A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy
Context: The benefit of malaria prophylaxis in pregnancy is threatened by emergence of Plasmodium falciparum resistance to antimalarial agents for chemoprophylaxis and treatment. Aim: This study aimed to compare the effectiveness of azithromycin (AZ) with sulphadoxine-pyrimethamine (SP) for malaria...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Nigerian Postgraduate Medical Journal |
| Subjects: | |
| Online Access: | http://www.npmj.org/article.asp?issn=1117-1936;year=2016;volume=23;issue=2;spage=57;epage=61;aulast=Abdus-Salam |
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| author | Rukiyat Adeola Abdus-Salam Folasade Adenike Bello Fatai A Fehintola Ayodele O Arowojolu |
| author_facet | Rukiyat Adeola Abdus-Salam Folasade Adenike Bello Fatai A Fehintola Ayodele O Arowojolu |
| author_sort | Rukiyat Adeola Abdus-Salam |
| collection | DOAJ |
| description | Context: The benefit of malaria prophylaxis in pregnancy is threatened by emergence of Plasmodium falciparum resistance to antimalarial agents for chemoprophylaxis and treatment.
Aim: This study aimed to compare the effectiveness of azithromycin (AZ) with sulphadoxine-pyrimethamine (SP) for malaria prevention.
Settings and Design: A prospective comparative study of antenatal clinic attendees at the University College Hospital, Ibadan, Nigeria. Participants were randomised to receive SP or AZ.
Subjects and Methods: The subjects were antenatal attendees and Samples for malaria parasitaemia were collected and repeated at follow-up visits; maternal peripheral blood film, placental and cord blood samples were collected at delivery.
Statistical Analysis Used: Chi-square test and t-test in a per-protocol analysis.
Results: Of 200 participants (100 in each group), 166 (83.0%) completed the study: 86 (86.0%) of SP and 80 (80.0%) of AZ groups, respectively (P = 0.26). Four (4.7%) participants who had SP compared to five (6.2%) in AZ group developed malaria at mean gestational ages of 30.3 ± 1.56 and 33.0 ± 8.6, respectively (P = 0.56). Positive peripheral, placental and cord blood parasitaemia were found in ≤2% of the participants. Drug tolerability and foetal outcomes were comparable for both groups.
Conclusion: AZ was comparable to SP for prevention of malaria in pregnancy and may be used in patients who do not tolerate SP. |
| first_indexed | 2024-12-24T01:06:57Z |
| format | Article |
| id | doaj.art-3394478bff5a4c5bb53af99f722adc52 |
| institution | Directory Open Access Journal |
| issn | 1117-1936 2468-6875 |
| language | English |
| last_indexed | 2024-12-24T01:06:57Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Nigerian Postgraduate Medical Journal |
| spelling | doaj.art-3394478bff5a4c5bb53af99f722adc522022-12-21T17:23:09ZengWolters Kluwer Medknow PublicationsNigerian Postgraduate Medical Journal1117-19362468-68752016-01-01232576110.4103/1117-1936.186295A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancyRukiyat Adeola Abdus-SalamFolasade Adenike BelloFatai A FehintolaAyodele O ArowojoluContext: The benefit of malaria prophylaxis in pregnancy is threatened by emergence of Plasmodium falciparum resistance to antimalarial agents for chemoprophylaxis and treatment. Aim: This study aimed to compare the effectiveness of azithromycin (AZ) with sulphadoxine-pyrimethamine (SP) for malaria prevention. Settings and Design: A prospective comparative study of antenatal clinic attendees at the University College Hospital, Ibadan, Nigeria. Participants were randomised to receive SP or AZ. Subjects and Methods: The subjects were antenatal attendees and Samples for malaria parasitaemia were collected and repeated at follow-up visits; maternal peripheral blood film, placental and cord blood samples were collected at delivery. Statistical Analysis Used: Chi-square test and t-test in a per-protocol analysis. Results: Of 200 participants (100 in each group), 166 (83.0%) completed the study: 86 (86.0%) of SP and 80 (80.0%) of AZ groups, respectively (P = 0.26). Four (4.7%) participants who had SP compared to five (6.2%) in AZ group developed malaria at mean gestational ages of 30.3 ± 1.56 and 33.0 ± 8.6, respectively (P = 0.56). Positive peripheral, placental and cord blood parasitaemia were found in ≤2% of the participants. Drug tolerability and foetal outcomes were comparable for both groups. Conclusion: AZ was comparable to SP for prevention of malaria in pregnancy and may be used in patients who do not tolerate SP.http://www.npmj.org/article.asp?issn=1117-1936;year=2016;volume=23;issue=2;spage=57;epage=61;aulast=Abdus-Salamazithromycinintermittent preventive treatment for malaria in pregnancysulphadoxine-pyrimethamine |
| spellingShingle | Rukiyat Adeola Abdus-Salam Folasade Adenike Bello Fatai A Fehintola Ayodele O Arowojolu A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy Nigerian Postgraduate Medical Journal azithromycin intermittent preventive treatment for malaria in pregnancy sulphadoxine-pyrimethamine |
| title | A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy |
| title_full | A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy |
| title_fullStr | A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy |
| title_full_unstemmed | A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy |
| title_short | A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy |
| title_sort | comparative study of azithromycin and sulphadoxine pyrimethamine as prophylaxis against malaria in pregnancy |
| topic | azithromycin intermittent preventive treatment for malaria in pregnancy sulphadoxine-pyrimethamine |
| url | http://www.npmj.org/article.asp?issn=1117-1936;year=2016;volume=23;issue=2;spage=57;epage=61;aulast=Abdus-Salam |
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