factors |
| title_short | Taxanes induced peripheral neuropathy: mechanism of development and pharmacogenetic factors |
| title_sort | taxanes induced peripheral neuropathy mechanism of development and pharmacogenetic factors |
| topic | cyp2c8 rs10509681 rs11572080 rs1058930 abcb1 rs2032582 taxanes neuropathy microtubules mitochondrial permeability transition pore pharmacogenetics cyp2c8 rs10509681 rs11572080 rs1058930 abcb1 rs2032582 |
| url | https://modernonco.orscience.ru/1815-1434/article/viewFile/27172/pdf |
| work_keys_str_mv | AT lvshestakova taxanesinducedperipheralneuropathymechanismofdevelopmentandpharmacogeneticfactors AT dasychev taxanesinducedperipheralneuropathymechanismofdevelopmentandpharmacogeneticfactors AT ivpoddubnaya taxanesinducedperipheralneuropathymechanismofdevelopmentandpharmacogeneticfactors |